Anti-Markovnikov hydro- and deuterochlorination of unsaturated hydrocarbons using iron photocatalysis [0.03%]
铁光催化剂用于不饱和烃的抗马尔可夫尼科夫氯化和氘代氯化反应
Kang-Jie Bian,David Nemoto Jr,Ying Chen et al.
Kang-Jie Bian et al.
Hydrochlorination of unsaturated hydrocarbons is a fundamental reaction scheme in organic synthesis, with the traditional acid-mediated approaches proceeding in Markovnikov selectivity and direct access to anti-Markovnikov hydrochlorination...
Reactions of a Zn-Zn bond with main group carbene analogues as a prototypical case of reductive addition [0.03%]
主族亚甲基类似物与Zn-Zn键反应的典型加成案例研究
Wenbang Yang,Andrew J P White,Mark R Crimmin
Wenbang Yang
Oxidative addition most commonly involves the addition of a substrate to a metal centre. This reaction is fundamental across synthetic chemistry and underpins numerous catalytic methods. In the textbook description of oxidative addition rea...
Synthesis of Chiral Carbocycles via Enantioselective β,γ-Dehydrogenation [0.03%]
手性碳环化合物的对映选择性β, γ-脱氢合成
Tao Sheng,Tao Zhang,Zhe Zhuang et al.
Tao Sheng et al.
Enantioselective dehydrogenation of prochiral C-H bonds could provide a powerful method for constructing chiral centers attached to synthetically versatile vinyl groups. Herein, we describe the realization of enantioselective β,γ-dehydrog...
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A [0.03%]
合成与超高分辨率核磁共振联用揭示西耶乐菌素A正确结构
Malcolm R P George,Max Deering,Daniele Fiorito et al.
Malcolm R P George et al.
Polyketide-derived natural products bearing repeat 1,5-polyols are commonly encountered but their structures are notoriously difficult to determine using spectroscopic techniques. The presence of distal 1,5-diol moieties frequently leads to...
Ikko Takahashi,Andreu Tortajada,David E Anderson et al.
Ikko Takahashi et al.
Sodium is one of the most abundant elements on Earth and a sustainable alternative to less sustainable metals such as lithium, which is becoming increasingly depleted and expensive. Traditionally, however, organosodium reagents have been co...
Difunctionalization of bicyclo[1.1.0]butanes enabled by merging C-C cleavage and ruthenium-catalysed remote C-H activation [0.03%]
通过结合C-C断裂和远程C-H活化实现环丁烷的双官能团化反应
Shan Chen,Zhimin Xu,Binbin Yuan et al.
Shan Chen et al.
The high fraction of sp 3-hybridized carbon atom (Fsp 3) character of cyclobutane derivatives renders them as highly promising bioisosteres for otherwise typically flat arenes. Here, to address the current needs in medicinal chemistry for F...
Ultrathin transition metal oxychalcogenide catalysts for oxygen evolution in acidic media [0.03%]
超薄过渡金属氧硫属化物催化剂在酸性介质中的析氧反应
Wenshuo Xu,Yao Wu,Shibo Xi et al.
Wenshuo Xu et al.
Two-dimensional transition metal dichalcogenides (TMDs) exfoliated from bulk layered materials possess interesting properties. Most transition metal oxides are not layered and therefore cannot be exfoliated. Here we report the synthesis of ...
An engineered aldolase enables the biocatalytic synthesis of 2'-functionalized nucleoside analogues [0.03%]
一种工程化丙酮酸醛缩酶使生物催化合成2' -功能核苷类似物成为可能
Matthew Willmott,William Finnigan,William R Birmingham et al.
Matthew Willmott et al.
Nucleosides functionalized at the 2'-position play a crucial role in therapeutics, serving as both small-molecule drugs and modifications in therapeutic oligonucleotides. However, the synthesis of these molecules often presents substantial ...
Biocatalytic enantioselective C(sp3)-H fluorination enabled by directed evolution of non-haem iron enzymes [0.03%]
非血红素铁酶定向进化催化的生物催化立体选择性sp3-CF键氟化反应
Liu-Peng Zhao,Binh Khanh Mai,Lida Cheng et al.
Liu-Peng Zhao et al.
Due to the scarcity of C-F bond forming enzymatic activities in nature and the contrasting ubiquity of organofluorine moieties in bioactive compounds, developing new biocatalytic fluorination reactions represents a preeminent challenge in e...
Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations [0.03%]
光促进的双环[1.1.1]戊烷卤化物的合成及其官能团化反应
Vasyl Ripenko,Vadym Sham,Vitalina Levchenko et al.
Vasyl Ripenko et al.
In 2012, bicyclo[1.1.1]pentanes were demonstrated to be bioisosteres of the benzene ring. Here, we report a general scalable reaction between alkyl iodides and propellane that provides bicyclo[1.1.1]pentane iodides in milligram, gram and ev...