Influenza vaccine responses differ between young children previously exposed to influenza antigens via infection versus vaccination [0.03%]
Annette Fox,Annette Alafaci,Louise Carolan et al.
Annette Fox et al.
Background: Annual influenza vaccination is recommended for young children with limited understanding of how this may imprint influenza immunity. We conducted a pilot study to examine whether early life exposure to influe...
Bouwien Smits-Engelsman,Dané Coetzee,Rosemary Xorlanyo Doe-Asinyo et al.
Bouwien Smits-Engelsman et al.
Background: Africa is facing a rising prevalence of non-communicable diseases (NCDs), driven by shifts in lifestyle and dietary habits. Children with delays in motor coordination are less likely to participate in physical...
Simulation-based inference at the theoretical limit for fast, robust microstructural MRI with minimal diffusion data [0.03%]
Maximilian F Eggl,Silvia De Santis
Maximilian F Eggl
Background: Diffusion-weighted magnetic resonance imaging provides a non-invasive way to probe brain tissue microstructure and is widely used in neuroscience and clinical research. Reliable microstructural maps usually re...
Peripheral blood mononuclear cell DNA methylation signatures guide surgical decision-making in indeterminate pulmonary nodules [0.03%]
Haofan Yin,Ningfang Zhang,Lumei Qiu et al.
Haofan Yin et al.
Background: Distinguishing malignant from benign pulmonary nodules remained a significant clinical challenge. Given the involvement of DNA methylation in anti-tumor immunity, we aimed to investigated whether DNA methylati...
Systematic interrogation of drug sensitivities in melanoma reveals potent synergistic and antagonistic drug combinations with translational potential [0.03%]
Pilar Ayuda-Durán,Robert Hanes,Leiv Rønneberg et al.
Pilar Ayuda-Durán et al.
Background: Targeted therapies have become mainstream anticancer treatments, although their efficacy is limited by low response rates, drug resistance, and therapy-related toxicities. Drug combinations have the potential ...
Epidemiological impacts of nonpharmaceutical interventions are modulated by immunity exposure trade offs [0.03%]
Chadi M Saad-Roy,Bjarke Frost Nielsen,Margaret L Lind et al.
Chadi M Saad-Roy et al.
Background: The COVID-19 pandemic has illustrated how nonpharmaceutical interventions (NPIs), such as mask-wearing, social distancing, and purifying air, can successfully mitigate transmission and reduce infections in the...
Microbiome responses to anthelmintic treatment depend on pre-treatment helminth infection status in young Ethiopian children [0.03%]
Polina Tikhonova,Zeleke Mekonnen,Kenneth D Belanger et al.
Polina Tikhonova et al.
Background: Mass deworming programs using anthelmintic drugs are a common public health strategy for controlling soil-transmitted helminth (STH) infections in high-risk, low-income countries. However, whether routine dewo...
Nader Hirmas,Johannes Holtschmidt,Stephan Falk et al.
Nader Hirmas et al.
Breast cancer remains the most frequently diagnosed cancer among women worldwide, and its burden is particularly severe in regions affected by conflict and war. In these settings, oncology care is often disrupted by the destruction of healt...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID [0.03%]
Mark A Faghy,Rob C I Wüst,Daniel M Altmann et al.
Mark A Faghy et al.
Background: Viral and infectious illnesses can exert profound and enduring effects on population health and well-being. In the aftermath of SARS-CoV-2 infection, post-acute sequelae, collectively referred to as Long COVID...
Cyrus Lap Kwan Leung,Kin-Kit Li,Arthur Tang et al.
Cyrus Lap Kwan Leung et al.
Background: Timely vaccination effectively reduced COVID-19 hospitalizations and mortality, yet vaccination hesitancy undermined this benefit. Understanding the factors contributing to hesitancy is critical for improving ...