Biocatalytic, Stereoconvergent Alkylation of (Z/E)-Trisubstituted Silyl Enol Ethers [0.03%]
(Z/E)三取代硅基烯醇醚的生物催化叠氮
Runze Mao,Doris Mia Taylor,Daniel J Wackelin et al.
Runze Mao et al.
Alkene functionalization has garnered significant attention due to the versatile reactivity of C=C bonds. A major challenge is the selective conversion of isomeric alkenes into chiral products. Researchers have devised various biocatalytic ...
Synthesis of nimbolide and its analogues and their application as poly(ADP-ribose) polymerase-1 trapping inducers [0.03%]
尼敏菲啶及其类似物的合成及PARP-1捕捉诱导剂研究中的应用
Heping Deng,Hejun Deng,Chiho Kim et al.
Heping Deng et al.
Nimbolide, a ring seco-C limonoid natural product, was recently found to inhibit the poly(ADP)-ribosylation (PARylation)-dependent ubiquitin E3 ligase RNF114. In doing so, it induces the 'supertrapping' of both PARylated PARP1 and PAR-depen...
Trever M Bostelaar,Alexandra C Brown,Arun Sridharan et al.
Trever M Bostelaar et al.
The deployment of metalloclusters in applications such as catalysis and materials synthesis requires robust methods for site-differentiation: the conversion of clusters with symmetric ligand spheres to those with unsymmetrical ligand sphere...
Generation and reactivity of unsymmetrical strained heterocyclic allenes [0.03%]
应变杂环不对称亚烯烃的生成及反应性研究
Andrew V Kelleghan,Arismel Tena Meza,Neil K Garg
Andrew V Kelleghan
Strained cyclic allenes are short-lived intermediates that confine a functional group with a preferred linear geometry, an allene, into a small ring, inducing strain-driven reactivity. Nitrogen-containing variants, or azacyclic allenes, hav...
Accessing three-dimensional molecular diversity through benzylic C-H cross-coupling [0.03%]
通过苄基C-H交叉偶联获取三维分子多样性
Si-Jie Chen,Cyndi Qixin He,May Kong et al.
Si-Jie Chen et al.
Pharmaceutical and agrochemical discovery efforts rely on robust methods for chemical synthesis that rapidly access diverse molecules1,2. Cross-coupling reactions are the most widely used synthetic methods3, but these methods typically form...
Enzymes on Steroids [0.03%]
类固醇酶
Liupeng Zhao,Zhiyu Bo,Yang Yang
Liupeng Zhao
Efficient assembly and functionalization of biologically active steroids continue to pose a significant synthetic hurdle. The mining and engineering of selective P450 C-H hydroxylases combined with chemoenzymatic synthesis furnished a new s...
Counting steps [0.03%]
计步器数据分析挑战赛
Jeffrey S Johnson
Jeffrey S Johnson
The use of step count as a metric of synthetic efficiency carries opportunities and challenges. Here, proposals are made to standardize what constitutes a synthetic step and how steps are counted. These proposals may be beneficial in the ho...
Unveiling the impact of the light-source and steric factors on [2+2] heterocycloaddition reactions [0.03%]
揭秘光源及空间位阻因素对[[2+2]]周环异构加成反应的影响研究
Javier Mateos,Francesco Rigodanza,Paolo Costa et al.
Javier Mateos et al.
Information gained from in-depth mechanistic investigations can be used to control the selectivity of reactions, leading to the expansion of the generality of synthetic processes and the discovery of new reactivity. Here, we investigate the...
Combined radical and ionic approach for the enantioselective synthesis of β-functionalized amines from alcohols [0.03%]
醇的enantioselective合成映异构β-功能化胺的自由基/离子方法组合策略
Kai Lang,Yang Hu,Wan-Chen Cindy Lee et al.
Kai Lang et al.
Chiral amines are among the most important organic compounds and have widespread applications. Enantioselective construction of chiral amines is a major aim in organic synthesis. Among synthetic methods, direct functionalization of omnipres...
Enantiodivergent epoxidation of alkenes with a photoswitchable phosphate manganese-salen complex [0.03%]
具有光开关功能的磷酸猛沙仑复合物对烯烃的不对称发散式环氧化反应
Xiaofei Chen,Pieter J Gilissen,Paul Tinnemans et al.
Xiaofei Chen et al.
The development of enantiodivergent catalysts capable of preparing both enantiomeric products from one substrate in a controlled fashion is challenging. Introducing a switching function into the catalyst can address this challenge, allowing...