A comparative analysis of infection and mortality in reassessing africa's COVID-19 dynamic using time-varying tests [0.03%]
利用随时间变化的检测方法重新评估非洲新冠疫情的感染和死亡率的比较分析
Stéphane Luchini,Constantin Pfauwadel,Patrick A Pintus et al.
Stéphane Luchini et al.
Background: It is commonly believed that Africa largely evaded the worst of the COVID-19 pandemic, with fewer cases than other continents. However, regional comparisons that ignore differences in testing intensity may mis...
Pembrolizumab and epigenetic modification with azacitidine reshapes the tumor microenvironment of platinum-resistant epithelial ovarian cancer: a phase 2 non-randomized clinical trial [0.03%]
派姆单抗与地西他滨表观遗传学修饰治疗铂耐药性上皮卵巢癌：重塑肿瘤微环境的Ⅱ期非随机临床试验
Blair V Landon,Julia L Boland,Andrea E Wahner Hendrickson et al.
Blair V Landon et al.
Background: Epigenetic modulators may sensitize platinum-resistant ovarian cancer (PROC) to immune checkpoint inhibition by reprogramming the tumor microenvironment. ...
Integrative genomic and literature assessment of desmoglein 2-related arrhythmogenic cardiomyopathy with Italian cohort validation [0.03%]
与意大利队列验证相关的桥粒斑蛋白2相关性致心律失常性心肌病的整合基因组和文献评估
Serena Pinci,Rudy Celeghin,Marika Martini et al.
Serena Pinci et al.
Background: Desmoglein-2 (DSG2) is an essential cardiac desmosomal cadherin, and its alteration underlies a broad spectrum of arrhythmogenic cardiomyopathy (ACM). Yet, the clinical significance of many DSG2 variants remai...
Shuhao Qian,Lu Yang,Jia Meng et al.
Shuhao Qian et al.
Background: Before surgical resection of lung tumor, intraoperative biopsy is needed for cancer diagnosis, while current techniques that guide biopsy have limited performance in tumor identification and boundary determina...
Machine learning to infer neurocognitive testing scores among adolescents and young adults with congenital heart disease [0.03%]
机器学习在青少年及年轻成人中推断先天性心脏病患者的神经心理学检测结果
Mohammad Arafat Hussain,Sheng He,Heather R Adams et al.
Mohammad Arafat Hussain et al.
Background: Congenital heart disease (CHD) affects about 1% of births and is linked to differences in thinking and learning. Understanding how birth, genetic, clinical, and environmental factors together explain cognitive...
A computationally frugal, open-source chest CT foundation model for thoracic disease detection in lung cancer screening programmes [0.03%]
一种用于肺癌筛查项目的计算上节省且开源的胸部CT基础模型，以检测胸腔疾病
Niccolò McConnell,Pardeep Vasudev,Daisuke Yamada et al.
Niccolò McConnell et al.
Background: Low-dose computed tomography (LDCT) employed in lung cancer screening (LCS) programmes is increasing in uptake worldwide. LCS programmes herald a generational opportunity to simultaneously detect cancer and no...
Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions [0.03%]
遗传学识别肥胖是并发多种长期疾病的风险因素
Ninon Mounier,Bethany Voller,Jane A H Masoli et al.
Ninon Mounier et al.
Background: Multimorbidity, the co-occurrence of multiple long-term conditions (LTCs), is an increasingly important clinical problem, but little is known about the underlying causes. We investigate the role of a critical ...
Cross-sectional survey among professionals on communication and mental health care for asylum seeking and refugee minors in Germany [0.03%]
德国关于寻求庇护和难民未成年人沟通和精神卫生保健的横断面调查研究报告专业人士版
Anna Jael Esser,Jana Willems,Mia Klein et al.
Anna Jael Esser et al.
Background: Forced displacement and migration are on the rise worldwide. Asylum seeking and refugee minors (ASRM) are particularly exposed to risk factors for mental health problems. Yet, there is a lack of comprehensive ...
Deep neural network-based analysis of voice biomarkers for monitoring treatment response in adolescent major depressive disorder [0.03%]
基于深度神经网络的青少年重大抑郁障碍治疗反应监测语音生物标志物分析
June-Woo Kim,Haram Yoon,Bung-Nyun Kim et al.
June-Woo Kim et al.
Background: In adolescents, identifying objective biomarkers for treatment response is crucial for the development of effective interventions. Voice-based biomarkers have recently shown potential to capture treatment-rela...
The Nugent score is an inappropriate diagnostic tool for neovaginal bacteria in transfeminine people [0.03%]
尼根氏评分不适合作为跨性别女性新阴道细菌的诊断工具
Reeya Parmar,Bern Monari,Emery Potter et al.
Reeya Parmar et al.
Background: Many transfeminine people (assigned male at birth with feminine gender identities) undergo vaginoplasty, a surgical procedure constructing a neovagina, typically using penile and scrotal tissue. In cisgender f...