Machine learning-based cfDNA fragmentation profiling using automated capillary electrophoresis for early detection of hepatocellular carcinoma [0.03%]
基于机器学习的cfDNA片段组学分析在肝癌早筛中的应用研究——自动化毛细管电泳方法开发及临床验证
Sasimol Udomruk,Songphon Sutthitthasakul,Nuttida Bunsermvicha et al.
Sasimol Udomruk et al.
Background: Early detection of hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited sensitivity of current surveillance tools, alpha-fetoprotein (AFP) and ultrasound. Recently, cell-f...
Distinct prognostic value of [18F]FDG PET and [68Ga]Ga-PSMA-11 PET in advanced hormone-sensitive prostate cancer [0.03%]
[18F]FDG和[68Ga]Ga-PSMA-11显像在高危且激素敏感型前列腺癌中的预后价值不同
Ang Li,Haotian Wu,Xiang Zhou et al.
Ang Li et al.
Background: This study aimed to evaluate the distinct prognostic value of [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in advanced hormone-sensitive prostate cancer, highlighting their complementary roles at both patient and...
A machine learning model for optimizing treatment of patients with poorly controlled type 2 diabetes [0.03%]
用于优化2型糖尿病患者治疗的机器学习模型
Juan Shi,Cong Liu,Jiahang Hu et al.
Juan Shi et al.
Background: Cardiorenal-protective sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) lack selection guidance. We aimed to build a SGLT-2i/GLP-1RA Decision Score (T...
Nusinersen rescues taurine deficiency in patients with type 1 Spinal Muscular Atrophy [0.03%]
Nusinersen治疗脊髓性肌萎缩症能纠正低 tauroidinemia 状态
Raffaella di Vito,Amber Hassan,Tommaso Nuzzo et al.
Raffaella di Vito et al.
Background: Spinal Muscular Atrophy (SMA) is a genetic disorder resulting from deficiency of the survival motor neuron (SMN) protein. Emerging evidence indicates that SMA is associated with disruptions in neuroactive amin...
Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer [0.03%]
原发性ER阳性HER2阴性乳腺癌中的同源重组缺陷
Helen R Davies,Daniella Black,Anders Kvist et al.
Helen R Davies et al.
Background: Homologous recombination deficiency (HRD) originating from inactivation of genes like BRCA1/BRCA2 is a targetable abnormality common in triple-negative breast cancer (TNBC). In estrogen-receptor (ER)-positive ...
Host response biomarkers of tuberculosis recurrence and treatment failure [0.03%]
结核病复发和治疗失败的宿主反应生物标志物
Bernadette Bauer,Mohamed I M Ahmed,Olga Baranov et al.
Bernadette Bauer et al.
Background: Accurate detection of tuberculosis (TB) treatment failure and recurrence can improve disease control, but current sputum-based monitoring tools pose significant limitations. This study aimed to identify sputum...
Host proteins associated with strong neutralizing SARS-CoV-2 antibody responses in a South African cohort [0.03%]
与南非队列中较强的新冠病毒中和抗体反应相关的宿主蛋白
Afrah Khairallah,Zesuliwe Jule,Alice Piller et al.
Afrah Khairallah et al.
Background: Severe Covid-19 leads to higher neutralizing antibody levels, a key correlate of protection. However, the host proteins associated with this response have not been fully characterized. We asked which proteins ...
Rapid functional reorganization of the targeted contralesional hemisphere induced by one week of noninvasive closed-loop neurofeedback guides motor recovery in post-stroke patients with chronic motor impairment: a phase I trial [0.03%]
一周非侵入性闭环神经反馈诱导的靶向病灶对侧半球快速功能重组可指导慢性卒中患者的运动康复：Ⅰ期临床试验
Kenichi Takasaki,Seitaro Iwama,Fumio Liu et al.
Kenichi Takasaki et al.
Background: Post-stroke hemiplegia of the upper extremities continues to pose a significant therapeutic hurdle. Contralesional uncrossed corticospinal pathways (CST) are involved in the recovery processes. ...
Protein networks are influenced by maternal BMI and differentiate preterm birth types [0.03%]
蛋白质调控网络受到母体BMI的影响并可区分早产类型
Paola A Lopez Zapana,Chelsea A DeBolt,Luka Karginov et al.
Paola A Lopez Zapana et al.
Background: Preterm birth remains a leading cause of neonatal morbidity and mortality. It is classified as spontaneous, characterized by the unexpected onset of labor, or medically indicated, resulting from obstetric inte...
Short-term hormonal modulation with mifepristone does not induce oncogenic changes in the endometrium of BRCA1/2 pathogenic variant carriers [0.03%]
米非司酮短期激素调节不会诱导BRCA1/2致病性变异携带者子宫内膜致癌性变化
Martin Widschwendter,Chiara Herzog,Mohammed Fatih Rasul et al.
Martin Widschwendter et al.
Background: Progesterone receptor antagonists such as mifepristone have emerged as candidates for breast cancer prevention, particularly in high-risk populations such as BRCA1/2 pathogenic variant carriers. However, their...