Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging [0.03%]
健康老化过程中alpha和beta振荡的年龄相关变化支持语义加工的保持性
Megan C Hall,Maggie P Rempe,Chloe C Casagrande et al.
Megan C Hall et al.
Semantic processing remains relatively preserved during healthy aging, but the mechanisms are poorly understood. Herein, we use dynamic functional mapping based on magnetoencephalography to examine the neural oscillations serving semantic p...
Endo180 and basement membrane stiffness induce OXPHOS and neoplastic transformation in aging prostate epithelia [0.03%]
老龄前列腺上皮细胞的内膜180和基底膜刚度可诱导氧化磷酸化和新生物转化
Lucia Pastro,Jennyfer Martínez,Santiago Fontenla et al.
Lucia Pastro et al.
During prostate aging collagen-IV is modified by advanced glycation end-products, inducing crosslinking of the basement membrane surrounding glandular acini. Basement membrane stiffness sensed by Endo180 disrupts its suppressor complex with...
A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers - a pilot study [0.03%]
卡路里限制或可延缓糖基化终产物的累积：一项为期两年的初步研究
Tea Pribić,Jayanta K Das,Lovorka Đerek et al.
Tea Pribić et al.
In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C...
A novel deep learning-based brain age prediction framework for routine clinical MRI scans [0.03%]
一种基于深度学习的新型大脑年龄预测框架用于常规临床MRI扫描
Hyunwoong Kim,Seongbeom Park,Sang Won Seo et al.
Hyunwoong Kim et al.
Physiological brain aging is associated with cognitive impairment and neuroanatomical changes. Brain age prediction of routine clinical 2D brain MRI scans were understudied and often unsuccessful. We developed a novel brain age prediction f...
Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging [0.03%]
局部放射治疗与癌症患者的染色体Y镶嵌型丢失有关，这是男性衰老的标志
Takuro Kobayashi,Tsuyoshi Hachiya,Yan Lu et al.
Takuro Kobayashi et al.
Mosaic loss of chromosome Y (mLOY) is the most common somatic mutation in hematopoietic cells of aging men and is linked to cancer risk and mortality. However, its relationship with treatment modalities remains unclear. In 348 prostate canc...
Identifying people with potentially undiagnosed dementia with Lewy bodies using natural language processing [0.03%]
利用自然语言处理技术识别潜在未诊断的路易体痴呆患者
Mohamed Heybe,Lucy Gibson,Annabel C Price et al.
Mohamed Heybe et al.
Natural language processing (NLP) can expand the utility of clinical records data in dementia research. We deployed NLP algorithms to detect core features of dementia with Lewy bodies (DLB) and applied those to a large database of patients ...
Modifiable traits and genetic associations with grey matter volume in mid-to-late adulthood: a population-based study in the UK biobank [0.03%]
英国生物样本库中影响中老年人大脑灰质体积的功能和遗传因素研究
Guoqing Pan,Yi Zhang,Ju-Jiao Kang et al.
Guoqing Pan et al.
Given the growing global elderly population and the accelerating decrease in grey matter volume (GMV) with age, understanding healthy brain aging is increasingly important. This study investigates whether variations in modifiable traits can...
Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences [0.03%]
一种解释性深度学习框架：了解阿尔茨海默病患者的脑部分子变化及其对小胶质细胞活化和性别差异的意义
Maitry Ronakbhai Trivedi,Amogh Manoj Joshi,Jay Shah et al.
Maitry Ronakbhai Trivedi et al.
The utilization of artificial intelligence in studying the dysregulation of gene expression in Alzheimer's disease (AD) affected brain tissues remains underexplored, particularly in delineating common and specific transcriptomic signatures ...
Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer [0.03%]
沉默调节蛋白与卵巢衰老相关纤维化易患卵巢癌的关系
Arkadiusz Grzeczka,Agnieszka Skowronska,Sara Sepe et al.
Arkadiusz Grzeczka et al.
The pursuit of understanding early genetic or protein markers for ovarian aging has garnered considerable attention in the realm of reproductive medicine. Sirtuins (SIRTs) are a group of proteins that are NAD+-dependent, and thanks to their...
The Rab3 family proteins in age-related neurodegeneration: unraveling molecular pathways and potential therapeutic targets [0.03%]
Rab3家族蛋白在年龄相关神经退行性疾病中的作用：揭示分子通路及潜在治疗靶点
Haijun He,Ruixue Ai,Evandro Fei Fang et al.
Haijun He et al.
The Rab3 protein family is composed of a series of small GTP-binding proteins, including Rab3a, Rab3b, Rab3c, and Rab3d, termed Rab3s. They play crucial roles in health, including in brain function, such as through the regulation of synapti...