Nothobranchius furzeri: a vertebrate model for studying cardiac aging and cellular senescence [0.03%]
诺特定ibranchius furzeri：研究心脏衰老和细胞衰老的脊椎动物模型
Xueling Ma,Yonghe Ding,David Mondaca-Ruff et al.
Xueling Ma et al.
African turquoise killifish (Nothobranchius furzeri) is the shortest-lived vertebrate that can be bred in captivity, making it an ideal model organism for aging studies. However, whether the animal can be used for studying cardiac aging and...
Elisabetta Di Fede,Esi Taci,Silvia Castiglioni et al.
Elisabetta Di Fede et al.
Cellular senescence represents a permanent state of cell cycle arrest, also observed in neurodegenerative disorders. As p300 has been identified as an epigenetic driver of replicative senescence, we aimed to investigate whether in vitro p30...
Aging-associated alterations in gene regulatory networks associate with risk, prognosis and response to therapy in lung adenocarcinoma [0.03%]
基因调控网络老化相关改变与肺腺癌风险、预后及治疗反应的关系
Enakshi Saha,Marouen Ben Guebila,Viola Fanfani et al.
Enakshi Saha et al.
Aging is the primary risk factor for many cancer types, including lung adenocarcinoma (LUAD). To understand how aging-related alterations in the regulation of key cellular processes might affect LUAD risk and survival, we built individual-s...
Psilocybin treatment extends cellular lifespan and improves survival of aged mice [0.03%]
裸盖菇素治疗延长细胞寿命并提高老年小鼠的存活率
Kosuke Kato,Jennifer M Kleinhenz,Yoon-Joo Shin et al.
Kosuke Kato et al.
Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative ind...
Walking into aging: real-world mobility patterns and digital benchmarks from the InCHIANTI Study [0.03%]
老龄化下的出行模式：来自意大利健康与老龄化研究的数据基准分析
Jose Albites-Sanabria,Pierpaolo Palumbo,Stefania Bandinelli et al.
Jose Albites-Sanabria et al.
Mobility is a cornerstone of health and quality of life, particularly in older adults. Digital mobility outcomes (DMOs) from real-world walking data offer crucial insights into the functional status and early markers of mobility decline. Th...
Identification of markers for neurescence through transcriptomic profiling of postmortem human brains [0.03%]
通过死后人脑转录组分析鉴定神经发生标志物
Shiva Kazempour Dehkordi,Sogand Sajedi,Amirreza Heshmat et al.
Shiva Kazempour Dehkordi et al.
Neuronal senescence (i.e., neurescence) is an important hallmark of aging and neurodegeneration, but it remains poorly characterized in the human brain due to the lack of reliable markers. This study aimed to identify neurescence markers ba...
Years since menopause and its metabolomic signature with biological aging in women at midlife: a population-based study [0.03%]
绝经年限及其与女性中年期生理性衰老的代谢标志：基于人口的队列研究
Bo Xie,Meiling Li,Qi Wang et al.
Bo Xie et al.
This study analyzed UK Biobank data from 46,463 postmenopausal women to investigate metabolic changes linked to years since menopause (YSM) and their impact on aging biomarkers. Elastic net regression identified 115 YSM-associated metabolit...
Potential of biomarkers of ageing in predicting severity of influenza virus infection and vaccination efficacy [0.03%]
生物衰老标志物预测流感病毒感染严重性和疫苗效力的潜在作用
Jing Yang,Wei Ren,Yi Ren et al.
Jing Yang et al.
Influenza virus infection contributing to the majority of viral pneumonia, acute cardiovascular and renal co-morbidities even death, is a worldwide public health concern caused by seasonal and pandemic influenza viruses. Unlike seasonal inf...
Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging [0.03%]
免疫代谢与氧化应激：在癌症和衰老中的作用及治疗策略
Nan-Jie Zhou,Wei-Qian Bao,Cui-Fen Zhang et al.
Nan-Jie Zhou et al.
Immunometabolism, encompassing metabolic processes within the immune system, plays a pivotal role in modulating the development, activity, and function of immune cells. Oxidative stress, resulting from an imbalance between pro-oxidants and ...
Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis-infection in age: addressing role of stress resistance and microbiome [0.03%]
单不饱和脂肪酸通过减轻压力和调节菌群改善牙周炎全身影响
Annika Döding,Ludwig Wurschi,Cristina Zubiria-Barrera et al.
Annika Döding et al.
Periodontitis (PD) is an age-associated infectious periodontal disease driven by dysbiosis and hyperinflammatory host response, resulting in bone and tissue loss. Often linked to systemic inflammatory comorbidities, modulating host response...