The roles of non-coding RNAs (ncRNAs) in the function of leukemic stem cells (LSCs): a comprehensive review [0.03%]
非编码RNA调控白血病干细胞功能的研究进展综述
Mehran Sharifi,Shahram Nekoeian,Reza Eshraghi et al.
Mehran Sharifi et al.
All forms of leukemia, including AML, ALL, CML, and CLL, are estimated to make up 2.5% of new cancer diagnoses and 3.1% of all cancer fatalities worldwide. Leukemia is mainly propelled by LSCs that possess remarkable self-renewal and differ...
Investigating the interaction of ACKR1 and c-Myc in the breast carcinoma tumor microenvironment modulation [0.03%]
探究ACKR1与c-Myc在乳腺癌肿瘤微环境调节中的相互作用
Joyeeta Talukdar,Arnab Nayek,Gayatri Gogoi et al.
Joyeeta Talukdar et al.
This study investigates the interplay between the Atypical chemokine receptors (ACKR1)/Decoy receptor for chemokines (DARC) and key molecular markers, including CCL8, c-MYC, ALDH1, and CHEK2, in breast cancer. DARC has been implicated in va...
Integrated single-cell and bulk RNA-sequencing data reveal prognosis and therapeutic response in low-grade glioma based on hypoxia-lactylation related genes [0.03%]
整合单细胞和批量RNA测序数据基于低级别胶质瘤中缺氧-乙酰化相关的基因揭示预后和治疗反应
Hongyu Tang,Ruijie Zhang,Ying Xu et al.
Hongyu Tang et al.
Background: The prognosis of low-grade glioma (LGG) exhibits significant heterogeneity, and the optimal management strategy remains controversial. Therefore, identifying biomarkers associated with glioma prognosis is nece...
Visualizing and analyzing global knowledge maps and emerging research trends in tumor-derived exosomes using CiteSpace [0.03%]
利用CiteSpace可视化和分析肿瘤来源的外泌体全球知识图谱及研究热点和发展趋势
Ruijun Guo,Jiajun Xu,Chunxia Li et al.
Ruijun Guo et al.
Objective: Tumor-derived exosomes testing can be effective in diagnosing disease and assisting in the treatment of disease. Our study utilizes bibliometric analysis to identify research hotspots related to tumor-derived e...
Lipid homeostasis dysregulation in oral cancer drives metabolic reprogramming and offers novel diagnostic and therapeutic opportunities [0.03%]
脂质稳态失调驱动口腔癌代谢重组并提供新的诊断和治疗机会
Liang Liang,Chen Luo,Shuo Dong et al.
Liang Liang et al.
Oral cancer remains a significant global health challenge, with oral squamous cell carcinoma (OSCC) being the predominant histological type. Recent research has highlighted the critical role of metabolic reprogramming in oral carcinogenesis...
High mobility group A2 (HMGA2) protein tissue levels and its association with clinicopathological features in bladder cancer patients [0.03%]
膀胱癌患者核质蛋白HMGA2的表达及其临床病理意义
Feras Alsoufi,Almoutassem Billah Zetoune
Feras Alsoufi
Background: Bladder cancer is the most common malignancy of the urinary tract, and is characterized by a high risk of recurrence and mortality. Therefore, the research is still ongoing to determine new molecular markers t...
The instrumental role of lipids in governing the sensitivity of multiple myeloma to ferroptosis [0.03%]
脂质在调节多发性骨髓瘤对铁死亡敏感性中的作用
Ali Habib,Oliver G Best,Charlotte E Toomes et al.
Ali Habib et al.
Multiple myeloma (MM) is a malignancy characterised by the uncontrolled proliferation of clonal plasma cells, primarily within the bone marrow, and is still considered incurable. A significant proportion of patients relapse with drug-refrac...
Identification of novel cholesterol metabolism-related biomarkers for thyroid cancer to predict the prognosis, immune infiltration, and drug sensitivity [0.03%]
识别新的胆固醇代谢相关标志物以预测甲状腺癌预后、免疫浸润和药物敏感性
Xi-Xi Li,Pei Shi,Fei-Fei Wu et al.
Xi-Xi Li et al.
Background: With the sharp increase in the incidence of papillary thyroid carcinoma (PTC), the disease-specific survival rate has not improved significantly. Cholesterol metabolism plays a crucial role in tumor proliferat...
Tao Ming Sim,Wee Joo Chng,Haiyan Liu et al.
Tao Ming Sim et al.
Immune evasion is a hallmark of cancer and there is mounting evidence that the tumor microenvironment (TME) plays a role in the pathogenesis of haematologic malignancies as well as treatment resistance. Macrophages play a central role in an...
Mendelian randomization and single-cell analysis reveal causal relationships between renal clear cell carcinoma, kidney fibrosis, and inflammatory factors [0.03%]
孟德尔随机化和单细胞分析揭示了肾透明细胞癌、肾脏纤维化与炎症因子之间的因果关系
Xian Chen,Hui Wang,Qianqian Li et al.
Xian Chen et al.
Background: Renal clear cell carcinoma (RCC) is the most common type of kidney cancer, and its relationship with kidney fibrosis and inflammatory responses has attracted considerable attention. However, whether causal rel...