An ensemble learning model for continuous cognition assessment based on resting-state EEG [0.03%]
基于静息态EEG的连续认知评估集成学习模型
Jingnan Sun,Yike Sun,Anruo Shen et al.
Jingnan Sun et al.
One critical manifestation of neurological deterioration is the sign of cognitive decline. Causes of cognitive decline include but are not limited to: aging, cerebrovascular disease, Alzheimer's disease, and trauma. Currently, the primary t...
Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS) [0.03%]
双同位素介导液相色谱串联质谱(dimeLC-MS/MS)绝对定量生物样本中的尼克酰单核苷酸
Junya Unno,Kathryn F Mills,Tairo Ogura et al.
Junya Unno et al.
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite for fundamental biological phenomena, including aging. Nicotinamide mononucleotide (NMN) is a key NAD+ intermediate that has been extensively tested as an effective NAD+-bo...
The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer's disease in APOE [Formula: see text]4-negative Japanese adults [0.03%]
HLA-DRB1*09:01-DQB1*03:03单倍型与APOE [公式:请参见文本]4阴性日本成年人晚发性阿尔茨海默病的风险相关
Daichi Shigemizu,Koya Fukunaga,Akiko Yamakawa et al.
Daichi Shigemizu et al.
Late-onset Alzheimer's disease (LOAD) is the most common cause of dementia among those older than 65 years. The onset of LOAD is influenced by neuroinflammation. The human leukocyte antigen (HLA) system is involved in regulating inflammator...
Mendelian randomization study supports the causal effects of air pollution on longevity via multiple age-related diseases [0.03%]
孟德尔随机化研究支持空气污染通过多种年龄相关疾病影响寿命的因果效应
Shizheng Qiu,Yang Hu,Guiyou Liu
Shizheng Qiu
Growing evidence suggests that exposure to fine particulate matter (PM2.5) may reduce life expectancy; however, the causal pathways of PM2.5 exposure affecting life expectancy remain unknown. Here, we assess the causal effects of geneticall...
SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model [0.03%]
SAM、SAH和秀丽隐杆线虫的寿命：AHCY部分缺乏模型的新见解
Pankaj Thapa,Katarzyna Olek,Agata Kowalska et al.
Pankaj Thapa et al.
Supplementation with S-adenosylhomocysteine (SAH) extends the lifespan of model organisms. To explore the impact of SAH on aging, we generated a Caenorhabditis elegans model by introducing the S-adenosylhomocysteine hydrolase (AHCY-1) varia...
Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma [0.03%]
原发性开角型青光眼和正常眼压性青光眼中房水中的谷胱甘肽水平
Kota Sato,Daisuke Saigusa,Taiki Kokubun et al.
Kota Sato et al.
Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to understand physiological and pathological conditions in the eye. In the current study, we u...
Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance [0.03%]
低认知表现的非裔美国人中较低的循环adropin水平
Geetika Aggarwal,Theodore K Malmstrom,John E Morley et al.
Geetika Aggarwal et al.
We recently reported accelerated cognitive decline in Europeans aged > 70 years with low circulating adropin levels. Adropin is a small, secreted peptide that is highly expressed in the human nervous system. Expression profiling indicate re...
Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation [0.03%]
中年C57BL/6小鼠的p53自发激活可缓解低剂量电离辐射诱导的寿命延长的适应性反应
Masaoki Kohzaki,Keiji Suzuki,Akira Ootsuyama et al.
Masaoki Kohzaki et al.
Understanding the biological effects of low-dose (
How does apathy impact exploration-exploitation decision-making in older patients with neurocognitive disorders? [0.03%]
冷漠如何影响神经认知障碍老年患者的探索与开采决策？
Lyne Daumas,Raphaël Zory,Isabel Junquera-Badilla et al.
Lyne Daumas et al.
Apathy is a pervasive clinical syndrome in neurocognitive disorders, characterized by a quantitative reduction in goal-directed behaviors. The brain structures involved in the physiopathology of apathy have also been connected to the brain ...
Assessing cognitive decline in the aging brain: lessons from rodent and human studies [0.03%]
衰老大脑的认知衰退评估：来自啮齿动物和人类研究的启示
D V C Brito,F Esteves,A T Rajado et al.
D V C Brito et al.
As life expectancy continues to increase worldwide, age-related dysfunction will largely impact our societies in the future. Aging is well established to promote the deterioration of cognitive function and is the primary risk factor for the...