Haktan Övül Bozkir,Annette Brandt,Katja Csarmann et al.
Haktan Övül Bozkir et al.
Tumor necrosis factor α (TNFα) regulates inflammation in metabolic diseases and probably aging-associated inflammation. Here, TNFα´s role in aging-related liver inflammation and fibrosis and underlying mechanisms was assessed in mice. I...
Frailty-related plasma metabolomic signatures predict long-term mortality risk and implicate systemic aging pathways: evidence from a prospective cohort study [0.03%]
与衰弱相关的血浆代谢组标志物可预测长期死亡风险并提示系统性衰老通路：前瞻性队列研究证据
Xiru Zhang,Xin Feng,Wenchao Liu et al.
Xiru Zhang et al.
Frailty is a common geriatric syndrome associated with increased mortality, yet its underlying biological mechanisms and potential value for early risk stratification remain inadequately understood. In this large prospective cohort of more ...
Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster [0.03%]
Resolution素延长果蝇寿命但会影响其运动能力和耐热性
Vaibhav Tiwary,Nares Trakooljul,Shahaf Peleg
Vaibhav Tiwary
Pharmacological modulation of monoaminergic signaling, a process targeted by many therapeutic and recreational drugs via receptors, transporters, degradation enzymes, or reuptake mechanisms, is emerging as a promising aging intervention and...
Astaxanthin improves myogenicity of aged skeletal muscle progenitor cells in a sexually dimorphic manner [0.03%]
虾青素以性别二态性的方式改善老化骨骼肌前体细胞的肌源性分化能力
Zachary Clemens,Jagruti Kosaraju,Lauren Weaver et al.
Zachary Clemens et al.
Age-related declines in skeletal muscle health are a major contributor to reduced mobility and development of sarcopenia in the elderly, yet effective interventions to prevent or reverse these declines are not fully optimized. Nutritional s...
Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women [0.03%]
结合绝经过渡期时间和血浆代谢组学可改善老年女性心血管风险分层
Qi Wang,Bo Xie,Chunying Fu et al.
Qi Wang et al.
Menopause-related metabolic remodeling may contribute to the excess cardiovascular disease (CVD) burden in aging women, yet the longitudinal metabolic correlates of time since menopause (TSM) and their prognostic value are unclear. In this ...
Stimulus-driven cerebrospinal fluid dynamics is impaired in glaucoma patients [0.03%]
原发性开角型青光眼患者脑脊液动力学异常
Ji Won Bang,Carlos Parra,Kevin Yu et al.
Ji Won Bang et al.
Cerebrospinal fluid (CSF), partly driven by sensory stimulation, is crucial for maintaining homeostasis and clearing metabolic waste. Whether such stimulus-driven CSF flow is disrupted in age-related neurodegenerative diseases of the visual...
Crosstalk between TGF-β and Wnt/β-catenin signaling drives fibrogenic and stem-like phenotypes in senescent MDA-MB-231 breast cancer cells [0.03%]
TGF-β与Wnt/β-catenin信号通路的串扰驱动衰老MDA-MB-231乳腺癌细胞的纤维化和干细胞样表型
Mona El Samarji,Elissa Alam,Mariam Dakramanji et al.
Mona El Samarji et al.
Genotoxic drugs used to treat cancer can trigger senescence, which contributes to chemotherapy resistance and tumor heterogeneity. However, the resulting cellular and molecular alterations following senescence remain poorly characterized. I...
Taxonomic and functional signatures of smoking and periodontitis severity in the subgingival microbiome of older adults [0.03%]
老年人下龈微生物组中吸烟和牙周炎严重程度的分类学和功能特征
Jale Moradi,Ellen Berggreen,Eva Gerdts et al.
Jale Moradi et al.
Periodontitis and smoking are major contributors to oral and systemic health deterioration in aging adults. This study investigated the combined effects of smoking status and periodontitis severity on the subgingival microbiome in 1107 indi...
Reversal of proteomic aging with exercise-results from the UK biobank and a 12-week intervention study [0.03%]
运动逆转衰老的蛋白质组研究——来自英国生物样本库和为期12周的干预试验的结果
Sindre Lee-Ødegård,M Austin Argentieri,Frode Norheim et al.
Sindre Lee-Ødegård et al.
Biological aging varies between individuals and may be influenced by health behaviors. Using data from 45,438 UK Biobank participants, we found that a higher proteomic aging score (ProtAgeGap) was linked to lower physical activity and incre...
Defining the marker and developmental trajectory of myeloid-derived suppressor cells in aging by single-cell transcriptomics [0.03%]
通过单细胞转录组学定义衰老过程中髓系衍生的抑制细胞的标记和发育轨迹
Yaru Su,Ruimin Wu,Haochen Ai et al.
Yaru Su et al.
Myeloid-derived suppressor cells (MDSCs) are recognized as a key mediator of immunosuppression in aging, which induce immunosenescence and increase elderly people's susceptibility to infections, cancers, autoimmune diseases, and degenerativ...