Cost of care for Alzheimer's disease and related dementias in the United States: 2016 to 2060 [0.03%]
美国阿尔茨海默病及相关痴呆护理费用：2016年至2060年
Arindam Nandi,Nathaniel Counts,Janina Bröker et al.
Arindam Nandi et al.
Medical and long-term care for Alzheimer's disease and related dementias (ADRDs) can impose a large economic burden on individuals and societies. We estimated the per capita cost of ADRDs care in the in the United States in 2016 and project...
Mitochondrial function in peripheral blood cells across the human lifespan [0.03%]
人一生中外周血细胞的线粒体功能变化
Johannes K Ehinger,Emil Westerlund,Eleonor Åsander Frostner et al.
Johannes K Ehinger et al.
Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mi...
Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment [0.03%]
senolytics：从药理抑制剂到免疫疗法，患者治疗的未来前景广阔
V Lelarge,R Capelle,F Oger et al.
V Lelarge et al.
The involvement of cellular senescence in the initiation and propagation of diseases is clearly characterized, making the elimination of senescent cells essential to treat age-related diseases. The development of senolytic drugs demonstrate...
Marco Quarta,Marco Demaria
Marco Quarta
John D Henderson,Sophia N Z Quigley,Shruti S Chachra et al.
John D Henderson et al.
Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to i...
A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging [0.03%]
多柔比星诱导的心脏毒性及老化的病理生理机制综述
Annet Nicole Linders,Itamar Braga Dias,Teresa López Fernández et al.
Annet Nicole Linders et al.
The population of cancer survivors is rapidly increasing due to improving healthcare. However, cancer therapies often have long-term side effects. One example is cancer therapy-related cardiac dysfunction (CTRCD) caused by doxorubicin: up t...
Attitudes and barriers towards deprescribing in older patients experiencing polypharmacy: a narrative review [0.03%]
老年多药用药患者减少药物的态度和障碍：叙事综述
Michael Robinson,Sophie Mokrzecki,Andrew J Mallett
Michael Robinson
Polypharmacy, commonly defined as ≥5 medications, is a rising public health concern due to its many risks of harm. One commonly recommended strategy to address polypharmacy is medication reviews, with subsequent deprescription of inappropr...
Author Correction: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma [0.03%]
作者更正：原发性开角型青光眼和正常眼压性青光眼患者房水中还原型谷胱甘肽水平降低
Kota Sato,Daisuke Saigusa,Taiki Kokubun et al.
Kota Sato et al.
Published Erratum
npj aging. 2024 Jan 20;10(1):8. DOI:10.1038/s41514-024-00137-5 2024
Cholesterol biosynthetic pathway induces cellular senescence through ERRα [0.03%]
胆固醇生物合成路径通过ERRα诱导细胞衰老
Dorian V Ziegler,Joanna Czarnecka-Herok,Mathieu Vernier et al.
Dorian V Ziegler et al.
Cellular senescence is a cell program induced by various stresses that leads to a stable proliferation arrest and to a senescence-associated secretory phenotype. Accumulation of senescent cells during age-related diseases participates in th...
Machine learning prediction of hepatic steatosis using body composition parameters: A UK Biobank Study [0.03%]
使用身体成分参数预测肝脂肪变性的机器学习：英国生物银行研究
Delbert Almerick T Boncan,Yan Yu,Miaoru Zhang et al.
Delbert Almerick T Boncan et al.
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disease worldwide, yet detection has remained largely based on surrogate serum biomarkers, elastography or biopsy. In this study, we used a total of 2...