Integrative bioinformatics analysis and elastic network modeling elucidate the role of cellular senescence in meningioma recurrence [0.03%]
整合生物信息学分析和弹性网络建模阐明细胞衰老在脑膜瘤复发中的作用
Jian-Huang Huang,Yao Chen,Yuan-Bao Kang et al.
Jian-Huang Huang et al.
Background: Cellular senescence is intimately tied to tumorigenesis and progression, yet its exploration in meningiomas remains inadequate. In this study, we aim to unravel the role of cellular senescence-associated genes...
Exploring the genetic determinants of the oral microbiome's role in gastrointestinal cancer risk: Mendelian randomization and genetic correlation analysis in an East Asian population [0.03%]
东亚人群口腔微生物组在胃肠道癌症风险作用的遗传决定因素研究：孟德尔随机化及遗传相关性分析
Wei Jin,ZongYao Zhang,Hang Zhang et al.
Wei Jin et al.
Background: The human oral microbiome plays a significant role in systemic health, including potential links to digestive tract cancers. However, few studies have examined the causal relationship between the oral microbio...
Unveiling the oncogenic functions of lncRNA PSMG3-AS1: a review of its biological roles in cancer [0.03%]
长链非编码RNA PSMG3-AS1的致癌功能初探——癌生物学作用研究进展回顾式评述
Hui Zhang,Xin Wang
Hui Zhang
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of various biological processes, including gene expression, cell differentiation, and response to external stimuli. Among them, PSMG3-AS1 has gained attention due to its invo...
Identification of immunoheterogeneous key prognostic protein ZC3H12D in OSCC and analysis of prognostic models and drug resistance [0.03%]
口腔癌免疫异质性关键预后蛋白ZC3H12D的鉴定及预后模型和药物敏感性分析
Qianqian Wang,Shuai Qi,Jing He et al.
Qianqian Wang et al.
Background: We constructed a nomogram model utilizing key clinical and molecular biological variables to predict the 1-year, 3-year, and 5-year survival probabilities for patients with oral squamous cell carcinoma (OSCC)....
CLEC11A as a potential biomarker for prognosis and response to immunotherapy in colon adenocarcinoma [0.03%]
CLEC11A作为结肠腺癌预后和免疫治疗反应的潜在生物标志物
Yuyang Gu,Yanjun Li,Tingting Qian et al.
Yuyang Gu et al.
LncRNA B4GALT 1-AS1/miR-144-3p axis suppresses cytotoxicity of CD8+ T cells in lung adenocarcinoma by modulating PD-L1 expression [0.03%]
长链非编码RNA B4GALT1-AS1/miR-144-3p轴通过调节PD-L1表达抑制肺腺癌中CD8+T细胞的细胞毒性
Lifei Huang,Jiadong Wu,Yahong Sun et al.
Lifei Huang et al.
Background: For lung adenocarcinoma (LUAD), which has the highest mortality rate among cancers, the current known immunotherapy has only achieved limited results. This article aimed to clarify the novel immune escape mech...
Computational prediction of diagnostic biomarker candidates and prognostic gene signature from DNA replication-related genes in breast cancer [0.03%]
基于DNA复制相关基因的乳腺癌诊断生物标志物及预后基因标记物的计算预测研究
Ceren Sucularli
Ceren Sucularli
Background: Given the role of DNA replication in tumorigenesis, identifying diagnostic and prognostic biomarkers of this process using machine learning approaches may reveal new therapeutic targets and improve prognostic ...
EGFL9 regulates the growth and metastasis of hepatocellular carcinoma through EGFR/PI3K/AKT signaling pathway and amino acid modulation [0.03%]
EGFL9通过EGFR/PI3K/AKT信号通路和氨基酸调节调控肝细胞癌的生长和转移
Ziye Li,Jingyang Feng,Longcheng Zhao et al.
Ziye Li et al.
Background: Previous research has highlighted the roles of epidermal growth factor-like (EGFL) 7 and EGFL8 in hepatocellular carcinoma (HCC), while EGFL9 has been implicated in other cancers such as breast cancer. Despite...
Antibody-drug conjugates in triple-negative breast cancer (2010-2024): a bibliometric analysis of global trends and clinical translation [0.03%]
抗体偶联药物在三阴性乳腺癌（2010-2024）：全球趋势和临床转化的文献计量分析
Xin-Yu Li,Shan-Qi Li,Si-Lu Xiang et al.
Xin-Yu Li et al.
Purpose: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor outcomes. Antibody-drug conjugates (ADCs), linking monoclonal antibodies to cytotoxic payloads, show promise as targeted therapies. Despite ...
Marzieh Shokoohi,Mobin Ghaderi,Milad Mokarami et al.
Marzieh Shokoohi et al.