Xuling Chang,Yan-Feng Zhou,Ling Wang et al.
Xuling Chang et al.
The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have ...
Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice [0.03%]
两种运动训练方案对雄性小鼠骨骼肌和肝脏基因组及代谢重塑年龄依赖性影响的比较
Michel Bernier,Ignacio Navas Enamorado,Mari Carmen Gómez-Cabrera et al.
Michel Bernier et al.
Skeletal muscle adapts to different exercise training modalities with age; however, the impact of both variables at the systemic and tissue levels is not fully understood. Here, adult and old C57BL/6 male mice were assigned to one of three ...
Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence [0.03%]
吡咯喹啉醌(PQQ)能保护早衰诱导的HEI-OC1细胞线粒体功能损伤
Ying Gao,Teru Kamogashira,Chisato Fujimoto et al.
Ying Gao et al.
The aim of this study was to investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on the H2O2-induced premature senescence model in HEI-OC1 auditory cells and to elucidate its mechanism of action in vitro. ...
Mitochondrial DNA oxidative mutations are elevated in Mexican American women potentially implicating Alzheimer's disease [0.03%]
墨西哥裔美国女性的线粒体DNA氧化突变可能与阿尔茨海默病有关
Danielle Marie Reid,Robert C Barber,Roland J Thorpe Jr et al.
Danielle Marie Reid et al.
Mexican Americans (MAs) are the fastest-growing Hispanic population segment in the US; as this population increases in age, so will the societal burden of age-related diseases such as Alzheimer's disease (AD). Mitochondrial DNA (mtDNA) dama...
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men [0.03%]
烟酰胺单核苷酸长期补充可提高健康老年男性血液中烟酰胺腺嘌呤二核苷酸水平并改变其肌肉功能
Masaki Igarashi,Yoshiko Nakagawa-Nagahama,Masaomi Miura et al.
Masaki Igarashi et al.
Preclinical studies have revealed that the elevation of nicotinamide adenine dinucleotide (NAD + ) upon the administration of nicotinamide mononucleotide (NMN), an NAD + precursor, can mitigate aging-related disorders; however, human data o...
The deleterious effects of old social partners on Drosophila lifespan and stress resistance [0.03%]
旧社会伙伴对果蝇寿命和耐受性产生的不利影响
Yu-Chiao Lin,MingYang Zhang,Sheng-Hao Wang et al.
Yu-Chiao Lin et al.
Social interactions play important roles in the modulation of behavior, physiology, and, potentially, lifespan. Although longevity has been studied extensively in different model organisms, due to the complexity of social environments, the ...
Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts [0.03%]
无痴呆老年人中腕部和髋部佩戴的加速度计预测认知功能下降（一项在两个独立观察队列中开展为期1年或5年的研究）
Chengjian Shi,Niser Babiker,Jacek K Urbanek et al.
Chengjian Shi et al.
The prevalence of major neurocognitive disorders is expected to rise over the next 3 decades as the number of adults ≥65 years old increases. Noninvasive screening capable of flagging individuals most at risk of subsequent cognitive declin...
Senolytic compounds reduce epigenetic age of blood samples in vitro [0.03%]
senolytic化合物可降低体外血液样本的表观遗传年龄
Senolytic drugs raise the expectation that they can specifically eliminate a subset of senescent cells in a given tissue. In this study, we have exemplarily analyzed if a 3-day treatment of human blood samples in vitro would reduce age-asso...