Aging modulates the impact of cognitive interference subtypes on dynamic connectivity across a distributed motor network [0.03%]
老化调制了认知干扰亚型对分布式运动网络动态连接的影响
Jake J Son,Yasra Arif,Hannah J Okelberry et al.
Jake J Son et al.
Research has shown age-related declines in cognitive control in the context of interference, but these studies have focused on frontoparietal networks and less is known about impacts on motor response-related dynamics in the face of distrac...
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations [0.03%]
衰老的新兴见解：从非临床模型到治疗创新的途径
Luke Mansfield,Valentina Ramponi,Kavya Gupta et al.
Luke Mansfield et al.
Senescence is a crucial hallmark of ageing and a significant contributor to the pathology of age-related disorders. As committee members of the young International Cell Senescence Association (yICSA), we aim to synthesise recent advancement...
Whole-genome sequencing to identify rare variants in East Asian patients with dementia with Lewy bodies [0.03%]
全基因组测序在东亚路易体痴呆罕见变异患者中的识别作用
Tetsuaki Kimura,Kosuke Fujita,Takashi Sakurai et al.
Tetsuaki Kimura et al.
Dementia with Lewy bodies (DLB) is the second most common form of age-related dementia, following Alzheimer's disease (AD). DLB is associated with a worse prognosis than AD and is characterized by a more rapid progression of cognitive impai...
Sandhya Kiran Pemmasani,Shakthiraju R G,Suraj V et al.
Sandhya Kiran Pemmasani et al.
Genetic factors play a significant role in determining an individual's longevity. The present study was aimed at identifying genetic variants associated with longevity in Indian population. Long living individuals (LLIs), aged 85+, were com...
Mapping computational cognitive profiles of aging to dissociable brain and sociodemographic factors [0.03%]
计算认知老化图谱与解离脑和社会人口因素的关系mapping computational cognitive profiles of aging to dissociable brain and sociodemographic factors
Aleya A Marzuki,Kean Yung Wong,Jee Kei Chan et al.
Aleya A Marzuki et al.
Aging is associated with declines in cognition and brain structural integrity. However, there is equivocality over (1) the specificity of affected domains in different people, (2) the location of associated patterns of brain structural dete...
The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression [0.03%]
动态表观遗传景观在衰老中作用：协调SASP表达
Nirmalya Dasgupta,Rouven Arnold,Anais Equey et al.
Nirmalya Dasgupta et al.
Senescence and epigenetic alterations stand out as two well-characterized hallmarks of aging. When cells become senescent, they cease proliferation and release inflammatory molecules collectively termed the Senescence-Associated Secretory P...
Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain [0.03%]
小鼠脑内少突胶质前体细胞的衰老与分化命运
Paul T Gomez,Chase M Carver,Sonia L Rodriguez et al.
Paul T Gomez et al.
Age-related changes in oligodendrocyte precursor cells (OPCs) contribute to white matter dysfunction. In aged mice, we hypothesized that myelin-dense fimbria OPCs possess niche-specific properties, compared to hippocampal OPCs. Aged fimbria...
Mandy O J Grootaert
Mandy O J Grootaert
Cellular senescence has been implicated in many age-related pathologies including atherosclerosis, heart failure, age-related cardiac remodeling, diabetic cardiomyopathy and the metabolic syndrome. Here, we will review the characteristics o...
p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injury [0.03%]
衰老和急性损伤中衰老标志物P21V1和P21V2的P53依赖性
Parmita Kar,Ashok Sivasailam,Rupa Lavarti et al.
Parmita Kar et al.
The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine vari...
The impact of blood pressure lowering agents on the risk of worsening frailty among patients with diabetes mellitus: a cohort study [0.03%]
降压药对糖尿病患者虚弱恶化的风险影响：队列研究
Jui Wang,Szu-Ying Lee,Chia-Ter Chao et al.
Jui Wang et al.
Patients with diabetes mellitus (DM) are at risk of developing frailty, but studies rarely addressed risk factors for frailty worsening. We investigated whether blood pressure (BP)-lowering agents influenced such risk in these patients. Adu...