Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults [0.03%]
长期耐力锻炼与结肠黏膜细胞衰老标志物降低相关性研究
Marco Demaria,Beatrice Bertozzi,Nicola Veronese et al.
Marco Demaria et al.
Regular endurance exercise training is an effective intervention for the maintenance of metabolic health and the prevention of many age-associated chronic diseases. Several metabolic and inflammatory factors are involved in the health-promo...
Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus [0.03%]
局部NAD+变化的定量揭示了下丘脑中NAD+调节的独特特异性
Sean Johnson,Kiyoshi Yoshioka,Cynthia S Brace et al.
Sean Johnson et al.
Recently, it has become a consensus that systemic decreases in NAD+ are a critical trigger for age-associated functional decline in multiple tissues and organs. The hypothalamus, which contains several functionally distinct subregions calle...
Multiple pathways promote microtubule stabilization in senescent intestinal epithelial cells [0.03%]
衰老肠道上皮细胞中促进微管稳定的多条通路
Siwei Chu,Ossama Moujaber,Serge Lemay et al.
Siwei Chu et al.
Intestinal epithelial cells are critical for gastrointestinal homeostasis. However, their function declines during aging. The aging-related loss of organ performance is largely driven by the increase in senescent cells. To date, the hallmar...
Identification of potential blood biomarkers for early diagnosis of Alzheimer's disease through immune landscape analysis [0.03%]
通过免疫景观分析识别阿尔茨海默病早期诊断的潜在血液生物标志物
Daichi Shigemizu,Shintaro Akiyama,Risa Mitsumori et al.
Daichi Shigemizu et al.
Mild cognitive impairment (MCI) is a clinical precursor of Alzheimer's disease (AD). Recent genetic studies have reported on associations between AD risk genes and immunity. Here, we obtained samples and data from 317 AD, 432 MCI, and 107 c...
Author Correction: Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence [0.03%]
作者更正：吡咯喹啉醌（PQQ）保护HEI-OC1细胞衰老相关的线粒体功能损伤
Ying Gao,Teru Kamogashira,Chisato Fujimoto et al.
Ying Gao et al.
Published Erratum
npj aging. 2022 Oct 6;8(1):14. DOI:10.1038/s41514-022-00095-w 2022
Why do older adults stand-up differently to young adults?: investigation of compensatory movement strategies in sit-to-walk [0.03%]
老年人与年轻人站立方式不同吗？——坐到行走过程中代偿运动策略的研究
Eline van der Kruk,Paul Strutton,Louis J Koizia et al.
Eline van der Kruk et al.
Functional motor redundancy enables humans to move with distinct muscle activation patterns while achieving a similar outcome. Since humans select similar strategies, there seems to be an optimal control. However, older adults move differen...
Integrated cognitive and physical fitness training enhances attention abilities in older adults [0.03%]
认知与体力综合锻炼提升老年人的注意力能力
Joaquin A Anguera,Joshua J Volponi,Alexander J Simon et al.
Joaquin A Anguera et al.
Preserving attention abilities is of great concern to older adults who are motivated to maintain their quality of life. Both cognitive and physical fitness interventions have been utilized in intervention studies to assess maintenance and e...
Paracrine-mediated rejuvenation of aged mesenchymal stem cells is associated with downregulation of the autophagy-lysosomal pathway [0.03%]
旁分泌介导的衰老间充质干细胞年轻化与自噬溶酶体通路下调有关
George Hung,Tamara Ashvetiya,Aleksandra Leszczynska et al.
George Hung et al.
Age-related differences in stem-cell potency contribute to variable outcomes in clinical stem cell trials. To help understand the effect of age on stem cell potency, bone marrow-derived mesenchymal stem cells (MSCs) were isolated from young...
Age-dependent effects of blue light exposure on lifespan, neurodegeneration, and mitochondria physiology in Drosophila melanogaster [0.03%]
不同年龄的果蝇对蓝光照射引起的寿命、神经退行性疾病及线粒体生理影响的依赖性研究
Yujuan Song,Jun Yang,Alexander D Law et al.
Yujuan Song et al.
Blue light is a predominant component of light emitting devices (LEDs), which are increasingly present in our environment. There is already accumulating evidence that blue light exposure causes damage to retinal cells in vitro and in vivo; ...
Age-dependent cognitive impairment, hydrocephalus and leukocyte infiltration in transgenic mice with endothelial expression of human EPHX2 [0.03%]
人EPHX2内皮表达转基因小鼠年龄依赖性认知障碍、脑积水和白细胞浸润
Catherine M Davis,Wenri H Zhang,Thierno M Bah et al.
Catherine M Davis et al.
Soluble epoxide hydrolase (sEH) is upregulated in microvascular endothelium of human brain with vascular cognitive impairment (VCI). Transgenic endothelial expression of human sEH in mice (Tie2hsEH) induces endothelial dysfunction (ED), a p...