Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration [0.03%]
老化通过重构下丘脑室旁核转录组来改变脱水反应
Ghadir Elsamad,André Souza Mecawi,Audrys G Pauža et al.
Ghadir Elsamad et al.
Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly mo...
Xia Wang,Maria N Starodubtseva,Carolyn M Kapron et al.
Xia Wang et al.
Vascular aging is a major contributing factor to cardiovascular disease. The aged blood vessels, characterized by vascular wall thickening and stiffening, are instigated by endothelial cell dysfunction induced by oxidative stress and inflam...
Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models [0.03%]
一种senotherapeutic肽疗法可降低人体皮肤模型的生物年龄和衰老负担
Alessandra Zonari,Lear E Brace,Kallie Al-Katib et al.
Alessandra Zonari et al.
Cellular senescence is known to play a role in age-related skin function deterioration which potentially influences longevity. Here, a two-step phenotypic screening was performed to identify senotherapeutic peptides, leading to the identifi...
Gut microbiota and circadian rhythm in Alzheimer's disease pathophysiology: a review and hypothesis on their association [0.03%]
阿尔茨海默病病理生理中肠道菌群和生物钟节律的关联性研究与假设综述
Mohammad Rafi Khezri,Morteza Ghasemnejad-Berenji
Mohammad Rafi Khezri
Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia worldwide. Different pathologic changes have been introduced to be involved in its progression. Although amyloid-β (Aβ) deposition and...
Recent insights into the crosstalk between senescent cells and CD8 T lymphocytes [0.03%]
近期衰老细胞与CD8 T淋巴细胞串话的最新见解
Ines Marin,Manuel Serrano,Federico Pietrocola
Ines Marin
Recent reports in oncological and non-oncological experimental setups provide strong evidence that senescent cells are under the surveillance of CD8 T cell-mediated adaptive immunity. These new data also shed light on the mechanisms that se...
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans [0.03%]
烟酸单核苷酸口服补充剂可改变大鼠和小鼠而非人类的肠道微生物组成
A Augusto Peluso,Agnete T Lundgaard,Parizad Babaei et al.
A Augusto Peluso et al.
The gut microbiota impacts systemic levels of multiple metabolites including NAD+ precursors through diverse pathways. Nicotinamide riboside (NR) is an NAD+ precursor capable of regulating mammalian cellular metabolism. Some bacterial famil...
Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum [0.03%]
衰老通过减少钙网蛋白表达改变小鼠背外侧纹状体星形胶质细胞终足的自发性钙信号
Sara M Zarate,Taylor E Huntington,Pooneh Bagher et al.
Sara M Zarate et al.
Aging-related impairment of the blood brain barrier (BBB) and neurovascular unit (NVU) increases the risk for neurodegeneration. Among various cells that participate in BBB and NVU function, calcium signals in astrocytic endfeet are crucial...
Author Correction: How does hormesis impact biology, toxicology, and medicine? [0.03%]
作者更正：激素作用如何影响生物学、毒理学和医学？
Edward J Calabrese,Mark P Mattson
Edward J Calabrese
Published Erratum
npj aging. 2023 Mar 31;9(1):6. DOI:10.1038/s41514-023-00101-9 2023
Factors for optimizing intervention programs for cognition in older adults: the value of exergames [0.03%]
改善老年人认知的介入计划的因素——体感游戏的价值评估
Alexandra Perrot,Pauline Maillot
Alexandra Perrot
This review presents factors that could optimize the effectiveness of an intervention program on cognitive health in older adults. Combined, multi-dimensional and interactive programs appear to be relevant. On one hand, for the characterist...
Increased activity of lacrimal gland mast cells are associated with corneal epitheliopathy in aged mice [0.03%]
衰老小鼠泪腺肥大细胞活性增加与角膜上皮病变有关
Elsayed Elbasiony,WonKyung J Cho,Aastha Singh et al.
Elsayed Elbasiony et al.
The lacrimal gland undergoes significant structural and functional deterioration with aging. Marked with increased inflammation and fibrosis, the aged lacrimal gland is unable to perform its protective function. As a result, the ocular surf...