Dynamics of Wnt/β-catenin reporter activity throughout whole life in a naturally short-lived vertebrate [0.03%]
一种自然短命脊椎动物生命周期中Wnt/β-catenin报告基因活性的动态变化规律研究
Shohei Ogamino,Moeko Yamamichi,Ken Sato et al.
Shohei Ogamino et al.
Wnt/β-catenin signaling plays a major role in regulation of embryogenesis, organogenesis, and adult tissue homeostasis and regeneration. However, the roles played by Wnt/β-catenin and the spatiotemporal regulation of its activity througho...
Healthcare on the brink: navigating the challenges of an aging society in the United States [0.03%]
老龄化社会来临，美国医疗体系何去何从
Charles H Jones,Mikael Dolsten
Charles H Jones
The US healthcare system is at a crossroads. With an aging population requiring more care and a strained system facing workforce shortages, capacity issues, and fragmentation, innovative solutions and policy reforms are needed. This paper a...
Oxidative damage in the gastrocnemius predicts long-term survival in patients with peripheral artery disease [0.03%]
腓动脉疾病患者存活率预测因素研究
Panagiotis Koutakis,Hernan Hernandez,Dimitrios Miserlis et al.
Panagiotis Koutakis et al.
Patients with peripheral artery disease (PAD) have increased mortality rates and a myopathy in their affected legs which is characterized by increased oxidative damage, reduced antioxidant enzymatic activity and defective mitochondrial bioe...
Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline [0.03%]
正常老化大脑的脑萎缩将牙齿丧失和饮食变化与未来的认知衰退联系起来
Hiroyuki Nakamura,Moeko Noguchi-Shinohara,Mai Ishimiya-Jokaji et al.
Hiroyuki Nakamura et al.
Several studies have found associations between poor oral health, particularly tooth loss and cognitive decline. However, the specific brain regions affected by tooth loss and the probable causes remain unclear. We conducted a population-ba...
Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression [0.03%]
阿尔茨海默病患者大脑中固有免疫向适应性免疫应答的转换与Tau蛋白病变进展相关
Marcos R Costa
Marcos R Costa
Neuroinflammation is a key feature of Alzheimer's disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD provides evidence supporting a switch from an innate to an ad...
Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans [0.03%]
FOXO3长寿基因型对冲绳人细胞老化机制的新保护作用
Trevor H Torigoe,D Craig Willcox,Michio Shimabukuro et al.
Trevor H Torigoe et al.
The genetic association of FOXO3 genotypes with human longevity is well established, although the mechanism is not fully understood. We now report on the relationship of the FOXO3 longevity variant rs2802292 with telomere length, telomerase...
Effects of ageing and frailty on circulating monocyte and dendritic cell subsets [0.03%]
衰老和虚弱对循环单核细胞和树突状细胞亚群的影响
Rosanne D Reitsema,Ashok K Kumawat,Bernd-Cornèl Hesselink et al.
Rosanne D Reitsema et al.
Ageing is associated with dysregulated immune responses, resulting in impaired resilience against infections and low-grade inflammation known as inflammageing. Frailty is a measurable condition in older adults characterized by decreased hea...
Your move: A precision medicine framework for physical activity in aging [0.03%]
你的选择：用于衰老人群的体力活动精准医疗框架
Adrián Noriega de la Colina,Timothy P Morris,Arthur F Kramer et al.
Adrián Noriega de la Colina et al.
The accelerating digital health landscape, coupled with the proliferation of wearable devices and advanced neuroimaging, offers an unprecedented avenue to develop precision interventions for enhancing physical activity in aging. This approa...
Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases [0.03%]
年龄与疾病相互作用加速弹性蛋白降解：这是老龄化相关疾病的共同特征
Naomi Shek,Anna-Maria Choy,Chim C Lang et al.
Naomi Shek et al.
Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in agin...
Author Correction: Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models [0.03%]
作者更正：senotherapeutic肽治疗可减少人类皮肤模型的生物学年龄和衰老负担
Alessandra Zonari,Lear E Brace,Kallie Al-Katib et al.
Alessandra Zonari et al.
Published Erratum
npj aging. 2024 Feb 15;10(1):14. DOI:10.1038/s41514-024-00140-w 2024