Multi-omics analysis of ILF2 reveals its prognostic value and functional roles across pan-cancer [0.03%]
泛癌分析ILF2的多组学研究及其预后和功能价值评估
Huan Xiong,Zewei Chen,Junjie Xu et al.
Huan Xiong et al.
Background: The growing incidence and high mortality of malignant tumors render them a persistent challenge to global health. Interleukin enhancer-binding factor 2 (ILF2), a nuclear protein involved in gene regulation, ha...
Prevalence of GLUT1 overexpression in human cancers a systematic review and meta analysis [0.03%]
人癌症中GLUT1过度表达的流行率：系统回顾和meta分析
Quan Yuan,Hongzhi Liu,Canxu Song et al.
Quan Yuan et al.
Background: The clinical significance of glucose transporter 1 (GLUT1) expression in cancers remains controversial due to inconsistent findings. This meta-analysis systematically evaluates the association between GLUT1 ov...
Genetic risk and clinical implications of BRCA1 and BRCA2 mutations in Turkish triple-negative breast cancer patients [0.03%]
土耳其三阴性乳腺癌患者的BRCA1和BRCA2突变的遗传风险及临床意义
Betul Celik Demirbas,Seda Kilic Erciyas,Ozge Sukruoglu Erdogan et al.
Betul Celik Demirbas et al.
Background: Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Genetic mutations, particularly in BRCA1 and BR...
Mendelian randomization analysis reveals no causal association between non-alcoholic fatty liver disease and hepatocellular carcinoma: implications for lipid metabolomics and shared pathophysiological mechanisms [0.03%]
门德尔随机对照分析未发现非酒精性脂肪肝与肝细胞癌存在因果关联：脂质代谢组学和共同病理生理机制的启示
Yingying Wei,Junlian Li
Yingying Wei
Background: Non-alcoholic fatty liver disease (NAFLD) has been increasingly associated with hepatocellular carcinoma (HCC) risk in observational studies, yet the causal nature of this relationship and its impact on system...
Exploring metabolic pathways in gastrointestinal cancer: new evidence of causality [0.03%]
探讨胃肠癌症中的代谢途径：因果关系的新证据
Zhiguo Wang,Chen Wang,Xiangyu Gao
Zhiguo Wang
Background: In recent years, the development of metabolomics has provided new opportunities to explore the associations between hundreds of metabolites and cancer risk, and it is increasingly being utilized in cancer rese...
Benign prostatic hyperplasia and risk of urological cancers: a prospective cohort study based on the UK biobank [0.03%]
基于英国生物银行的前瞻性队列研究：良性前列腺增生与泌尿系统肿瘤发病风险的关系
Jinjing Guo,Liang Zhou,Jiaming He et al.
Jinjing Guo et al.
Background: Benign prostatic hyperplasia (BPH) is considered a risk factor for certain urological cancers; however, current evidence remains ambiguous. This study aimed to assess the relationship between BPH and risk of u...
Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma [0.03%]
肺癌腺癌代谢基因甲基化表达和蛋白水平的孟德尔随机化分析
Qing Wang,Gang Liu,Jun Zhang et al.
Qing Wang et al.
Background: Metabolic reprogramming is a hallmark of cancer development, including in lung adenocarcinoma (LUAD). This study aimed to explore the relationships between metabolic gene methylation, expression, and protein l...
Firmicutes in gut microbiota: hormonal influence on breast cancer in obese individuals [0.03%]
肥胖个体中肠道菌群 Firmicutes：激素对乳腺癌的影响
Jiale Chen,Zicheng Zhang,Manqi Ma et al.
Jiale Chen et al.
Breast cancer (BC) is among the leading causes of death in women. The risk factors of BC are various, among which obesity has been proved to be closely related to the incidence and progression of BC, especially in postmenopausal women. Obes...
An integrative bioinformatic and Mendelian randomization study exploring the role of polyunsaturated fatty acid metabolism in laryngeal cancer [0.03%]
整合生物信息学和孟德尔随机化研究探讨多不饱和脂肪酸代谢在喉癌中的作用
Lina Peng,Haibin Ma,Longchao Qin et al.
Lina Peng et al.
Objective: This study aimed to explore potential associations between polyunsaturated fatty acid (PUFA) metabolism and laryngeal cancer (LC) using a combination of Mendelian randomization (MR) and integrative bioinformati...
Multilayered insights into the full spectrum of diffuse gliomas: a novel prognostic evaluation model [0.03%]
弥漫性胶质瘤的多层全景洞察：新型预后评估模型
Xu Cao,Mingfan Liu,Dongmei Zou et al.
Xu Cao et al.
Background: The intrinsic heterogeneity and invasiveness of diffuse gliomas complicate accurate prognosis. Existing approaches are largely constrained by subtype specificity or limited analytical dimensions. To address th...