Ikko Takahashi,Andreu Tortajada,David E Anderson et al.
Ikko Takahashi et al.
Sodium is one of the most abundant elements on Earth and a sustainable alternative to less sustainable metals such as lithium, which is becoming increasingly depleted and expensive. Traditionally, however, organosodium reagents have been co...
Difunctionalization of bicyclo[1.1.0]butanes enabled by merging C-C cleavage and ruthenium-catalysed remote C-H activation [0.03%]
通过结合C-C断裂和远程C-H活化实现环丁烷的双官能团化反应
Shan Chen,Zhimin Xu,Binbin Yuan et al.
Shan Chen et al.
The high fraction of sp 3-hybridized carbon atom (Fsp 3) character of cyclobutane derivatives renders them as highly promising bioisosteres for otherwise typically flat arenes. Here, to address the current needs in medicinal chemistry for F...
Ultrathin transition metal oxychalcogenide catalysts for oxygen evolution in acidic media [0.03%]
超薄过渡金属氧硫属化物催化剂在酸性介质中的析氧反应
Wenshuo Xu,Yao Wu,Shibo Xi et al.
Wenshuo Xu et al.
Two-dimensional transition metal dichalcogenides (TMDs) exfoliated from bulk layered materials possess interesting properties. Most transition metal oxides are not layered and therefore cannot be exfoliated. Here we report the synthesis of ...
An engineered aldolase enables the biocatalytic synthesis of 2'-functionalized nucleoside analogues [0.03%]
一种工程化丙酮酸醛缩酶使生物催化合成2' -功能核苷类似物成为可能
Matthew Willmott,William Finnigan,William R Birmingham et al.
Matthew Willmott et al.
Nucleosides functionalized at the 2'-position play a crucial role in therapeutics, serving as both small-molecule drugs and modifications in therapeutic oligonucleotides. However, the synthesis of these molecules often presents substantial ...
Biocatalytic enantioselective C(sp3)-H fluorination enabled by directed evolution of non-haem iron enzymes [0.03%]
非血红素铁酶定向进化催化的生物催化立体选择性sp3-CF键氟化反应
Liu-Peng Zhao,Binh Khanh Mai,Lida Cheng et al.
Liu-Peng Zhao et al.
Due to the scarcity of C-F bond forming enzymatic activities in nature and the contrasting ubiquity of organofluorine moieties in bioactive compounds, developing new biocatalytic fluorination reactions represents a preeminent challenge in e...
Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations [0.03%]
光促进的双环[1.1.1]戊烷卤化物的合成及其官能团化反应
Vasyl Ripenko,Vadym Sham,Vitalina Levchenko et al.
Vasyl Ripenko et al.
In 2012, bicyclo[1.1.1]pentanes were demonstrated to be bioisosteres of the benzene ring. Here, we report a general scalable reaction between alkyl iodides and propellane that provides bicyclo[1.1.1]pentane iodides in milligram, gram and ev...
Simona Bianco,Fin Hallam Stewart,Santanu Panja et al.
Simona Bianco et al.
The design of supramolecular hydrogels comprising aligned domains is important for the fabrication of biomimetic materials and applications in optoelectronics. One way to access such materials is by the self-assembly of small molecules into...
Mechanistic insight into benzylidene-directed glycosylation reactions using cryogenic infrared spectroscopy [0.03%]
利用低温红外光谱研究苯乙烯基导向的糖苷化反应机制
Chun-Wei Chang,Kim Greis,Gurpur Rakesh D Prabhu et al.
Chun-Wei Chang et al.
The stereoselective formation of 1,2-cis glycosidic linkages is challenging. The currently most widely used strategy for their installation uses 4,6-O-benzylidene-protected building blocks. The stereoselectivity of this reaction is thought ...
Reproducible high-quality perovskite single crystals by flux-regulated crystallization with a feedback loop [0.03%]
具有反馈回路的熔剂调节结晶制备可再现高质量钙钛矿单晶
Yuki Haruta,Hanyang Ye,Paul Huber et al.
Yuki Haruta et al.
Controlling the linear growth rate, a critical factor that determines crystal quality, has been a challenge in solution-grown single crystals due to complex crystallization kinetics influenced by multiple parameters. Here we introduce a flu...
Engineering non-haem iron enzymes for enantioselective C(sp3)-F bond formation via radical fluorine transfer [0.03%]
通过自由基氟转移工程化非血红素铁酶以形成对映选择性的C(sp3)-F键
Qun Zhao,Zhenhong Chen,Jordi Soler et al.
Qun Zhao et al.
In recent years there has been a surge in the development of methods for the synthesis of organofluorine compounds. However, enzymatic methods for C-F bond formation have been limited to nucleophilic fluoride substitution. Here, we report t...