Juan-Manuel Anaya,Edward A Ruiz-Narváez,Ivan David Lozada-Martinez et al.
Juan-Manuel Anaya et al.
Biological aging and immunosenescence are central to longevity, yet their interplay in centenarians remains unclear. We conducted a cross-sectional study in 160 Colombian centenarians to examine associations between biological age (PhenoAge...
Antioxidant vitamin index and risk of age-related macular degeneration: multicenter validation and clinical translation [0.03%]
抗氧化维生素指数与年龄相关性黄斑变性的风险：多中心验证和临床转化研究
Xuehao Cui,Jingwen Hui,Zheya Han et al.
Xuehao Cui et al.
Age-related macular degeneration (AMD) is a leading cause of blindness in older adults, with oxidative stress as a central driver. We proposed the Antioxidant Vitamin Index (AVI), a composite indicator integrating vitamins A, C, and E to qu...
Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential [0.03%]
解开多胺代谢在术后谵妄中的作用：对生化机制和生物标志物潜力的见解
Nazia Saiyed,Vaibhav Pandya,Xiaobei Pan et al.
Nazia Saiyed et al.
Postoperative delirium (POD) is a common complication in older surgical patients, linked to long-term cognitive decline and progression to dementia, yet its mechanisms remain unclear. We investigated arginine-related metabolites (ARMs) in c...
Short lifespan under dietary cholesterol depletion is associated with gut dysfunction in Drosophila melanogaster females [0.03%]
饮食胆固醇耗尽引起的短寿命与果蝇的肠道功能障碍有关
Brooke Zanco,Christen K Mirth,Carla M Sgrò et al.
Brooke Zanco et al.
Dietary restriction may extend lifespan by improving late-life gut health. Because micronutrients mediate the effects of macronutrient ratios on longevity, we examined how cholesterol limitation affects gut health in female Drosophila melan...
Are levels of DHEAS indicative of subjective health - results of the population-based longitudinal CARLA study [0.03%]
DHEAS水平与主观健康状况有关系吗？- 来自人口横断面研究CARLA的研究结果
Luise Charlotte Behr,Alexander Kluttig,Andreas Simm et al.
Luise Charlotte Behr et al.
Subjective and objective markers are important in describing healthy aging, yet little is known about their relationships. This study analysed the time-dependent association of dehydroepiandrosterone sulfate (DHEAS) with subjective health. ...
Molecular insight into transcriptome profiling of aerobic exercise induced changes in aged skeletal muscle [0.03%]
有氧运动诱导的衰老骨骼肌转录组变化的分子洞察
Masroor Anwar,Priyajit Kaur,Dinesh Gupta et al.
Masroor Anwar et al.
Skeletal muscle aging causes loss of both muscle mss and strength, often leading to sarcopenia. Clinical manifestation of sarcopenia has been found to improve with exercise intervention. The molecular mechanisms in response to exercise inte...
Association between repeated antibiotic prescribing and seizure- and other neuropsychiatric disorders-related hospitalization among people living with dementia: a population-based cohort study [0.03%]
重复开具抗生素与痴呆患者癫痫和其它神经精神疾病相关住院之间的联系：基于人群的队列研究
Kailin Chen,Jack C H Lau,Xiwen Qin et al.
Kailin Chen et al.
Antibiotic use is common among people living with dementia (major neurocognitive disorder) and is associated with seizures and other neuropsychiatric disorders. This population-based cohort study aims to understand the association of repeat...
MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan [0.03%]
人体生命周期中血浆衍生外泌体的微RNA谱型分析
C Ráez-Meseguer,C Navas-Enamorado,X Capó et al.
C Ráez-Meseguer et al.
Extracellular vesicles (EVs) are key mediators of intercellular communication and may reflect physiological changes during aging. We analyzed plasma-derived EVs from a healthy aging cohort stratified by age, using size exclusion chromatogra...
Association of brain age gap with BMD and incident fractures in the UK Biobank [0.03%]
英国生物银行中大脑年龄差与骨密度和骨折关系的研究
Jiong Liu,Lishan Cai,Peixuan Li et al.
Jiong Liu et al.
The aging population experiences concurrent brain aging and deterioration of bone health. Imaging-derived brain age gap (BAG) demonstrates enhanced predictive capacity for age-related pathologies compared to chronological age. This study in...
Frailty phenotype reveals heterogeneity in aging and distinct taurine associations [0.03%]
脆弱表型揭示了衰老的异质性以及与牛磺酸的不同关联
April Kim,Rebecca Keener,Ashton Omdahl et al.
April Kim et al.
Frailty, characterized by diminished physiological reserve and increased vulnerability to stressors, is a common geriatric syndrome associated with adverse health outcomes. While recent seminal studies have reported conflicting findings reg...