Longitudinal identification of sentinel symptoms across frailty dimensions in lung cancer patients undergoing radiotherapy [0.03%]
放射治疗的肺癌患者在脆弱性维度中随访监测预警症状
Jiang Zhang,Xijuan Zhao,Song Li et al.
Jiang Zhang et al.
Purpose: This study aimed to identify sentinel symptoms related to frailty in patients with lung cancer undergoing radiotherapy (RT) across the physical, psychological, and social domains at different treatment stages. Th...
A GIMAP family signature for prognostic prediction and immune characterization in hepatocellular carcinoma patients [0.03%]
GIMAP家族签名在肝细胞癌患者预后预测及免疫表型鉴定中的作用
Jianlin Lv,Linlin Liu,Meng Xia et al.
Jianlin Lv et al.
Background: GTPase, IMAP family genes (GIMAPFGs) are extensively used for diagnosis and treatment in cancer, their prognostic significance and therapeutic potential in hepatocellular carcinoma (HCC) remain insufficiently ...
Precision theranostics in oncology: integrating antibody-drug conjugates, radioimmunotherapy, and immuno‑PET for adaptive cancer care [0.03%]
精准肿瘤诊疗：抗体-药物偶联物、放射免疫治疗和免疫-PET在个性化癌症诊治中的整合应用
Jingyi Wang,Qian Zhang,Yang Cao et al.
Jingyi Wang et al.
The century-old vision of a "magic bullet" in oncology is being realized through the paradigm of precision theranostics, which formally integrates targeted delivery, cytotoxic action, and non-invasive imaging into a unified clinical feedbac...
Identification of biomarkers associated with diagnosis of gastroesophageal junction adenocarcinoma and their correlation with immune infiltration [0.03%]
胃食管交界处腺癌诊断相关生物标志物的识别及与免疫浸润的相关性研究
Jianfu Zhu,Aimin He,Yujing Zhang et al.
Jianfu Zhu et al.
Background: Gastroesophageal junction adenocarcinoma (GEJAC) is a highly lethal malignancy, and its molecular mechanisms are still not well understood. Reliable biomarkers for early diagnosis and immunotherapy are urgentl...
NAT10 drives ovarian cancer progression via NLRP3 mRNA ac4C modification [0.03%]
NAT10通过NLRP3 mRNA的ac4C修饰促进卵巢癌进展
Yu Liu,Yu Yang,Chun-Chun Wang et al.
Yu Liu et al.
Background: Ovarian cancer (OV) is characterized by uncontrolled malignant proliferation of ovarian tissue. N-acetyltransferase 10(NAT10) enhances mRNA stability through N4-acetylcytidine (ac4C) modification. ...
Early chemotherapy symptom clusters predict quality of life and treatment adherence in lung cancer patients [0.03%]
早期化疗症状群可预测肺癌患者生活质量及治疗顺应性
Limei Zhao,Ling Yu,Suping Wang et al.
Limei Zhao et al.
Purpose: To identify symptom clusters in lung cancer (LC) patients during the early chemotherapy interval and evaluate their predictive value for quality of life (QoL) and treatment adherence. ...
Combining single cell and bulk transcriptomics with Mendelian randomization identifies gut microbiota related prognostic genes and mechanisms in thyroid cancer [0.03%]
结合单细胞和批量转录组与孟德尔随机化识别甲状腺癌相关预后基因及机制
Xiangyu Wang,Bing Wang,Shimei Ding et al.
Xiangyu Wang et al.
Background: Imbalance in gut microbiota (GM) may play a role in the development of thyroid cancer (TC), but the specific mechanisms remain unclear. This study aimed to identify prognostic genes associated with both TC and...
Ying Tao,Chunhan Liu,Shenzhang Zhang et al.
Ying Tao et al.
Schwannomas are benign tumors arising from Schwann cells, which are present in all peripheral nerves. However, the olfactory nerve lacks typical Schwann cell ensheathment, making the development of true schwannomas in this region highly unl...
Integrating machine learning and single-cell sequencing to reveal the role of kinase-related genes in subtype classification and prognostic significance of lung squamous cell carcinoma [0.03%]
结合机器学习和单细胞测序揭示激酶相关基因在肺鳞癌分型及预后中的作用
Yan Lv,Zhihan Xiao,Xu Zhan et al.
Yan Lv et al.
Background: Lung squamous cell carcinoma (LUSC) exhibits poor prognosis and a highly complex tumor immune microenvironment (TIME), creating an urgent clinical need for novel biomarkers to guide personalized treatment. Alt...
Identification and validation of a Golgi apparatus related gene signature for prognosis prediction and immune microenvironment profiling in colorectal cancer [0.03%]
结肠癌中与高尔基体相关的基因特征的识别、验证及其预后预测和免疫微环境分析
Shuaiyi Wu
Shuaiyi Wu
Background: Colorectal cancer (CRC) is a leading cause of cancer mortality. The Golgi apparatus (GA) mediates protein glycosylation and secretion, and its dysfunction is implicated in cancer invasion and immune evasion [1...