Luís M Silva,Alessandro Belli,Jacob C Koella
Luís M Silva
The redox theory of aging proposes that an oxidative imbalance, possibly amplified by infection, drives senescence. We experimentally evolved mosquitoes under early or late reproduction with or without parasite exposure, and quantified long...
Stroke in persistent chronic kidney disease condition alters innate-immunity to escalate mitochondrial dysfunction and aging [0.03%]
持续性慢性肾脏病状态下中风通过改变先天免疫功能来加重线粒体功能障碍和衰老
Aishika Datta,Karan Sehgal,Deepaneeta Sarmah et al.
Aishika Datta et al.
Stroke is one of the leading causes of mortality and disability worldwide, with ischemic stroke accounting for over 87% of all stroke cases. Chronic kidney disease (CKD) is one of the major risk factors for stroke, as CKD patients have show...
Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming [0.03%]
Senolytic疗法的新兴策略：从广谱杀伤衰老细胞到精准重编程
Weidong Zhang,Shijie Song,Yue Zhang et al.
Weidong Zhang et al.
Cellular senescence, originally described as a finite proliferative arrest in cultured somatic cells, has since been recognized as a central mechanism underlying aging and the development of age-associated disorders. The progressive accumul...
Epigenetic aging and cancer incidence in a German cohort of older adults [0.03%]
表观遗传衰老与德国老年成人癌症发病率的关系
Qiming Yin,Joshua Stevenson-Hoare,Bernd Holleczek et al.
Qiming Yin et al.
Rising life expectancy and an aging population highlight the importance of cancer control. DNA methylation (DNAm)-based biological age (BA) may provide insights into aging, carcinogenesis, and cancer prevention and care. We estimated five B...
Ryan T Morse,Kyle A Mani,Hyman B Muss et al.
Ryan T Morse et al.
The number of older adults with cancer in the United States is continuously growing, while disparities in cancer care remain significant. The aim of this current work is to describe epidemiological characteristics and trends in older adults...
Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment [0.03%]
化合物尿石素A通过早期激活线粒体自噬预防老年性认知障碍，但晚期激活无法逆转认知障碍的发展
Claudia Jara,Leslye Venegas-Zamora,Han S Park-Kang et al.
Claudia Jara et al.
The hippocampus is crucial to learning and memory, functions that decline with age due to impaired mitochondrial bioenergetics and reduced mitophagy, resulting in the accumulation of dysfunctional mitochondria and increased susceptibility t...
Hongyuan Wang,Carina C Kern,Chiminh Nguyen Hong et al.
Hongyuan Wang et al.
Interventions that extend lifespan in animal models could, in principle, decelerate the aging process as a whole. Alternatively, they could act by suppressing one or more individual late-life pathologies that contribute to mortality. Here w...
Aging and increased cancer risk: exploring the potential of LE8 score to mitigate risk [0.03%]
衰老与癌症风险增加：探讨LE8评分降低风险的潜力
Jiehui Li,Yuhan Zhang,Wenxing Zhang et al.
Jiehui Li et al.
Given global population aging and the absence of aging-reversal therapies, elucidating the aging-related cancer risk association and developing cancer prevention strategies are imperative. This population-based cohort study analyzed data fr...
Spontaneous speech enables scalable digital phenotyping of physical functional deficits in aging [0.03%]
自发性语音能够对衰老引起的生理功能缺损进行可扩展的数字化表型研究
Eloïse Da Cunha,Raphaël Zory,Frédéric Chorin et al.
Eloïse Da Cunha et al.
The rising global burden of pathological aging engenders an urgent need for accessible tools enabling early detection of physical decline, which significantly impacts quality of life and healthcare systems. We hypothesized that speech analy...
From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices [0.03%]
从手腕数据到寿命：通过可穿戴设备捕获的活动节律阐明炎症驱动的生物衰老
Jinjoo Shim,Faraz Bishehsari,Mahboobeh Mahdavinia et al.
Jinjoo Shim et al.
Systemic inflammation ("inflammaging") accelerates biological aging and drives cardiovascular, metabolic, and neurodegenerative disease. Circadian rhythms regulate the amplitude and timing of immune responses, yet their mechanistic role in ...