Developing cognitive workload and performance evaluation models using functional brain network analysis [0.03%]
基于脑功能网络分析的认知负荷和绩效评价模型研究
Saeed Shadpour,Ambreen Shafqat,Serkan Toy et al.
Saeed Shadpour et al.
Cognition, defined as the ability to learn, remember, sustain attention, make decisions, and solve problems, is essential in daily activities and in learning new skills. The purpose of this study was to develop cognitive workload and perfor...
Accelerated epigenetic aging and decreased natural killer cells based on DNA methylation in patients with untreated major depressive disorder [0.03%]
未治疗的重大抑郁症患者基于DNA甲基化的表观遗传衰老加速和自然杀伤细胞减少
Ryota Shindo,Takaki Tanifuji,Satoshi Okazaki et al.
Ryota Shindo et al.
Major depressive disorder (MDD) is known to cause significant disability. Genome-wide DNA methylation (DNAm) profiles can be used to estimate biological aging and as epigenetic clocks. However, information on epigenetic clocks reported in M...
Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults [0.03%]
血浆sclerostin水平升高与认知正常老年人高脑内淀粉样蛋白负荷有关
Jun Yuan,Steve Pedrini,Rohith Thota et al.
Jun Yuan et al.
Osteoporosis and Alzheimer's disease (AD) mainly affect older individuals, and the possibility of an underlying link contributing to their shared epidemiological features has rarely been investigated. In the current study, we investigated t...
Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach [0.03%]
系统生物学方法揭示重症新冠肺炎患者的抗磷脂抗体和血小板相关自身抗体水平随年龄增加而升高
Dennyson Leandro M Fonseca,Igor Salerno Filgueiras,Alexandre H C Marques et al.
Dennyson Leandro M Fonseca et al.
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, and chronic respiratory disease). However, d...
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca2+ overload in Caenorhabditis elegans [0.03%]
线粒体酸5号可通过减轻与秀丽隐杆线虫中线粒体钙超载相关的年龄依赖性神经肌肉功能障碍来改善机体健康状态
XinTong Wu,Miku Seida,Takaaki Abe et al.
XinTong Wu et al.
Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson's disease models. Here, we found that 10 μM MA-5 attenuates the age-related d...
Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer's disease brain proteomic signature [0.03%]
无偏差的蛋白质组学和多变量正则回归技术鉴定了SMOC1、NOG、APCS和NTN1作为阿尔茨海默病大脑蛋白质组特征标志物
Jackson A Roberts,Vijay R Varma,Julián Candia et al.
Jackson A Roberts et al.
Advancements in omics methodologies have generated a wealth of high-dimensional Alzheimer's disease (AD) datasets, creating significant opportunities and challenges for data interpretation. In this study, we utilized multivariable regulariz...
Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity [0.03%]
模拟微重力下老化组织生态位对树突状细胞免疫潜能的影响
Mei ElGindi,Jiranuwat Sapudom,Anna Garcia Sabate et al.
Mei ElGindi et al.
Microgravity accelerates the aging of various physiological systems, and it is well acknowledged that aged individuals and astronauts both have increased susceptibility to infections and poor response to vaccination. Immunologically, dendri...
Biomarkers selection and mathematical modeling in biological age estimation [0.03%]
生物学年龄估算中的生物标志物选择和数学建模方法研究
Solim Essomandan Clémence Bafei,Chong Shen
Solim Essomandan Clémence Bafei
Biological age (BA) is important for clinical monitoring and preventing aging-related disorders and disabilities. Clinical and/or cellular biomarkers are measured and integrated in years using mathematical models to display an individual's ...
Author Correction: Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction [0.03%]
作者更正：衰老的心肌细胞在心肌梗死后导致心脏功能障碍
Rachael E Redgrave,Emily Dookun,Laura K Booth et al.
Rachael E Redgrave et al.
Published Erratum
npj aging. 2023 Jun 23;9(1):16. DOI:10.1038/s41514-023-00115-3 2023
Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction [0.03%]
衰老的心肌细胞在心肌梗死后导致心脏功能障碍的作用
Rachael E Redgrave,Emily Dookun,Laura K Booth et al.
Rachael E Redgrave et al.
Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion is now standard therapy, pathological remodelling leading to heart failure remains a clinical problem. Cellular senescence has been shown to contribute t...