Similar minds age alike: an MRI similarity approach for predicting age-related cognitive decline [0.03%]
相似的思想同样老去：一种用于预测与年龄相关的认知衰退的MRI相似性方法
Blanca Zufiria-Gerbolés,Jiawei Sun,Jesús Pineda et al.
Blanca Zufiria-Gerbolés et al.
As individuals age, cortical alterations in brain structure contribute to cognitive decline. However, the specific patterns of age-related changes and their impact on cognition remain poorly understood. This study assessed the effects of ag...
Pawel Kordowitzki,Kejun Ying
Pawel Kordowitzki
Precise recommendations for humans to reach more than 100 years remain elusive. A recent multiomics study revealed that extreme age and poor health are not inherently linked. Longevity stems from a multifactorial resilience that involves pr...
Probiotic Lactiplantibacillus plantarum OL3246 supports healthy aging by enhancing quality of life, reducing inflammation, and modulating gut microbiota: a pilot study [0.03%]
probiotic Lactiplantibacillus plantarum OL3246通过提高生活质量、减少炎症和调节肠道微生物群来支持健康老龄化：一项初步研究
Rafał Jastrząb,Andrzej Małecki,Elżbieta Kmiecik-Małecka et al.
Rafał Jastrząb et al.
Aging is accompanied by low-grade intestinal inflammation, shifts in gut microbiota, and impaired oxidative balance. Probiotic supplementation has been proposed to mitigate these processes, yet evidence in elderly populations remains limite...
Michael Ben Ezra,Jonas Bach Garbrecht,Nasya Rasmussen et al.
Michael Ben Ezra et al.
Little is known about tissue-specific changes that occur with aging in humans. Using the description of 33 million histological samples we extract thousands of age- and mortality-associated features from text narratives that we call The Hum...
The interface of aging and salt in driving salt-sensitive hypertension: a comparative study in aged and young rats [0.03%]
老龄与盐在盐敏感性高血压发病中的交互作用：老龄和年轻大鼠的比较研究
Li Zeng,Lei Xu,Meng Chen et al.
Li Zeng et al.
Hypertension prevalence is increasing in both aging and younger populations, with high salt intake being a key environmental driver. Whether young and aged individuals exhibit similar physiological and molecular responses to salt loading re...
Parkin deficiency impairs female fertility, oocyte development, fertilization and mitochondrial function in mice [0.03%]
Parkin缺乏损害小鼠的雌性生育力、卵母细胞发育、受精和线粒体功能
Michelle Volovsky,Adolfo Rodríguez-Eguren,Yagmur Ergun et al.
Michelle Volovsky et al.
Parkin, a mitochondrial E3 ubiquitin ligase, plays a central role in mitophagy and cellular homeostasis. Although well studied in neurobiology, its role in female reproduction remains unclear. This study investigated the role of Parkin on f...
Early-onset Palmijihwang-hwan treatment modulates phospholipid metabolism and gut microbiota for healthy aging: reducing adipose inflammation and oxidative stress [0.03%]
早期使用掌蹻子含丸干预可调脂质代谢和肠道菌群健康老龄化：减少脂肪组织的炎症和氧化应激
So Min Lee,Jung Joo Yoon,Hye Yoom Kim et al.
So Min Lee et al.
Aging is characterized by progressive physiological decline and increased vulnerability to metabolic and inflammatory disturbances. Palmijihwang-hwan (PM), a traditional East Asian herbal formula, has been used empirically for age-related c...
Behavioral and psychophysical characterization of proprioceptive impairment in healthy aging: a hyper-illusory experience of movement [0.03%]
健康老龄化中本体感觉障碍的行为和心理物理特征：运动的超错觉体验
Francesco Mirabelli,Andrea Albergoni,Laura Avanzino et al.
Francesco Mirabelli et al.
Age-related deterioration of the sensorimotor system can impair proprioception. This study aimed to characterize age-related changes in the sense of position and movement. Three experiments involved two groups of participants (29 young adul...
Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging [0.03%]
S100A7表达降低与皮肤老化期间分化、自噬和衰老相关程序的改变有关
Ge Peng,Fumihiro Hattori,Hideoki Ogawa et al.
Ge Peng et al.
Skin aging involves progressive structural and functional decline, yet the underlying molecular mechanisms remain unclear. Here, we report that the antimicrobial peptide S100A7 is markedly reduced in aged keratinocytes and that its depletio...
Lisa Morse,Sandra Weiss,Christine S Ritchie et al.
Lisa Morse et al.
Evidence suggests that cancer-related accelerated aging contributes to an earlier onset of chronic diseases; persistent symptoms; and decrements in patients' quality of life. This review presents the Multifactorial Model of Cancer-related A...