The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis [0.03%]
髌下脂肪垫、炎症老化、膝关节健康和骨关节炎之间的关系
Magnolia G Wang,Patrick Seale,David Furman
Magnolia G Wang
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion in annual healthcare expenditures only in the United States. Obesity, aging, and joint injury are major risk factors for OA development and progre...
D Jothi,Linda Anna Michelle Kulka
D Jothi
The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem Cells) has led to a better understanding of aging and age-related diseases like Parkinson's, and Alzheimer's. The established patient-derived disease ...
Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns [0.03%]
转录组分析揭示食蟹猴生命周期中的年龄相关免疫特征
Hyeon-Mu Cho,Se-Hee Choe,Ja-Rang Lee et al.
Hyeon-Mu Cho et al.
Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings. Therefore, we investigated the transcriptomic characteristics of eight male healthy cynomo...
Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer's disease rat model as a measure of early network alterations [0.03%]
基于TgF344-AD型阿尔茨海默病大鼠默认模式样网络节点中介中心性度量的早期网络改变迹象
Saba Amiri,Monica van den Berg,Mohammad-Reza Nazem-Zadeh et al.
Saba Amiri et al.
This study investigates brain network alterations in the default mode-like network (DMLN) at early stages of disease progression in a rat model of Alzheimer's disease (AD) with application in the development of early diagnostic biomarkers o...
Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice [0.03%]
血管平滑肌细胞衰老在动脉瘤性Fibulin-4突变小鼠中的增强现象
Sanne J M Stefens,Nicole van Vliet,Arne IJpma et al.
Sanne J M Stefens et al.
Aortic aneurysms are dilatations of the aorta that can rupture when left untreated. We used the aneurysmal Fibulin-4R/R mouse model to further unravel the underlying mechanisms of aneurysm formation. RNA sequencing of 3-month-old Fibulin-4R...
Linda Ravazzano,Graziana Colaianni,Anna Tarakanova et al.
Linda Ravazzano et al.
The world population is increasingly aging, deeply affecting our society by challenging our healthcare systems and presenting an economic burden, thus turning the spotlight on aging-related diseases: exempli gratia, osteoporosis, a silent d...
Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study [0.03%]
一项多模态脑影像研究：探究营养生物标志物与健康大脑衰老的关系
Christopher E Zwilling,Jisheng Wu,Aron K Barbey
Christopher E Zwilling
The emerging field of Nutritional Cognitive Neuroscience aims to uncover specific foods and nutrients that promote healthy brain aging. Central to this effort is the discovery of nutrient profiles that can be targeted in nutritional interve...
Yantong Wan,Jinxi Liu,Yiyin Mai et al.
Yantong Wan et al.
Hormesis, an adaptive response, occurs when exposure to low doses of a stressor potentially induces a stimulatory effect, while higher doses may inhibit it. This phenomenon is widely observed across various organisms and stressors, signific...
Author Correction: Healthcare on the brink: navigating the challenges of an aging society in the United States [0.03%]
作者更正：美国医疗保健走钢丝：如何应对老龄化社会的挑战
Charles H Jones,Mikael Dolsten
Charles H Jones
Published Erratum
npj aging. 2024 May 10;10(1):25. DOI:10.1038/s41514-024-00153-5 2024
EPB41L4A-AS1 is required to maintain basal autophagy to modulates Aβ clearance [0.03%]
EPB41L4A-AS1通过维持基础自噬来调节Aβ清除
Ziqiang Wang,Ruomei Wang,Lixin Niu et al.
Ziqiang Wang et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by the deposition of β-amyloid (Aβ) plaques. Aβ is generated from the cleavage of the amyloid precursor protein by β and γ-secretases and cleared by n...