Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study [0.03%]
二甲双胍给药可改善老年烧伤患者预后：一项单中心队列研究
Dalia Barayan,Fadi Khalaf,Sarah Rehou et al.
Dalia Barayan et al.
This study assesses the safety and efficacy of metformin administration in older adult burn patients, a rapidly growing demographic with substantially poorer outcomes. This is a single-centre cohort study of older adults (≥60 years) admitt...
Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia [0.03%]
C1QA，C1QB，C1QC和C5AR1失调作为血管性痴呆候补生物标志物的候选对象
Yawen Xu,Hailing Zhang,Xuehao Jiao et al.
Yawen Xu et al.
Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate the...
Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors [0.03%]
初诊时的免疫衰老决定儿童白血病幸存者的T细胞恢复能力
Kavita M Dhodapkar,Sharon Castellino,Shivani Kapadia et al.
Kavita M Dhodapkar et al.
We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (n = 251) from uniformly...
A 50-year journey in the development of treatment for benign prostatic hyperplasia [0.03%]
良性前列腺增生治疗五十年发展之旅
Andrew V Schally,George Theodoropoulos,Wei Sha et al.
Andrew V Schally et al.
Recent research underscores the crucial role of hormone regulation in benign prostatic hyperplasia (BPH) and the therapeutic promise of growth hormone-releasing hormone (GH-RH) antagonists. BPH incidence in aging men doubled over three deca...
Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice [0.03%]
横断面及纵向研究发现代谢组生物标志物脆弱指数(frailty index)与衰老小鼠性别之间的关系
Dantong Zhu,Judy Z Wu,Patrick T Griffin et al.
Dantong Zhu et al.
Frailty is an age-related geriatric syndrome. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA mice, measured frailty index and derived metabolomics data from plasma. We identify age-related differenti...
Ronan Bennett,Marco Morselli,Kseniya Petrova et al.
Ronan Bennett et al.
DNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in develo...
Sex-specific insights into drug-induced lifespan extension and weight loss in mice [0.03%]
小鼠药物延长寿命和减肥的性别特异性研究见解
Aleksey V Belikov,Angelo Talay,João Pedro de Magalhães
Aleksey V Belikov
The DrugAge database serves as a comprehensive resource for studying compounds that increase lifespan in model organisms. In the latest version of DrugAge, we implemented multiple updates, predominantly focusing on mouse studies to enhance ...
Bidirectional association between physical activity and sleep in healthy Japanese super-seniors: the Japan Healthy Aging Study (J-HAS) [0.03%]
健康日本超高龄人群中的身体活动与睡眠的双向关系：来自日本健康老龄化研究（J-HAS）的数据
Helena Pham,Thomas Svensson,Ung-Il Chung et al.
Helena Pham et al.
To address the challenges of an ageing population, it is important to promote health by identifying factors for healthy ageing. The aim of this study was to investigate the bidirectional association between physical activity (PA) and sleep ...
Zeynep Elif Yesilyurt-Dirican,Ce Qi,Yi-Chian Wang et al.
Zeynep Elif Yesilyurt-Dirican et al.
Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues and organs with aging contribute to many chronic diseases, mainly through the secretion of a pro-inflammatory senescenc...
Wearable sleep recording augmented by artificial intelligence for Alzheimer's disease screening [0.03%]
基于人工智能的可穿戴睡眠记录用于阿尔茨海默病筛查
Elisabeth R M Heremans,Astrid Devulder,Pascal Borzée et al.
Elisabeth R M Heremans et al.
The recent emergence of wearable devices will enable large scale remote brain monitoring. This study investigated whether multimodal wearable sleep recordings could help screening for Alzheimer's disease (AD). Measurements were acquired sim...