Genetic and clinical insights into the coexistence of multiple myeloma and diffuse large B cell lymphoma from a case report and systematic review with bioinformatics analysis [0.03%]
遗传和临床对多发性骨髓瘤和弥漫性大B细胞淋巴瘤共存的见解：病例报告及生物信息学分析的系统评价
Alireza Zangooie,Moein Piroozkhah,Zahra Ghasemi et al.
Alireza Zangooie et al.
Background: Multiple myeloma (MM) and diffuse large B-cell lymphoma (DLBCL) are B-cell malignancies that rarely coexist in a single patient, presenting significant diagnostic and therapeutic challenges. While MM primarily...
Baseline vitamin D levels and progression-free survival in patients with HR+/HER2-metastatic breast cancer treated with ribociclib: a retrospective single-center analysis [0.03%]
既往病史接受过维生素D治疗的HR阳性/HER2阴性转移性乳腺癌患者在使用瑞博西尼进行治疗后的无进展生存期：一项单中心回顾性分析
Selahattin Çelik,Bengü Dursun,Serkan Gülcü et al.
Selahattin Çelik et al.
Background: Vitamin D has been implicated in cancer biology and immunity, yet its prognostic relevance in patients receiving CDK4/6 inhibitors remains unclear. ...
Deubiquitinating enzymes-mediated post-translational modifications of ferroptosis regulates cancer drug resistance [0.03%]
去泛素化酶介导的铁死亡后翻译修饰调控癌症耐药性研究进展
Lili Zhang,Ming Li,Yumin Wang et al.
Lili Zhang et al.
Cancer drug resistance remains a formidable challenge in oncology, severely limiting the efficacy of conventional chemotherapy, targeted therapy, and immunotherapy. Ferroptosis, an iron-dependent form of regulated cell death characterized b...
Bibliometric analysis and knowledge mapping of thoracic SMARCA4-deficient undifferentiated tumor [0.03%]
胸腔SMARCA4缺陷型未分化肿瘤的 bibliometric 分析和知识图谱研究
Yujun Lin,Di Wu,Lujing Jiang et al.
Yujun Lin et al.
Background: Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a rare and highly aggressive malignancy with poor prognosis and no established standard therapy. This study aimed to map the research landscape...
Synergistic efficacy of radiotherapy and immunotherapy enhances clinical outcomes in patients with advanced non-small cell lung cancer [0.03%]
放射治疗与免疫治疗的协同效应可增强晚期非小细胞肺癌患者的临床疗效
Jiafeng Liang,Lucheng Zhu,Kan Wu et al.
Jiafeng Liang et al.
Background: Immunotherapy has become a primary treatment for advanced non-small cell lung cancer (NSCLC), although drug resistance is inevitable. Radiotherapy enhances immunotherapy efficacy, particularly in early to mid-...
Transcription factors remodel tumor immune microenvironment by impacting multiple immune cells [0.03%]
转录因子通过影响多种免疫细胞重塑肿瘤免疫微环境
Bei Xue,Chengwu He,Ye Tian
Bei Xue
Transcription factors (TFs) are key drivers of tumorigenesis because of their crucial role in regulating aberrant gene expression. They contribute to tumor cell proliferation, invasion, and migration and play a pivotal role in enabling tumo...
Multifactorial diagnostic model combining SAT-PCA3 in prostate cancer [0.03%]
结合SAT-PCA3的前列腺癌多因素诊断模型
Zeyu Luo,Shengjie Dai,Jing Jin et al.
Zeyu Luo et al.
Purpose: To investigate the feasibility of Simultaneous Amplification and Testing PCA3 (SAT-PCA3, a urine-based prostate cancer-specific biomarker) combined with conventional clinical information in the diagnosis of prost...
Metabolic pathway signatures define prognostic subtypes of lung adenocarcinoma [0.03%]
代谢途径特征定义肺腺癌预后亚型
Doris Kafita,Zitha Mukwamba,Vanity Mapulanga et al.
Doris Kafita et al.
Metabolic reprogramming is a core hallmark of cancer, yet how it contributes to the clinical heterogeneity of lung adenocarcinoma (LUAD) remains poorly understood. Here, by applying unsupervised clustering to the metabolic transcriptomes of...
Identification of a novel human gut microbes and microbial metabolites related genes signature for prognostic implication in head and neck squamous carcinomas [0.03%]
用于头颈部鳞状细胞癌预后判断的新型人类肠道微生态及代谢产物相关基因标志物识别研究
Xuan Yang,Sai Liang,Piao Wang et al.
Xuan Yang et al.
Background: The gut microbiota acts as a critical driver influencing the pathogenesis, therapeutic response, and clinical outcomes across various cancer types. This study aimed to investigate the prognostic value of human...
Cormac J Jennings,Stefan J Marciniak,Giulia Pinton et al.
Cormac J Jennings et al.
Aim: To investigate the expression of succinate dehydrogenase B and its potential as a therapeutic target in pleural mesothelioma (PM). Methods: ...