Multi-omics and spatial transcriptomics identify KCMF1 as an immune-metabolic driver of hepatocellular carcinoma progression [0.03%]
多组学和空间转录组学鉴定出KCMF1是肝细胞癌进展的免疫代谢驱动因素
Zhan Liu,Saobo Wu,Yinshi Li et al.
Zhan Liu et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, characterized by poor prognosis and limited treatment options. Ubiquitination, a key post-translational modification, plays crucial roles in cancer progression. However,...
Correlating obstructive sleep apnea and lung adenocarcinoma using hub gene signatures and molecular mechanisms [0.03%]
利用枢纽基因特征及分子机制关联阻塞性睡眠呼吸暂停与肺腺癌
Li Zhang,Lei Yang,Gang Chen et al.
Li Zhang et al.
Background: Obstructive sleep apnea (OSA) affects nearly 1 billion adults worldwide, and it is relatively common in patients with lung adenocarcinoma (LUAD). This study aimed to identify potential shared transcriptomic si...
Pan-cancer investigation identifies ARL4A as a prospective therapeutic indicator for thyroid cancer [0.03%]
泛癌症研究鉴定到ARL4A是甲状腺癌的潜在治疗标志物
Yingli Men,Jizhi Zhao,Ruiting Feng et al.
Yingli Men et al.
Background: ADP-ribosylation factor-like 4 A (ARL4A), a small GTPase involved in cytoskeletal dynamics and signal transduction, exhibits dysregulated expression in various cancers, yet its comprehensive role across tumor ...
Regulation of autophagy by the p53 family and the implications for cancer therapies [0.03%]
P53家族对自噬的调控及其在癌症治疗中的意义
I-Lun Hsin,Chia-Chi Chen,Yu-Te Sung et al.
I-Lun Hsin et al.
The p53 family, including p53, p63, and p73, play pivotal roles in various biological functions and are vitally relevant to cancer biology. Autophagy is an evolutionarily conserved catabolic process and stress-response mechanism that is act...
The promising role of cathepsins as biomarkers and therapeutic targets in glioblastoma [0.03%]
猫hepsin作为胶质母细胞瘤生物标志物和治疗靶点的潜在作用
Elsa Calcaterra,Davide Labellarte,Ahmed Hasan et al.
Elsa Calcaterra et al.
Glioblastoma (GB) is the most aggressive and lethal primary brain tumor in adults, characterized by extensive intratumoral heterogeneity, high invasiveness, and resistance to standard therapies. Despite advances in surgical techniques and c...
Curcumin as a neuroprotective agent against platinum-induced peripheral neuropathy: a double-blind randomized clinical trial [0.03%]
姜黄素作为防治铂类药物外周神经毒性的神经保护剂：一项双盲随机对照临床试验
Mohsen Zabihi,Farahnaz Hoseinzadeh,Mahla Mostafaei et al.
Mohsen Zabihi et al.
Background: Chemotherapy-induced peripheral neuropathy (CIPN) particularly from platinum-based agents remains a major dose-limiting complication, impairing patients' quality of life. This double-blind randomized clinical ...
Plasma interleukin-8 as a predictive biomarker for tyrosine kinase inhibitor response in advanced hepatocellular carcinoma [0.03%]
细胞因子白介素-8作为预测肝细胞癌酪氨酸激酶抑制剂反应标志物的研究
Sujin Kim,Hye Ri Ahn,Hui Gyeong Kim et al.
Sujin Kim et al.
Background and aim: Hepatocellular carcinoma (HCC) is the predominant primary liver cancer and third leading cause of cancer-related death. Despite improvements in overall survival (OS), those in HCC-specific survival rat...
Identification of ribosomal stress related signature genes and immune microenvironment analysis in ovarian cancer based on multi-machine learning [0.03%]
基于多机器学习的卵巢癌核糖体应激相关标志基因鉴定及免疫微环境分析
Xuechuan Han,Yan Yu,Yang Fan et al.
Xuechuan Han et al.
Background: Ovarian cancer (OC) is a highly aggressive malignancy with poor prognosis and limited response to immunotherapy. Ribosomal stress, a cellular response to disrupted ribosome biogenesis, has been increasingly im...
Exploring the efficacy of XAV939 and LF3 in targeting β-catenin signalling in gallbladder cancer cell lines [0.03%]
探索XAV939和LF3在靶向胆囊癌细胞系中β-catenin信号传导中的有效性
Akanksha Kashyap,Sheikh Mohammad Umar,Arundhathi J R Dev et al.
Akanksha Kashyap et al.
Purpose: Gallbladder cancer (GBC) is a common biliary malignancy in India, with poor prognosis and disappointing outcomes despite radical surgery, including high recurrence rates and low 5-year survival. This underscores ...
Characterization of telomere-related gene subtypes in lung adenocarcinoma and their implications for prognosis and treatment [0.03%]
肺癌腺癌端粒相关基因亚型的特征及其对预后和治疗的意义
Jingyi Gao,Yuansheng Zhao,Zhiying Cheng et al.
Jingyi Gao et al.
Background: Telomeres, located at chromosome ends, regulate cell division and maintain genomic stability. Telomere-related genes (TRGs) play essential roles in tumorigenesis and immune escape, but their mechanisms in lung...