Counting steps [0.03%]
计步器数据分析挑战赛
Jeffrey S Johnson
Jeffrey S Johnson
The use of step count as a metric of synthetic efficiency carries opportunities and challenges. Here, proposals are made to standardize what constitutes a synthetic step and how steps are counted. These proposals may be beneficial in the ho...
Unveiling the impact of the light-source and steric factors on [2+2] heterocycloaddition reactions [0.03%]
揭秘光源及空间位阻因素对[[2+2]]周环异构加成反应的影响研究
Javier Mateos,Francesco Rigodanza,Paolo Costa et al.
Javier Mateos et al.
Information gained from in-depth mechanistic investigations can be used to control the selectivity of reactions, leading to the expansion of the generality of synthetic processes and the discovery of new reactivity. Here, we investigate the...
Combined radical and ionic approach for the enantioselective synthesis of β-functionalized amines from alcohols [0.03%]
醇的enantioselective合成映异构β-功能化胺的自由基/离子方法组合策略
Kai Lang,Yang Hu,Wan-Chen Cindy Lee et al.
Kai Lang et al.
Chiral amines are among the most important organic compounds and have widespread applications. Enantioselective construction of chiral amines is a major aim in organic synthesis. Among synthetic methods, direct functionalization of omnipres...
Enantiodivergent epoxidation of alkenes with a photoswitchable phosphate manganese-salen complex [0.03%]
具有光开关功能的磷酸猛沙仑复合物对烯烃的不对称发散式环氧化反应
Xiaofei Chen,Pieter J Gilissen,Paul Tinnemans et al.
Xiaofei Chen et al.
The development of enantiodivergent catalysts capable of preparing both enantiomeric products from one substrate in a controlled fashion is challenging. Introducing a switching function into the catalyst can address this challenge, allowing...
Synthesis of (+)-ribostamycin by catalytic, enantioselective hydroamination of benzene [0.03%]
苯的催化不对称氢胺化合成（+）-ribostamycin
Chad N Ungarean,Petra Galer,Yu Zhang et al.
Chad N Ungarean et al.
Aminoglycosides (AGs) represent a large group of pseudoglycoside natural products, in which several different sugar moieties are harnessed to an aminocyclitol core. AGs constitute a major class of antibiotics that target the prokaryotic rib...
Justin Jurczyk,Jisoo Woo,Sojung F Kim et al.
Justin Jurczyk et al.
Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought after, especially at the drug discovery stage, is the ability to enact the desired chemical transformations in a concise and chemospecific fashion. T...
Stereospecific α-(hetero)arylation of sulfoximines and sulfonimidamides [0.03%]
硫氧亚胺和磺酰亚胺胺的立体选择性α-(杂)芳基化反应
Zachary P Shultz,Thomas Scattolin,Lukasz Wojtas et al.
Zachary P Shultz et al.
The occurrence of sulfoximines and sulfonimidoyl groups in biologically active molecules within pharmaceuticals and agrochemicals has notably increased in the past decade. This increase has prompted a wave of discovery of methods to install...
Combining chemistry and protein engineering for new-to-nature biocatalysis [0.03%]
结合化学和蛋白质工程创造非天然生物催化剂
David C Miller,Soumitra V Athavale,Frances H Arnold
David C Miller
Biocatalysis, the application of enzymes to solve synthetic problems of human import, has blossomed into a powerful technology for chemical innovation. In the past decade, a threefold partnership, where nature provides blueprints for enzyma...