Isoquercitrin triggers the ferroptosis of ovarian cancer via SLC7A11-dependent manner to repress its tumorigenesis [0.03%]
异檞皮素通过SLC7A11依赖方式诱导卵巢癌细胞铁死亡以抑制其恶性表型
Xiaolong Zhang,Youzhen Luo,Qiaoling Gao et al.
Xiaolong Zhang et al.
TERT links telomere length to cancer risk by integrating genomic instability and immune modulation [0.03%]
端粒酶逆转录酶通过整合基因组不稳定性与免疫调控连接端粒长度和癌症风险
Jingwei Zhao,Jiayun Zhu,Kangle Zhu et al.
Jingwei Zhao et al.
Background: Telomere homeostasis serves as a key regulatory mechanism linking aging and cancer. While telomere attrition imposes a proliferative barrier by inducing cellular senescence, abnormal telomere elongation circum...
Prognostic factors and nomogram for intracranial malignant meningeal sarcomatosis: a population-based retrospective surveillance, epidemiology, and end results database analysis [0.03%]
基于人群的SEER数据库分析的颅内恶性脑膜肉瘤预后因素及预测模型
Siyuan Yang,Xiaoyu Ji,Tong Wang et al.
Siyuan Yang et al.
Background: Intracranial Meningeal Sarcomatosis (MS) is a rare neoplasm of the central nervous system (CNS), characterized by diagnostic challenges and a poor prognosis. This study aimed to utilize Surveillance, Epidemiol...
Pan-cancer multi-omics profiling reveals ubiquitin D as a novel biomarker for diagnosis, immune microenvironment remodeling and prognostic prediction [0.03%]
泛癌多组学分析揭示了泛素D是一种新的诊断生物标志物，在免疫微环境重塑和预后预测方面具有潜在作用
Yinxia Su,Yong Wang,Fei Liu et al.
Yinxia Su et al.
Ubiquitin D (UBD), a key member of the ubiquitin-like modifier (UBL) family, plays a critical role in targeting proteins for proteasomal degradation. Current research indicates that UBD is frequently overexpressed in various malignancies, w...
Effect of body mass index on postoperative lymphedema after breast cancer: a systematic review and meta-analysis [0.03%]
体质指数对乳腺癌术后淋巴水肿影响的系统评价和meta分析
Weiwei Zhang,Zhilin Liu,Jinming Li et al.
Weiwei Zhang et al.
Background: Upper extremity lymphedema, a major complication post-breast cancer surgery, severely impacts quality of life. While body mass index (BMI) is suggested as a risk factor for postoperative breast cancer-related ...
Exploring drug repurposing for PAK2 inhibition: a systematic virtual screening of FDA-approved drugs against cancer [0.03%]
抗癌PAK2抑制剂药物再利用的系统虚拟筛选研究
Shadma Wahab,Abdulrhman Alsayari,Taghreed A Majrashi et al.
Shadma Wahab et al.
The p21-activated kinase 2 (PAK2), a serine/threonine kinase, directly participates in the regulation of various cellular signaling pathways and plays a critical role in cell motility, survival, and proliferation. Due to its crucial role in...
Predictive factors of pathologic good response after neoadjuvant chemoradiotherapy for rectal cancer [0.03%]
新辅助放化疗后直肠癌病理性良好反应的预测因素分析
Yi-En Lin,Tung-Hao Chang,Tsai-Wei Chou et al.
Yi-En Lin et al.
Background: For patients with T3/T4N0, T(any)N+, or locally unresectable rectal cancer, the treatment approach involves preoperative chemoradiation (CRT) followed by radical surgical resection. Our objective was to identi...
Deciphering key chemotherapeutic drug targets within tyrosine metabolism for breast cancer and advancing a wide-ranging diagnostic strategy [0.03%]
揭秘乳腺癌酪氨酸代谢关键化疗药物靶点及推进广泛诊断策略
Dan Lu,Jun Yang,Reng-Min Wu et al.
Dan Lu et al.
Background: The impact of tyrosine metabolism on the early diagnosis and treatment of breast cancer remains unclear. This underlines importance of exploring its mechanisms. ...
Identification and prognostic significance of Ki-67-related genes in triple negative breast cancer [0.03%]
三阴性乳腺癌中Ki-67相关基因的鉴定及其预后价值
Wenhan Li,Dan Chen,Jianhui Li
Wenhan Li
Objective: This study was aimed to screen and validate key genes associated with Ki-67 expression and evaluate their prognostic significance in patients with triple-negative breast cancer (TNBC). ...
Cell division cycle 25 C (CDC25C) mediates cell-cycle progression and immune evasion in glioma [0.03%]
细胞分裂周期蛋白25C介导胶质瘤的细胞周期进程和免疫逃逸
Anqi Qiao,QiuYue Zhang,Jiakai He et al.
Anqi Qiao et al.
Background: Gliomas are highly aggressive brain tumors with poor outcomes. CDC25C, a phosphatase that activates the CDK1-Cyclin B1 complex at the G₂/M checkpoint, is implicated in several cancers but its role in glioma p...