Spine age estimation using deep learning in lateral spine radiographs and DXA VFA to predict incident fracture and mortality [0.03%]
基于深部学习的侧位脊柱X射线和DEXA腰椎骨密度影像的脊柱年龄估计，以预测骨折和死亡事件
Sang Wouk Cho,Namki Hong,Kyoung Min Kim et al.
Sang Wouk Cho et al.
Spine age estimated from lateral spine radiographs and DXA VFAs could be associated with fracture and mortality risk. In the VERTE-X cohort (n = 10,341, derivation set) and KURE cohort (n = 3517; external test set), spine age discriminated ...
Timing and duration of calorie restriction determine its impact on ovarian aging in female mice [0.03%]
卡路里限制对雌性小鼠卵巢衰老的影响取决于其持续时间及持续时长
Juliane B Prosczek,Jéssica D Hense,Driele N Garcia et al.
Juliane B Prosczek et al.
This study investigated how the timing and duration of 30% caloric restriction (CR) affect ovarian aging in mice. Mice were assigned to one of four groups: ad libitum (AL) control, long-term CR (3-11 months; CR/CR), early short-term CR (3-7...
A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans [0.03%]
线虫中一种百岁单核苷酸多态性位点COL25A1变异促进了寿命延长
Anita Goyala,Cyril Statzer,Ji Young Cecilia Park et al.
Anita Goyala et al.
Before human genome sequencing, a genome-wide study of sibling centenarian pairs identified a longevity-associated locus on chromosome 4. Here, we mapped the genes in this locus and identified a collagen gene, COL25A1. Introducing an SNP li...
Decoding skin aging: the role of KNG1 in collagen and elastic fibre degradation [0.03%]
解码皮肤衰老：KNG1在胶原蛋白和弹性纤维降解中的作用
Xinyue Zhang,Xinyu Yang,Xiaoran Liu et al.
Xinyue Zhang et al.
Kininogen-1 (KNG1) is an important pro-inflammatory and pro-oxidant factor, but its precise role in skin aging remains inadequately elucidated. Quantitative 4D proteomic-sequencing analysis identified upregulated KNG1 in 3- and 15-month-old...
Mitochondrial respiratory chain deficiency is associated with an impaired skeletal muscle regenerative response and fibrosis in older men with HIV [0.03%]
线粒体呼吸链缺陷与老年HIV男性骨骼肌再生应答受损和纤维化有关
Matthew Hunt,Amy E Vincent,Megan M McNiff et al.
Matthew Hunt et al.
Despite suppressive anti-retroviral therapy (ART), some older people with HIV show adverse ageing phenotypes, and the underlying mechanisms remain incompletely understood. We recruited 30 men with HIV aged ≥ 50 years and 15 well-matched me...
Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the Global Burden of Disease Study 2021 [0.03%]
绝经后妇女骨质疏松症的全球流行病学和疾病负担：来自2021年全球疾病负担研究的见解
Haofeng Liang,Shibo Chen,Meiling Shi et al.
Haofeng Liang et al.
Osteoporosis, primarily characterized by low bone mineral density (LBMD), is a major skeletal disorder among postmenopausal women (PMW), yet its global burden remains poorly quantified. Leveraging data from the Global Burden of Disease (GBD...
Deep learning of conversation-based 'filmstrips' for robust Alzheimer's disease detection [0.03%]
基于对话的“连环画”深度学习在阿尔茨海默病中的应用研究
Arthur Trognon,Coralie Duman,Gwladys Vittart et al.
Arthur Trognon et al.
Early detection of Alzheimer's disease remains complex and costly despite advancements in neurobiological markers. We propose an innovative approach based on the topological and kinetic analysis of verbal exchanges to distinguish patients f...
Modulating biological aging with food-derived signals: a systems and precision nutrition perspective [0.03%]
从系统营养和精准营养的角度用食物信号调节生物衰老
Carsten Carlberg,Andreas Blüthner,Irini Schoeman-Giziakis et al.
Carsten Carlberg et al.
Lifespan extension has not prevented age-related decline. We propose that diet acts as a molecular modulator of aging, influencing inflammation, the microbiome, and systemic resilience. Biological age markers and AI-powered multi-omics reve...
Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization [0.03%]
表观遗传学年龄加速与中年认知：来自观察性研究和孟德尔随机化联合证据
Yang Pan,Zhijie Huang,Xiao Sun et al.
Yang Pan et al.
The relationship between epigenetic age acceleration (EAA) and midlife cognitive function remains unclear, with limited causal evidence. We investigated this association in 1252 Black and White middle-aged adults from the Bogalusa Heart Stu...
Author Correction: Identification of markers for neurescence through transcriptomic profiling of postmortem human brains [0.03%]
作者更正：通过死后人脑转录组分析鉴定神经发生标志物
Shiva Kazempour Dehkordi,Sogand Sajedi,Amirreza Heshmat et al.
Shiva Kazempour Dehkordi et al.
Published Erratum
npj aging. 2025 Aug 12;11(1):74. DOI:10.1038/s41514-025-00262-9 2025