Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study [0.03%]
遗传学随机研究解读溶酶体蛋白酶在消化系统癌症中的作用
Beian Guo,Zhiyi Zhou,Wanzhe Liao et al.
Beian Guo et al.
Digestive system cancers (DSCs) present a global health challenge. This study aimed to investigate the causal relationships between cathepsins and DSCs using Mendelian Randomization (MR) analysis. Single Nucleotide Polymorphisms (SNPs) asso...
Voxel-wise analysis of brain metastasis predilection sites in breast cancer by clinical features [0.03%]
基于临床特征的乳腺癌脑转移好发部位的体素分析
Hairong Wang,Hongyu Chen,Haoqun Xie et al.
Hairong Wang et al.
Purpose: Brain metastases (BMs) occur in 15-30% of breast cancer patients, particularly in HER2-positive and triple-negative(TN) subtypes, and signify poor prognosis. This study aimed to identify vulnerable BM locations t...
Mapping research hotspots and trends in hepatocellular carcinoma nanomedicine: a bibliometric analysis [0.03%]
肝细胞癌纳米医学研究热点及趋势的文献计量学分析
Lu Yang,Lei Yu,Qiang Zhou et al.
Lu Yang et al.
Hepatocellular carcinoma (HCC) is a prevalent cancer globally with a poor prognosis. Nanomedicine applications are expected to enhance early detection, improve cytotoxic drug utilization, and improve HCC prognosis. This study aims to conduc...
Comparative evaluation of CD34 immunohistochemistry and hematoxylin and eosin staining for detection of lymphovascular emboli in oral squamous cell carcinoma: a retrospective cross-sectional study in a developing country [0.03%]
CD34免疫组化与苏木精-伊红染色检测口腔鳞癌淋巴管血管癌栓的比较分析：发展中国家的回顾性横断面研究
Kajal Hatgaonkar,Anand Hatgaonkar,Pratibha Dawande et al.
Kajal Hatgaonkar et al.
Objectives: The primary objective was to evaluate and compare the sensitivity and specificity of CD34 immunohistochemistry (IHC) versus conventional hematoxylin and eosin (H&E) staining in detecting lymphovascular emboli ...
Driver gene-specific prevalence and incidence of brain metastases in non-small cell lung cancer: a meta-analysis encompassing all disease stages [0.03%]
驱动基因非小细胞肺癌脑转移的患病率和发病率：涵盖所有疾病期的荟萃分析
Yu Zhang,Yuxin Wen,Peiyang Fan et al.
Yu Zhang et al.
Background: Brain metastases (BM) in non-small cell lung cancer (NSCLC) are associated with a poor prognosis. Identifying relevant genomic alterations can facilitate the targeting of therapies. We conducted a systematic r...
CDCA5 knockdown potentiates olaparib sensitivity in BRCA1-mutated ovarian cancer through autophagy activation [0.03%]
CDCA5敲低通过激活自噬增强卵巢癌中olaparib对BRCA1突变的敏感性
Wenzong Wu,Huan Wu,Yuqing Song et al.
Wenzong Wu et al.
Background: BRCA1-mutated ovarian cancer poses substantial therapeutic hurdles due to its poor prognosis and resistance to traditional therapies. Although acquired resistance is still a significant obstacle, PARP inhibito...
Mendelian randomization analyses support causal relationships between unswitched memory B cells and lung squamous cell carcinoma [0.03%]
门德尔随机化分析支持未转换记忆B细胞与肺鳞状细胞癌之间的因果关系
Hong-Jun Li,Chun-Yu Lin,Dai-Zheng Huang et al.
Hong-Jun Li et al.
Background: The interaction between immune cells and cancer has been extensively researched. However, little is known about the relationship between B Cells and lung squamous cell carcinoma (LUSC). ...
Identification of KIF14 as a ferroptosis biomarker for predicting the prognosis and immunotherapy efficacy of bladder cancer [0.03%]
鉴定KIF14作为预测膀胱癌预后和免疫治疗效果的铁死亡生物标志物
Xiaocheng Ma,Changyi Quan
Xiaocheng Ma
Background: Ferroptosis, a recently recognized form of regulated cell death, plays a prominent role in anti-tumor immunity. However, the potential functions of ferroptosis-related regulators in the prognosis, immune check...
Lactylation-related gene signatures for prognosis and treatment response prediction in radiation-resistant non-small cell lung cancer [0.03%]
辐射抵抗非小细胞肺癌预后及治疗反应相关的乳酰化基因特征预测
Xiangdi Yang,Guanjun Li,Rong Jiang et al.
Xiangdi Yang et al.
Background: Lactylation, as a novel type of post-translational protein modification, is closely associated with key processes such as cellular metabolism, the tumor immune microenvironment, tumor proliferation, and metast...
Yumin Liang,Yingjie Shao,Wendong Gu
Yumin Liang
Tumor therapy resistance presents a significant challenge in cancer treatment. Although substantial strides have been made in the domains of early diagnosis and therapeutic interventions within contemporary medicine, a considerable proporti...