VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study [0.03%]
VAL-083可有效治疗MGMT原发 unmethylated胶质母细胞瘤患者：Ⅱ期临床试验报告
Chengcheng Guo,Qunying Yang,Meiling Deng et al.
Chengcheng Guo et al.
Purpose: Unmethylated MGMT is a validated biomarker for temozolomide (TMZ) resistance and poor prognosis in glioblastoma. VAL-083 (dianhydrogalactitol; DAG) is a DNA-targeting agent that forms interstrand crosslinks at O6...
A dosimetric correlation between the bladder filling volume and its effects on radiation dose during high-dose-rate intracavitary brachytherapy in patients with cervical cancer [0.03%]
膀胱充盈体积与高剂量率腔内组织间照射时膀胱受照剂量的关系研究
Lingqin Ni,Luqi Li,De Li et al.
Lingqin Ni et al.
Background: The purpose of this study was to establish a dosimetric correlation between the bladder filling volume and its effects on the dose received by the organs at risk (OARs) (bladder, rectum, sigmoid colon and smal...
Prognostic significance of caspase 8 associated protein 2 (CASP8AP2) in childhood b cell acute lymphoblastic Leukemia [0.03%]
儿童B细胞急性淋巴细胞白血病中caspase 8相关蛋白2的预后意义
Omar Arafah,Marihame Ashraf,Ahmed Mustafa Abd Elsalam et al.
Omar Arafah et al.
Background: Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that can predict treatment response and clinical outcome. Examination of the expression...
Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer [0.03%]
.origin识别复合物1亚基作为癌症的致癌驱动基因和治疗靶点的功能
Yixuan Ding,Shiwei Cai,Jinzhou Cai et al.
Yixuan Ding et al.
ORC1 is a core protein governing DNA replication initiation and cell cycle regulation, exhibiting significant overexpression in multiple malignancies where it correlates with advanced disease stage and poor prognosis. It drives tumor progre...
Yu Xu,Yanfu Bai,Fan Yang et al.
Yu Xu et al.
Osteosarcoma (OS), the most common malignant bone tumor in adolescents, exhibits marked genetic and cellular heterogeneity, contributing to its resistance to conventional therapies. Although surgical and chemotherapeutic interventions have ...
miR-3613-5p promotes lung cancer progression by targeting and regulating XPO6 [0.03%]
miR-3613-5p通过靶向和调节XPO6促进肺癌进展
Xingya Wang,Huichao Li,Xianzhen Wu
Xingya Wang
Background: MicroRNAs (miRNAs) exert a crucial role in the progression of lung cancer (LC) and can serve as prognostic biomarkers. Aim: ...
Multiple primary cancers with prostate malignant tumor as the initial diagnosis: a case report [0.03%]
以前列腺恶性肿瘤为首诊的多原发癌一例报告
Kai Yang,Jiatong Zhou
Kai Yang
With the advancement of medical technology and improvements in living standards, the survival time of many cancer patients has been prolonged. However, a significant proportion of these patients develop multiple primary cancers (MPC), which...
Omics-enhanced nanomedicine: integrating multi-omics for precision cancer diagnosis and therapy [0.03%]
组学增强型纳米药物：整合多组学用于精准癌症诊断和治疗
Lihui Yan,Boshi Duan,Tianyou Wang et al.
Lihui Yan et al.
Brain metastasis in stage IV lung adenocarcinoma is frequently missed by symptom-based screening [0.03%]
基于症状的筛查常会遗漏四期肺腺癌的脑转移病灶
Sama I Sayin,Ella A Eklund,Moa Beischer et al.
Sama I Sayin et al.
Background: Brain metastases (BM) are a major clinical challenge in metastatic lung adenocarcinoma (LUAD), affecting up to 50% of patients during disease progression. Current guidelines do not mandate brain imaging for al...
Combining machine learning and molecular docking to unravel the molecular network of bladder cancer induced by 2-naphthylamine [0.03%]
结合机器学习和分子对接解密2-萘胺引起的膀胱癌分子网络
Ruize Qin,Cheng Li,Changxue Liu et al.
Ruize Qin et al.