Dietary metabolomic determinants of frailty through inflammation in the Canadian Longitudinal Study on Aging [0.03%]
Talha Rafiq,Jinhui Ma,Divya Joshi et al.
Talha Rafiq et al.
Frailty is a modifiable aging-related condition driven by chronic inflammation and metabolic dysregulation, which are influenced by diet. Metabolomic profiling captures individual metabolic responses and can uncover mechanisms linking diet ...
Trajectories of physical function and biological aging in generally healthy older adults with and without incident invasive cancer over a three-year follow-up: findings from the DO-HEALTH study [0.03%]
Wiebke Rösler,Melanie Kistler-Fischbacher,Stephanie Gängler et al.
Wiebke Rösler et al.
Cancer is associated with biological aging and functional decline; however, few studies have simultaneously examined objective changes in physical function and biological aging in older adults who develop cancer. We therefore compared funct...
Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction [0.03%]
Michio Sato,Daishi Tanabu,Daisuke Torigoe et al.
Michio Sato et al.
Mitochondria play a central role in cellular energy metabolism and homeostasis, and their dysfunction is closely linked to the progression of age-related diseases. The mitochondrial ubiquitin ligase MITOL (also known as MARCHF5) is a key re...
Electrocardiogram derived heart age models agreement, accuracy and predictive ability in the Tromsø study [0.03%]
Arya Panthalanickal Vijayakumar,Tom Wilsgaard,Henrik Schirmer et al.
Arya Panthalanickal Vijayakumar et al.
Convolutional neural networks (CNNs) can estimate electrocardiogram (ECG)-based heart age. We compared three published CNNs in the Tromsø Study cohort (7,108 participants) for accuracy, agreement, and prognostic value. Mean absolute error ...
Samir I Aisin,Boris V Lidskii,Peter V Lidsky
Samir I Aisin
The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus only on reversing aging in older individuals, or paus...
Blanca Gonzalez-Garcia,Cristina Aparicio,Rocio Abia et al.
Blanca Gonzalez-Garcia et al.
Mesenchymal stem cells (MSCs) in bone marrow (BM) play a role in the development of BM adipose tissue (BMAT). Here, we propose ways to restock the BM-MSC niche to meet the needs of BMAT in ageing, including the activation of pluripotent pre...
Hydroxychloroquine alleviates cyclophosphamide-induced premature ovarian failure by attenuating granulosa cell senescence and modulating the mtDNA-cGAS pathway [0.03%]
Dehui Su,Ruiqiong Ma,Huina Su et al.
Dehui Su et al.
Cyclophosphamide (CTX) is a first-line chemotherapeutic agent for various cancers but is associated with a significant risk of ovarian dysfunction, which may even progress to premature ovarian failure (POF). Granulosa cell senescence is a k...
Urbanization, environment, and inflammaging: insights from sub-Saharan Africa [0.03%]
城市化、环境与炎性衰老：东非的启示
Stephen W Bickler,Matchecane Cossa,Irina Mendes de Sousa et al.
Stephen W Bickler et al.
Emerging evidence shows that inflammaging varies across populations, challenging universal immune-aging models. Urbanization in sub-Saharan Africa-characterized by reduced exposure to infectious diseases and rising rates of noncommunicable ...
DeepStrataAge: an interpretable deep-learning clock that reveals stage- and sex-divergent DNA methylation aging dynamics [0.03%]
深层年龄表观遗传时钟：具有可解释性的深度学习算法揭示了阶段特异性和性别差异DNA甲基化衰老动力学
Aaron Lin,Ilinca Giosan,Andrea Aparicio et al.
Aaron Lin et al.
Aging is the strongest risk factor for chronic diseases such as cardiovascular disease, Alzheimer's, and cancer. DNA methylation (DNAm) clocks offer a promising measure of biological age, but most rely on linear models that miss non-linear ...
Multifunctionality of TIM-3: from immunological aging to pathological progression [0.03%]
TIM-3的功能多样性：从免疫衰老到病理进展
Berta Segura-Collar,Lucía Mondejar-Ruescas,Carmen Jareño-Bonilla et al.
Berta Segura-Collar et al.
The connection between aging and immune dysfunction is uncovering how immunoaging processes contribute to disease. Recent data from Alzheimer’s disease, Parkinson’s disease, and adult and pediatric glioblastomas reveal a novel role for TI...