Simona Bianco,Fin Hallam Stewart,Santanu Panja et al.
Simona Bianco et al.
The design of supramolecular hydrogels comprising aligned domains is important for the fabrication of biomimetic materials and applications in optoelectronics. One way to access such materials is by the self-assembly of small molecules into...
Mechanistic insight into benzylidene-directed glycosylation reactions using cryogenic infrared spectroscopy [0.03%]
利用低温红外光谱研究苯乙烯基导向的糖苷化反应机制
Chun-Wei Chang,Kim Greis,Gurpur Rakesh D Prabhu et al.
Chun-Wei Chang et al.
The stereoselective formation of 1,2-cis glycosidic linkages is challenging. The currently most widely used strategy for their installation uses 4,6-O-benzylidene-protected building blocks. The stereoselectivity of this reaction is thought ...
Reproducible high-quality perovskite single crystals by flux-regulated crystallization with a feedback loop [0.03%]
具有反馈回路的熔剂调节结晶制备可再现高质量钙钛矿单晶
Yuki Haruta,Hanyang Ye,Paul Huber et al.
Yuki Haruta et al.
Controlling the linear growth rate, a critical factor that determines crystal quality, has been a challenge in solution-grown single crystals due to complex crystallization kinetics influenced by multiple parameters. Here we introduce a flu...
Engineering non-haem iron enzymes for enantioselective C(sp3)-F bond formation via radical fluorine transfer [0.03%]
通过自由基氟转移工程化非血红素铁酶以形成对映选择性的C(sp3)-F键
Qun Zhao,Zhenhong Chen,Jordi Soler et al.
Qun Zhao et al.
In recent years there has been a surge in the development of methods for the synthesis of organofluorine compounds. However, enzymatic methods for C-F bond formation have been limited to nucleophilic fluoride substitution. Here, we report t...
Biocatalytic, Stereoconvergent Alkylation of (Z/E)-Trisubstituted Silyl Enol Ethers [0.03%]
(Z/E)三取代硅基烯醇醚的生物催化叠氮
Runze Mao,Doris Mia Taylor,Daniel J Wackelin et al.
Runze Mao et al.
Alkene functionalization has garnered significant attention due to the versatile reactivity of C=C bonds. A major challenge is the selective conversion of isomeric alkenes into chiral products. Researchers have devised various biocatalytic ...
Synthesis of nimbolide and its analogues and their application as poly(ADP-ribose) polymerase-1 trapping inducers [0.03%]
尼敏菲啶及其类似物的合成及PARP-1捕捉诱导剂研究中的应用
Heping Deng,Hejun Deng,Chiho Kim et al.
Heping Deng et al.
Nimbolide, a ring seco-C limonoid natural product, was recently found to inhibit the poly(ADP)-ribosylation (PARylation)-dependent ubiquitin E3 ligase RNF114. In doing so, it induces the 'supertrapping' of both PARylated PARP1 and PAR-depen...
Trever M Bostelaar,Alexandra C Brown,Arun Sridharan et al.
Trever M Bostelaar et al.
The deployment of metalloclusters in applications such as catalysis and materials synthesis requires robust methods for site-differentiation: the conversion of clusters with symmetric ligand spheres to those with unsymmetrical ligand sphere...
Generation and reactivity of unsymmetrical strained heterocyclic allenes [0.03%]
应变杂环不对称亚烯烃的生成及反应性研究
Andrew V Kelleghan,Arismel Tena Meza,Neil K Garg
Andrew V Kelleghan
Strained cyclic allenes are short-lived intermediates that confine a functional group with a preferred linear geometry, an allene, into a small ring, inducing strain-driven reactivity. Nitrogen-containing variants, or azacyclic allenes, hav...
Accessing three-dimensional molecular diversity through benzylic C-H cross-coupling [0.03%]
通过苄基C-H交叉偶联获取三维分子多样性
Si-Jie Chen,Cyndi Qixin He,May Kong et al.
Si-Jie Chen et al.
Pharmaceutical and agrochemical discovery efforts rely on robust methods for chemical synthesis that rapidly access diverse molecules1,2. Cross-coupling reactions are the most widely used synthetic methods3, but these methods typically form...
Enzymes on Steroids [0.03%]
类固醇酶
Liupeng Zhao,Zhiyu Bo,Yang Yang
Liupeng Zhao
Efficient assembly and functionalization of biologically active steroids continue to pose a significant synthetic hurdle. The mining and engineering of selective P450 C-H hydroxylases combined with chemoenzymatic synthesis furnished a new s...