Toxicity and mechanistic analysis of di(2-ethylhexyl)phthalate in renal cell carcinoma progression: a systematic study with network toxicology and molecular docking strategies [0.03%]
网络毒理学和分子对接策略在Di(2-乙基己基)邻苯二甲酸促进肾细胞癌进展的毒性及机制研究中的系统应用
Biao Ran,Xinyi Wang,Bohan Liu et al.
Biao Ran et al.
Millions of tons of unrecycled plastic pollute landfills and oceans, and di(2-ethylhexyl) phthalate (DEHP), a plasticizer classified as a possible carcinogen, is found in many environments, and poses health risks. Renal cell carcinoma (RCC)...
Comprehensive investigation identifies CPSF3 as a novel prognostic and oncogenic biomarker in bladder cancer [0.03%]
全面调查将CPSF3鉴定为膀胱癌新型预后和致癌生物标志物
Zhiyang Ma,Yining Hao,Wei He et al.
Zhiyang Ma et al.
Background: Bladder cancer (BC) remains a prevalent malignancy worldwide, with rising incidence rates each year. Despite progress in therapeutic strategies, many patients suffer recurrence or progression, emphasizing the ...
Transcriptomic landscape of NK cell-related genes in hepatocellular carcinoma: associations with prognosis and therapeutic response [0.03%]
肝细胞癌中NK细胞相关基因的转录组谱系：与预后和治疗反应的关系
Yuxiang Wang,Wenqiang Liao,Jianbo Lin et al.
Yuxiang Wang et al.
Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous malignancy, in which natural killer (NK) cells play a crucial role in tumor progression and immune surveillance. This study aimed to characterize the transcriptomic lan...
Development and validation of a leukemia prognostic model through single-cell RNA sequencing and machine learning approaches [0.03%]
通过单细胞RNA测序和机器学习方法开发并验证白血病预后模型
Doujia Chen,Jie Yang,Mengting Wang et al.
Doujia Chen et al.
Background: Leukemia prognosis varies significantly among patients, highlighting the need for accurate prediction tools. Emerging evidence suggests that the immune microenvironment plays a crucial role in leukemia progres...
Impact of immune cells on renal cancer risk: a Mendelian randomization analysis with clinical cohort validation [0.03%]
基于临床队列验证的免疫细胞对肾癌发病风险的影响：孟德尔随机化分析
Shunqi Chen,Xiangkun Li,Chunyu Wu et al.
Shunqi Chen et al.
Background: The causal relationship between immune cells and renal cancer risk remains unclear, as observational studies are susceptible to confounding factors.To evaluate the causal relationship between immune cells and ...
Expression and prognosis of CXCL13 in uterine corpus endometrial carcinoma based on bioinformatics analysis [0.03%]
基于生物信息学分析的子宫体子宫内膜癌中CXCL13的表达及预后价值
Zhu Wang,Yongning Gao
Zhu Wang
Objective: The biological significance of the chemokine ligand C-X-C motif chemokine ligand 13 (CXCL13) may play a significant role in the pathogenesis of uterine corpus endometrial carcinoma (UCEC). This study aims to id...
Mendelian randomization analysis reveals protective effects of LIFR and CXCL5 against breast cancer risk [0.03%]
孟德尔随机化分析揭示LIFR和CXCL5可降低乳腺癌风险
Yuchuan Liu
Yuchuan Liu
Background: The causal connection between circulating inflammatory biomarkers and breast cancer susceptibility has not been definitively established. Meth...
The value of circulating methylated septin 9 in the diagnosis and prognostic assessment of gastric cancer [0.03%]
血清Septin 9基因甲基化检测在胃癌诊断和预后评估中的价值
Jingru Ni,Xiaohe Hao,Yongkang Wu et al.
Jingru Ni et al.
Background: Gastric cancer (GC) is a lethal malignancy usually diagnosed at advanced stages due to limited detection methods. Invasive examinations, such as electronic gastroscopy and pathological biopsy, have limitations...
Pan-cancer and machine learning reveal the role of cell adhesion molecules in prognosis, immune remodeling, and anti-tumour therapy in lower-grade gliomas [0.03%]
泛癌症和机器学习揭示细胞粘附分子在低级别胶质瘤预后、免疫重塑和抗肿瘤治疗中的作用
Xu Zheng,Jianpeng Liu,Jiheng Zhang
Xu Zheng
Cell adhesion molecules (CAMs) have emerged as pivotal regulators of tumor biology, influencing invasion, metastasis, and the tumor microenvironment (TME) through their roles in cell-cell and cell-matrix interactions. Despite their critical...
Single-cell profiling of ERBB family receptors identifies ERBB3 as a key regulator in head and neck squamous cell carcinoma progression [0.03%]
单细胞ERBB家族受体谱系鉴定出ERBB3是头颈鳞癌进展中的关键调节因子
Yuling Luo,Youwei Li,Shuqin Liu et al.
Yuling Luo et al.
The ERBB receptor family is widely implicated in epithelial malignancies, yet the functional and immunological significance of ERBB3 in head and neck squamous cell carcinoma (HNSCC) remains insufficiently characterized. In this study, we em...