Gene-edited hematopoietic stem cells for leukemia and lymphoma treatment: a systematic review of preclinical and translational evidence [0.03%]
基因编辑造血干细胞治疗白血病和淋巴瘤的临床前及转化证据系统评价
Hassan Nourmohammadi,Mashallah Babashahi,Mohammad Panji et al.
Hassan Nourmohammadi et al.
Background: Hematopoietic stem cells (HSCs) are pivotal in regenerating the blood and immune systems and have been widely used in treating hematologic malignancies like leukemia and lymphoma. Advances in gene-editing tech...
Comprehensive bioinformatics evaluation uncovers the possible oncogenic contribution of acrylamide to endometrial cancer [0.03%]
全面生物信息学评估揭示丙烯酰胺可能对子宫内膜癌的致癌贡献
Yiting Zou,Shan Lu,Shiqiang Han et al.
Yiting Zou et al.
Background: Endometrial cancer (EC) is a prevalent gynecological malignancy with increasing incidence worldwide. Despite advancements in treatment, challenges such as tumor recurrence and chemoresistance persist. Acrylami...
Identification of key biomarkers and immune microenvironment features in gliomas based on single-cell analysis combined with bioinformatics [0.03%]
基于单细胞分析联合生物信息学的胶质瘤关键生物标志物及免疫微环境特征识别
Yang Zhang,Lisha Liu,Chao Peng et al.
Yang Zhang et al.
Gliomas are highly invasive and heterogeneous tumors in the central nervous system (CNS), characterized by poor prognosis and significant therapeutic challenges. The comprehensive understanding of their molecular mechanisms remains a critic...
Expression of FoxP3 in oral squamous cell carcinoma and its biological significance [0.03%]
FoxP3在口腔鳞状细胞癌中的表达及其生物学意义
Lina Jiang,Yangxiao Zhang,Chenchen Zhu et al.
Lina Jiang et al.
Introduction and objective: Oral squamous cell carcinoma (OSCC) is a highly malignant tumor that is prone to lymph node metastasis and distant metastasis. FoxP3 is a specific surface marker of regulatory T cells, and its ...
Deep learning-based survival prediction model for adult diffuse low-grade glioma: a multi-cohort validation study [0.03%]
基于深度学习的成人弥漫性低级别胶质瘤生存预测模型的多队列验证研究
Pengfei Xu,Wenxin Liu,Haibo Su et al.
Pengfei Xu et al.
Background: Accurate prognostication in adult diffuse low-grade glioma (DLGG) patients remains challenging due to the complex interplay of clinical and molecular factors. This study aimed to develop and validate a deep le...
Uche Samuel Ndidi,Israel Ogwuche Ogra,Emohchonne Utos Jonathan et al.
Uche Samuel Ndidi et al.
Cancer is one of the most pressing global health challenges. Drug repurposing is regarded as the most effective strategy in developing drug candidates by using therapeutic characteristics of well-known drugs. A bibliometric analysis was con...
Genetic and epigenetic contribution to tamoxifen resistance in breast cancer, concepts to drive therapeutic strategies [0.03%]
基因和表观遗传因素导致乳腺癌患者他莫昔芬耐药的机制及其对治疗策略的影响
Rosa Jahangiri
Rosa Jahangiri
Patients with estrogen receptor-positive (ER+) breast carcinoma often receive tamoxifen as an anti-estrogen therapy; however, a significant number still experience disease recurrence during treatment. The molecular mechanisms behind tamoxif...
Prognostic analysis and immunotherapy prediction based on key receptor-ligand pairs of bladder cancer [0.03%]
基于关键受体-配体对的膀胱癌预后分析及免疫治疗反应预测研究
Yuhang Wang,Tailai Zhou,Chen Hu et al.
Yuhang Wang et al.
Background: Bladder cancer is a prevalent malignant tumor in the urinary system, ranking tenth among malignant tumors globally. Currently, the primary treatment methods include surgery, chemotherapy, immunotherapy, and em...
Yi Huang,Shenbao Shi,Qiuchan Yan et al.
Yi Huang et al.
Background: Glioma was a kind of malignant tumor associated with high mortality and recurrence. Therefore, it was urgent to establish effective prognostic models to guide clinical treatment in glioma. Protein lactylation ...
Integrative multi-omics analysis identifies AEBP1 and EFEMP2 as key regulators of immune heterogeneity and therapeutic response in glioblastoma [0.03%]
整合多组学分析识别出AEBP1和EFEMP2是免疫异质性及胶质母细胞瘤治疗反应的关键调节因子
Yi Yin,Xingyu Fu,Shuhua Gong et al.
Yi Yin et al.
Objective: Glioblastoma (GBM) is a highly aggressive brain tumor with complex immune microenvironment and molecular heterogeneity. This study aimed to characterize immune infiltration patterns and identify prognostic biom...