The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study [0.03%]
克洛托蛋白和沉默信息调节因子在睡眠相关心血管疾病中作用的研究进展：综述文章
Farzaneh Rostamzadeh,Siyavash Joukar,Mahboobeh Yeganeh-Hajahmadi
Farzaneh Rostamzadeh
The prevalence of sleep disorders has been reported from 1.6% to 56.0%, worldwide. Sleep deprivation causes cardiovascular diseases (CVDs) including atherosclerosis, vascular aging, hypertension, heart dysfunction, reduced heart rate variab...
Prenatal exposure to undernutrition is associated with a specific lipid profile predicting future brain aging [0.03%]
宫内营养不良暴露与特定脂质谱相关，可预测未来大脑衰老
Stuart G Snowden,Albert Koulman,Christian Gaser et al.
Stuart G Snowden et al.
Prenatal adversity affects cognitive and brain aging. Both lipid and leptin concentrations may be involved. We investigated if prenatal undernutrition is associated with a specific blood lipid profile and/or leptin concentrations, and if th...
The paradox of senescent-marker positive cancer cells: challenges and opportunities [0.03%]
衰老标志阳性癌细胞的悖论：挑战与机遇
Emily A O&#x;Sullivan,Ryan Wallis,Federica Mossa et al.
Emily A O&#x;Sullivan et al.
Senescence is an anti-tumour mechanism and hallmark of cancer. Loss or mutation of key senescence effectors, such as p16INK4A, are frequently observed in cancer. Intriguingly, some human tumours are both proliferative and senescent-marker p...
Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function [0.03%]
糖代谢与正常认知功能老年人海马体积较小的关系
Ayano Shima,Moeko Noguchi-Shinohara,Shutaro Shibata et al.
Ayano Shima et al.
We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health check...
Monitoring reaction time to digital device in the very-old to detect early cognitive decline [0.03%]
监测数字设备的反应时间以检测老年人群中的早期认知衰退
Yukari Yamada,Tadahisa Okuda,Tomoe Uchida et al.
Yukari Yamada et al.
Early detection of cognitive decline is essential for timely intervention and effective management of age-related impairments. We monitored repetitive reaction times to a simple task on senior-friendly tablet computers among 72 functionally...
Francisco Alejandro Lagunas-Rangel
Francisco Alejandro Lagunas-Rangel
Heterochronic parabiosis consists of surgically connecting the circulatory systems of a young and an old animal. This technique serves as a model to study circulating factors that accelerate aging in young organisms exposed to old blood or ...
Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation [0.03%]
珍贵的2GPT：多组学预训练变压器与条件扩散在人工多组学跨物种多组织样本生成中的结合应用
Denis Sidorenko,Stefan Pushkov,Akhmed Sakip et al.
Denis Sidorenko et al.
Synthetic data generation in omics mimics real-world biological data, providing alternatives for training and evaluation of genomic analysis tools, controlling differential expression, and exploring data architecture. We previously develope...
Shared whole environmental etiology between Alzheimer's disease and age-related macular degeneration [0.03%]
阿尔茨海默病和年龄相关性黄斑变性共有的整体环境致病因素
Siting Ye,Shuo Ma,Shunming Liu et al.
Siting Ye et al.
The comorbidity of Alzheimer's disease (AD) and age-related macular degeneration (AMD) has been established in clinical and genetic studies. There is growing interest in determining the shared environmental factors associated with both cond...
Jéssica D Hense,José V V Isola,Driele N Garcia et al.
Jéssica D Hense et al.
This review explores the relationship between ovarian aging and senescent cell accumulation, as well as the efficacy of senolytics to improve reproductive longevity. Reproductive longevity is determined by the age-associated decline in ovar...
Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention [0.03%]
通过PEPITEM干预促进小鼠老化过程中白细胞迁移能力的恢复
Sophie J Hopkin,Poppy Nathan,Laleh Pezhman et al.
Sophie J Hopkin et al.
Inflammageing leads to uncontrolled leukocyte trafficking in response to inflammatory insults. Here, we used a zymosan-induced peritonitis mouse model on inflammation to investigate the role of the PEPITEM pathway on leukocyte migration in ...