LINC01123: a pan-cancer "molecular commander" deciphering the CeRNA network atlas for precision diagnosis and therapy [0.03%]
LINC01123：一种泛癌症“分子指挥官”，用于解析精准诊断和治疗的 ceRNA 网络图谱
Zheng Chen,Weijian Zhu,Qiang Yi et al.
Zheng Chen et al.
LINC01123, a long non-coding RNA (lncRNA) encoded on chromosome 2q13, is a crucial regulator in various human cancers. It spans 8,302 nucleotides and is implicated in malignancies like lung, ovarian, colorectal, head and neck, oral, cervica...
Comprehensive analysis of immune escape-related prognostic signature in high-grade glioma [0.03%]
高_grade_胶质瘤中与免疫逃逸相关的预后标志物的全面分析
Chongkang Ren,Jinyi Cai,Yanhua Liu et al.
Chongkang Ren et al.
Objective: High-grade glioma (HGG) is one of the most lethal malignancies. Immune escape is considered to be a reason for the failure of immunotherapy for HGG patients, and there is currently no immune escape-related prog...
Predictive role of a novel nutrition and inflammation-based model in the short-term clinical outcomes and health-related quality of life of patients undergoing radical gastrectomy: a retrospective cohort study [0.03%]
新型营养和炎症模型在根治性胃切除术患者短期临床结局及生活质量中的预测作用：回顾性队列研究
Pengfei Li,Chunhua Zhou
Pengfei Li
Objective: To explore the predictive value of nutritional and inflammatory indicators in the short-term clinical outcomes and health-related quality of life (HRQoL) of patients undergoing radical gastrectomy. ...
Léa-Isabelle Renaud,Elisabeth St-Laurent,Coralie Compare et al.
Léa-Isabelle Renaud et al.
Endometrial cancer (EC) is the most prevalent gynecological malignancy in developed countries, with incidence rates steadily increasing due to factors such as obesity, aging populations, and changes in reproductive behavior. While mortality...
Identifying the causal role and therapeutic potential of immune-related genes in bladder cancer: a Mendelian randomization study [0.03%]
基于梅涅尔随机化研究的膀胱癌免疫相关基因致病性评价及药物研发潜力评估研究
Yonggang Chen,Qingfeng Yu,Xiaomei Jiang et al.
Yonggang Chen et al.
Background: Bladder cancer, a highly aggressive malignancy, necessitates effective therapeutic strategies due to the significant correlation between muscle invasion and prognosis. Despite advancements in immunotherapy, th...
Oncogenic EME1 promotes tumor progression and immune modulation in human cancers with therapeutic targeting potential [0.03%]
致癌基因EME1促进人类癌症的肿瘤进展和免疫调节并具有治疗靶向潜力
Muhammad Alaa Eldeen,Abdelrahman Mostafa,Farag Mamdouh et al.
Muhammad Alaa Eldeen et al.
Background: EME1, a critical DNA repair endonuclease, has emerged as a potential oncogene implicated in genome instability and cancer progression. However, its pan-cancer roles, prognostic significance, immune interaction...
PH responsive hydrogel nanocomposites for targeted Shikonin delivery enhance anti PDL1 immunotherapy in osteosarcoma [0.03%]
用于靶向姜黄宁递送的pH响应性水凝胶纳米复合材料可增强骨肉瘤中抗PDL1免疫治疗
Xiang-Yi Chen,Xian-Qin Yang,Ming-Yang Wang
Xiang-Yi Chen
Objective: To enhance the therapeutic effect of atezolizumab on osteosarcoma (OS) by constructing a pH-responsive hydrogel nanocomplex (Gel@PLGA@FA) as a delivery platform for Shikonin. ...
An exploratory study on the potential of angiogenic genes in early HNSCC detection [0.03%]
血管生成基因在头颈鳞癌早期诊断中的应用价值研究探索性研究
Mao-Ling Huang,Fa-Zhang Lan,Lei Xu et al.
Mao-Ling Huang et al.
Background: The early diagnosis and prognosis of head and neck tumors are crucial for enhancing patients’ quality of life. This study focuses on angiogenic genes to develop prognostic and diagnostic models, offering a no...
B cell-associated research in non-small cell lung cancer: a bibliometric analysis of current landscapes and future directions [0.03%]
非小细胞肺癌中B细胞相关研究的文献计量分析：现状与未来方向研究
Yuxin Zhang,Xiuyu Chen,Wanzi Mai et al.
Yuxin Zhang et al.
Background: Recent years have witnessed growing interest in the interplay between B cells and non-small cell lung cancer (NSCLC) amid deepening investigations into cancer immunotherapy. B cells play pivotal roles in immun...
Glutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels [0.03%]
谷酰基辅酶A脱氢酶(GCDH)通过调节谷酰基肉毒碱水平增强肾癌风险
Xuanshuo Liu,Bohua Chen,Jianghao Yuan et al.
Xuanshuo Liu et al.
Background: Crotonylation, a recently identified lysine acylation, plays a critical role in post-translational modifications [1]. It has been implicated in tumorigenesis by modulating metabolic reprogramming [2], DNA repa...