DNMT3A-R882 mutation promotes acute myeloid leukemia progression by recruiting E2H2 to inhibit circKCNQ5 methylation [0.03%]
DNMT3A-R882突变通过募集E2F2抑制circKCNQ5甲基化来促进急性髓系白血病的进展
Yijian Chen,Xiaodan Zhu,Chuanming Lin et al.
Yijian Chen et al.
Background: Patients with acute myeloid leukemia (AML) harboring the DNMT3A-R882 mutation (DR882MUT) are often more difficult to treat and more likely to relapse. However, whether DR882MUT modulates AML progression via ci...
The causal relationship between platelet indices and liver cancer: a bidirectional two-sample Mendelian randomization study [0.03%]
血小板指标与肝癌的因果关系：双向两样本孟德尔随机化研究
Xin He,Yuzhe Zhang,Zhengsheng Yi et al.
Xin He et al.
Background: Platelet indices are non-invasive biomarkers used to assess disease status. Observational studies have shown that platelet indices are related to liver cancer. However, the specific relationship between the tw...
Identification of prognostic biomarkers associated with T and melanoma cell subpopulations in melanoma through integrating machine learning and multiomics [0.03%]
通过整合机器学习和多组学识别与黑色素瘤中T细胞和黑色素瘤亚群相关的预后生物标志物
Huiwen Zheng,Chen Shen,Liming Ma et al.
Huiwen Zheng et al.
Background: Melanoma is a highly lethal cancer with a poor prognosis. T-cells and melanoma cells play crucial role in shaping the tumor microenvironment, yet their role and impact on prognosis in melanoma is still unclear...
Integrating single-cell and bulk RNA sequencing data establishes a cuproptosis-related gene predictive signature in breast cancer [0.03%]
单细胞和批量RNA测序数据的整合建立了乳腺癌中与铜死亡相关的基因预测标志物
Rongrong Peng,Yu Li,Bo Xu
Rongrong Peng
Breast cancer (BRCA) remains the most common malignancy and the leading cause of cancer-related death among women worldwide. Recent studies have highlighted dysregulated copper homeostasis as a contributor to tumorigenesis, with cuproptosis...
Mechanistic evaluation of hyperoside against non-small cell lung cancer: a combined approach of network pharmacology and in vitro experimental validation [0.03%]
基于网络药理学和体外实验验证的芸香苷抗非小细胞肺癌的作用机制研究
Shuang Xu,Yaping Zou,Guangwen Luo et al.
Shuang Xu et al.
Background: Hyperoside (Hyp) exerts considerable inhibitory effects on non-small-cell lung cancer (NSCLC) cells. However, the underlying molecular mechanisms have not been fully elucidated. We aimed to explore the molecul...
Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer [0.03%]
泛癌症分析揭示AOC3可作为结直肠癌潜在的治疗生物标志物
Guanlong Wang,Lidan Zhu,Ling Lu et al.
Guanlong Wang et al.
Amine oxidase copper containing 3 (AOC3) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function. However, the potential function of AOC3 in cancer had not ...
Mendelian randomization analysis of druggable gene expression in liver cancer risk and autoimmune hepatitis [0.03%]
药物靶点基因在肝癌和自身免疫性肝炎中的孟德尔随机化分析
Mingming Lian,Jun Yao
Mingming Lian
Background: Liver cancer remains one of the most prevalent and lethal malignancies worldwide, while autoimmune hepatitis is an immune-mediated inflammatory liver disease characterized by circulating autoantibodies and dis...
Global research trends in CAR-T cell therapy for glioblastoma: a bibliometric and visualized analysis [0.03%]
全球CAR-T细胞治疗胶质母细胞瘤研究趋势的计量学和可视化分析
Jian Li,Lichun Lu,Yu Duan et al.
Jian Li et al.
Background: Glioblastoma (GBM) is the most aggressive and lethal primary malignant brain tumor in adults, characterized by extensive heterogeneity and a profoundly immunosuppressive microenvironment. Despite advances in s...
SMPD2 affects the prognosis of cancer patients by mediating lipid metabolism and the immune microenvironment [0.03%]
SMPD2通过介导脂质代谢和免疫微环境影响癌症患者的预后
Qing-Yan Li,Jia-Ming Huang,Xiang Yuan et al.
Qing-Yan Li et al.
The gene Sphingomyelin phosphodiesterase 2 (SMPD2), a member of the SMPD family, plays crucial roles in cell cycle progression and cell proliferation. However, the pathogenic implications of SMPD2 across various cancers remain poorly unders...
Single-cell RNA sequencing reveals NFATc1-mediated regulatory mechanisms of vascular smooth muscle cell osteogenic transformation in the osteosarcoma microenvironment [0.03%]
单细胞RNA测序揭示NFATc1介导的血管平滑肌细胞向骨肉瘤微环境中的成骨转化的调控机制
Xuejiao Yi,Shilin Fu,Chunliang Zhang et al.
Xuejiao Yi et al.
Background: Osteosarcoma is the most common primary malignant tumor of bone and occurs predominantly in children and adolescents during periods of accelerated skeletal growth. Within the tumor microenvironment (TME), vasc...