Elucidating biomarkers of carcinogenesis in ulcerative colitis: insight from Mendelian randomization and transcriptomics [0.03%]
溃疡性结肠炎致癌标志物的阐明：来自孟德尔随机化和转录组学的见解
Xiang Xiao,Xuanyu Wu,Tian Liu et al.
Xiang Xiao et al.
Background and objective: Ulcerative colitis (UC) is a recognised precursor to colorectal cancer (CRC), yet the underlying relationship to genetic predisposition remains unclear. This study aimed to assess the genetic sus...
Pan-cancer analysis of HOMER1 in hepatocellular carcinoma revealing diagnostic potential and immune landscape with experimental validation [0.03%]
泛癌分析肝细胞癌中的HOMER1揭示其诊断潜力和免疫图谱并进行实验验证
Guohong Yan,Ziyan Lu,Jiakao Zhang et al.
Guohong Yan et al.
Objective: Homer scaffold protein 1 (HOMER1), a postsynaptic scaffold protein, regulates excitatory synapses and intracellular signaling and has been implicated in tumorigenesis. This study systematically evaluates the on...
The choice of adjuvant radiotherapy in adrenocortical carcinoma patients after radical adrenalectomy: a population-based analysis [0.03%]
肾上腺癌根治术后辅助放疗的选择：基于人群的分析
Minjuan He,Minqin He
Minjuan He
Purpose: This study aimed to more accurately screen the adrenocortical carcinoma(ACC) patients who would benefit from adjuvant radiotherapy after radical adrenalectomy. ...
Syeda Maham,Mudassir Khan,Aleeha Noor et al.
Syeda Maham et al.
Background: Myeloid and lymphoid progenitor cells can develop leukemia. Acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) are two types of myeloid leukemia, depending on how the disease progresses. Acute pro...
Epithelial guardians against cancer: integrating cell competition and extrusion in early tumor control [0.03%]
上皮细胞的癌症守护者：整合细胞竞争和挤出以期尽早控制肿瘤
Grecia Riofrio-Chung,César Rivera
Grecia Riofrio-Chung
Epithelial tissues maintain homeostasis by employing sophisticated mechanisms to promote clearance of precancerous cells, thus preventing tumorigenesis. Two key processes-cell competition and extrusion-collectively termed epithelial defense...
SMAD4 mutation drives gut microbiome shifts toward tumor progression in colorectal cancer [0.03%]
SMAD4突变驱动结直肠癌肠道微生物组向肿瘤进展方向转移
Travis J Gates,Dechen Wangmo,Kyra M Boorsma Bergerud et al.
Travis J Gates et al.
Background: Colorectal cancer (CRC) progression is driven by a series of sequential mutations in key driver genes; however, the factors underlying tumor progression and metastasis remain poorly understood. Mutations in TP...
LncRNA LINC02381/miR-133b axis promotes tumorigenesis and predicts survival in pancreatic cancer [0.03%]
长链非编码 RNA LINC02381/miR-133b 轴通过促进胰腺癌的发生发展用于预后评估
Junna He,Ronglin Bai,Xuehu Song et al.
Junna He et al.
Background: LncRNA LINC02381 has emerged as a promising tumor biomarker; however, its involvement in the pathogenesis of pancreatic cancer remains unexplored at this time. The objective of this study is to elucidate the r...
A meta-analysis based on propensity analysis studies comparing neoadjuvant immunochemotherapy and neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma [0.03%]
倾向性分析的meta分析：对比新辅助免疫化疗和新辅助放化疗治疗食管鳞癌患者的有效性和安全性
Zixian Jin,Jiani Zhu,Jian Zhang et al.
Zixian Jin et al.
Background: To systematically compare the efficacy and safety of neoadjuvant immunochemotherapy (NICT) and neoadjuvant chemoradiotherapy (NCRT) in the treatment of resectable esophageal squamous cell carcinoma (ESCC). ...
Database analysis reveals endophilin A expression as a marker of metastasis and prognosis in breast cancer [0.03%]
数据库分析揭示内philin A表达作为乳腺癌转移和预后的标志
Vikrant Mehta,Sohidul Islam,Harit Kasana et al.
Vikrant Mehta et al.
Background: Endophilin A, a family of Bin-Amphoterisin-Rvs (BAR) domain-conserved proteins, is found in several tissues and is associated with disease pathogenesis. In patients with breast cancer, endophilin A expression ...
Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis [0.03%]
探究白细胞端粒长度与肾细胞癌之间共享的遗传结构：跨性状分析
Li Wang,Jian-Wei Yang,Kang-Yu Wang et al.
Li Wang et al.