Plasma metabolites and endometrial cancer: elucidating causal associations through Mendelian randomization [0.03%]
基于孟德尔随机化的子宫内膜癌血浆代谢物研究：揭示因果关联
Songlin Xue,Kaihua Wu,Qinyuan He et al.
Songlin Xue et al.
Background: While observational studies have suggested associations between gut microbiota composition, metabolomic alterations, and endometrial cancer risk, the causal nature of these relationships remains unclear due to...
Immunogenic cell death-related macrophage gene model for prognostic prediction in glioblastoma [0.03%]
与免疫原性细胞死亡相关的巨噬细胞基因模型可预测胶质母细胞瘤的预后
Yiming Mao,Ting Li,Wenqiang Lu et al.
Yiming Mao et al.
Glioblastoma (GBM) is an extremely aggressive and diverse type of brain tumor that is associated with a poor prognosis. Immunogenic cell death (ICD) is a particular form of cellular demise that is closely linked to antineoplastic immune res...
Development of a metabolism-associated prognostic risk model based on immune landscape stratification in prostate cancer [0.03%]
基于免疫分层的前列腺癌代谢相关预后风险模型的建立
Yuanting Liu,Yixiao Shi,Yujie Cao et al.
Yuanting Liu et al.
Background: Metabolic reprogramming and immune landscape remodeling are hallmarks of prostate cancer (PCa) progression and therapy resistance. However, the interplay between tumor metabolism, immune infiltration, and prog...
Potential of circulating miR-6875 and miR-1307 as non-invasive diagnostic biomarkers for pancreatic cancer [0.03%]
循环miR-6875和miR-1307作为胰腺癌非侵入性诊断生物标志物的潜力
Vinit Sharma,Ankita Semwal,Shivangani Lohani et al.
Vinit Sharma et al.
Aim: Pancreatic cancer (PC) is marked by high mortality and resistance to conventional therapies, largely due to a dense desmoplastic stroma that promotes drug resistance and metastasis. This highlights the need for speci...
Regulation of major histocompatibility complex class-I (MHC-I) gene methylation using DNA methyltransferase inhibitor and PD-L1 inhibitor in triple negative breast cancer [0.03%]
DNA甲基转移酶抑制剂和PD-L1抑制剂调控三阴性乳腺癌中主要组织相容性复合体I类(MHC-I)基因的甲基化研究
Young Ju Jeong,Na-Rang Lee,Hoon Kyu Oh
Young Ju Jeong
Big data analysis reveals miR-874 as a suppressor and therapeutic target in the progression from endometriosis to ovarian cancer [0.03%]
基于大数据分析发现miR-874作为子宫内膜异位症进展为卵巢癌的抑制因子及治疗靶点
Peihong Lin,Ling Wu,Xuedan Lai et al.
Peihong Lin et al.
Identification of immunosuppressive CD4+ T-cell subtype and construction of prognostic model for hepatocellular carcinoma [0.03%]
肝细胞癌中免疫抑制CD4+T细胞亚型的鉴定及其预后模型的建立
Chuxuan Wang,Lianchi Li,Yingrui Lou et al.
Chuxuan Wang et al.
Background: CD4+ T cells, as critical mediators of immune regulation, have not been fully elucidated in their role in hepatocellular carcinoma (HCC) immune evasion. ...
Decoding the functional roles of circular RNAs linked to NF-κB pathway in carcinogenesis [0.03%]
解码circRNA通过NF-κB通路在肿瘤发生发展中的功能作用
Wei Wang,Kang Zheng,Zhi Feng et al.
Wei Wang et al.
CircRNAs, a class of covalently closed noncoding RNAs, have emerged as pivotal regulators of the NF-κB signaling pathway in carcinogenesis. Accumulating evidence demonstrates that the circRNA/NF-κB axis regulates key cancer-related proces...
Integrated single-cell transcriptomics and Mendelian randomization identify neutrophil-associated biomarker genes in colorectal cancer [0.03%]
整合单细胞转录组和孟德尔随机化识别结直肠癌中与中性粒细胞相关的生物标志物基因
Hongting Yan,Yingjie Li,Bing Yang et al.
Hongting Yan et al.
Background: Colorectal cancer (CRC) is a prevalent digestive malignancy imposing significant economic burdens worldwide. However, the role and underlying mechanisms of neutrophil infiltration in CRC remain unclear. We the...
Single-cell RNA-seq reveals gene expression heterogeneity in NSCLC and its link to the immune microenvironment [0.03%]
单细胞RNA测序揭示了非小细胞肺癌的转录异质性及其与免疫微环境的关系
Jinzhuo Ren,Hua Zhang,Haiyong Wu
Jinzhuo Ren
Background: Non-small cell lung cancer (NSCLC) is one of the leading cause of cancer-associated mortality globally. Its tumor microenvironment consists of various types of cells, which have a great impact on patient respo...