Emerging nanotherapeutics for HPV-associated cancers: current advances, challenges, and future directions [0.03%]
人乳头瘤病毒相关癌症纳米药物疗法的最新进展、挑战及未来方向
Ujjawal Sharma,Himanshu Shekhar,Bunty Sharma et al.
Ujjawal Sharma et al.
Human Papillomavirus or HPV are viruses belonging to the family Papillomaviridae, these have double-stranded circular DNA. HPV is among the most common sexually transmitted infections which affect over 50% of the adult population. It is als...
The role of oral microbiota in lung carcinogenesis through the oral-lung axis: a comprehensive review of mechanisms and therapeutic potential [0.03%]
口腔微生物群在通过口-肺轴的肺癌发生中的作用：机制和治疗潜力的全面综述
Mingzhu Zhou,Yan Liu,Xin Yin et al.
Mingzhu Zhou et al.
Purpose: Growing evidence highlights the crucial role of microbial communities in tumorigenesis across various organs. As the primary gateway for microbial entry into the human body, the oral cavity harbors a complex micr...
Dietary factors causally affect the risk of kidney cancer: a two-sample Mendelian randomization study [0.03%]
饮食因素会因果影响肾癌风险：两样本孟德尔随机化研究
Congcong Zhu,Tonghu Liu,Zhengyi Jiang et al.
Congcong Zhu et al.
Background: Previous observational studies have indicated potential associations between certain dietary factors and the incidence of kidney cancer. However, the causal relationship between these elements remains unknown....
PTEN defects in cancer, from gene to protein molecular causes and therapeutic targets [0.03%]
癌症中PTEN缺陷：从基因到蛋白质的分子机制及治疗靶点
Ghaith Khasarah,Darina Al Nabilsi,Odai Madani et al.
Ghaith Khasarah et al.
Recently, cancer has become a leading cause of death worldwide, prompting increased research to understand the pathways involved in cancer development and to identify solutions for its treatment. The PI3K/AKT pathway has garnered significan...
DNA methylation and transcription factor-driven immune subtypes in ovarian cancer [0.03%]
卵巢癌中表观遗传与转录因子驱动的免疫分型
Jingshu Hu,Mu Su,Zhijun Qin et al.
Jingshu Hu et al.
Ovarian cancer (OC) remains one of the deadliest gynecological malignancies. Immune checkpoint blockade (ICB) inhibitors efficacy in OC has been minimal, highlighting the need for a deeper understanding of the immune microenvironment in OC....
Xue Zhang,Hui Jin,Dan Li et al.
Xue Zhang et al.
Purpose: 5-Fluorouracil (5FU) is a primary chemotherapy for colorectal cancer (CRC), but resistance reduces its effectiveness. HADHB, important in mitochondrial fatty acid β-oxidation, is linked to tumor metabolism chang...
NTRK expression and its clinical significance in pancreatic neuroendocrine tumors [0.03%]
胰腺神经内分泌肿瘤中NTRK的表达及其临床意义
Pingping Yan,Xiaoqin Dai,Fenfen Zhang et al.
Pingping Yan et al.
Background: The neurotrophic TRK family, which includes NTRK1, 2, and 3, could be the oncogenic driving force in various cancers, when they undergo fusion mutations with other genes and form a chimeric oncoprotein. In our...
Improved brain tumor classification through DenseNet121 based transfer learning [0.03%]
基于DenseNet121的迁移学习改进大脑肿瘤分类
Mehwish Rasheed,Muhammad Arfan Jaffar,Arslan Akram et al.
Mehwish Rasheed et al.
Brain tumors have a big effect on a person's health by letting abnormal cells grow unchecked in the brain. This means that early and correct diagnosis is very important for effective treatment. Many of the current diagnostic methods are tim...
A 40-year bibliometric analysis of global research on neoadjuvant chemotherapy for oral cancer (1985-2024) [0.03%]
1985-2024年口腔癌新辅助化疗的全球研究40年文献计量分析
Xu Xiang,Ping Shi,Li Yang et al.
Xu Xiang et al.
Background: Neoadjuvant chemotherapy (NAC) has become a critical component in the treatment of oral cancer, enhancing tumor resectability and improving patient survival. This study aimed to perform a bibliometric analysis...
Tissue-specific profiling of human protein phosphatases identifies G6PC1 as a liver cancer-selective biomarker [0.03%]
组织特异性的人类蛋白磷酸酶分析鉴定出G6PC1是肝癌选择性生物标志物
Adil R Sarhan
Adil R Sarhan
Protein phosphatases are essential regulators of cellular signalling, yet their tissue-specific expression profiles and functional roles in cancer remain underexplored. This study aimed to systematically profile protein phosphatases express...