Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease [0.03%]
缺血性心脏病患者的血浆和心包液代谢组学特征分析
Federica De Castro,Chiara Coppola,Egeria Scoditti et al.
Federica De Castro et al.
Background: Ischemic heart disease is the leading cause of global mortality. Despite advances in clinical management, current diagnostic tools do not capture early metabolic disturbances associated with myocardial ischemi...
Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity [0.03%]
转录组谱型分析和机器学习揭示银屑病的基因标志物及疾病严重程度
Ashley Rider,Henry J Grantham,Graham R Smith et al.
Ashley Rider et al.
Background: Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phenotypes and disease severity is poorly defined. Knowledge gaps include whether molecular endotypes of psoriasi...
5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer [0.03%]
5-甲基胞嘧啶和5-羟甲基胞嘧啶联合用于结直肠癌早期检测标志物
Fabio Puddu,Annelie Johansson,Aurélie Modat et al.
Fabio Puddu et al.
Background: Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. This study investigates the roles of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomar...
Foundation models enable wearable signal screening for cardiovascular disease among people living with HIV [0.03%]
基础模型使HIV感染者能够进行穿戴信号筛查以预防心血管疾病
Munib Mesinovic,Hai Ho Bich,Ly Vo Trieu et al.
Munib Mesinovic et al.
Background: Cardiovascular disease screening faces significant challenges in resource-limited settings, where infrastructure and computational constraints preclude advanced assessment. These constraints are particularly a...
Support for the wellbeing of frontline healthcare workers should be incorporated in health emergency preparedness planning [0.03%]
对一线医疗工作者福利的支持应纳入健康紧急情况防范规划中
Kate McNeil,Stephanie Nzekwu,Lucy Gilson et al.
Kate McNeil et al.
Health system resilience requires a resilient and well workforce. During health crises, including pandemics and outbreaks of pathogens, frontline healthcare workers can face significant challenges, resulting in personal psychosocial costs f...
Skeletal muscle transcriptional dysregulation of genes involved in senescence is associated with prognosis in severe heart failure [0.03%]
骨骼肌转录失调与严重心力衰竭预后有关
Eric Rullman,Alen Lovric,Michael Melin et al.
Eric Rullman et al.
Background: The skeletal muscle hypothesis refers to a vicious cycle of successive deterioration of left ventricular function, skeletal muscle remodeling, and functional capacity in patients with heart failure. Despite ex...
The radiotherapy induced cyclic GMP-AMP-synthase re-localization and immune signature predicts HNSCC treatment efficacy [0.03%]
放疗诱导的环GMP-AMP合成酶重定位和免疫特征预测头颈部肿瘤疗效
Vera E Mekers,Paul N Span,Maaike Looman et al.
Vera E Mekers et al.
Background: Radiotherapy (RT) is a crucial treatment for head and neck squamous cell carcinoma (HNSCC). Recent pre-clinical studies highlight the potential of combining RT with immunotherapy due to RT-induced activation o...
Deep learning for detecting depression in individuals with and without alexithymia [0.03%]
深度学习在识别亚历山德里亚症患者与非患者的抑郁症中的应用
Calvin Lam,Longdi Xian,Rong Huang et al.
Calvin Lam et al.
Background: To accurately detect individuals' mental health issues using artificial intelligence and self-report scales, it is crucial to recognize how personal characteristics can affect the detection. This study focuses...
The Reproductive Mental health of Ontario Virtual Intervention Network (MOVIN): a pilot randomized controlled trial [0.03%]
安大略虚拟干预网络(MOVIN):一项试点随机对照试验
S N Vigod,A Dalfen,C L Dennis et al.
S N Vigod et al.
Background: The Reproductive Mental health of Ontario Virtual Intervention Network (MOVIN) aims to improve perinatal depression care across a large Canadian health jurisdiction. It involves a web-based platform, care coor...
Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT) [0.03%]
利用生成式人工智能提高认知行为疗法(CBT)参与度的随机对照试验(RCT)
Jessica McFadyen,Johanna Habicht,Larisa-Maria Dina et al.
Jessica McFadyen et al.
Background: Shortages in mental healthcare lead to long periods of inadequate support for many patients. While digital interventions offer a scalable solution to this unmet clinical need, patient engagement remains a key ...