Causal plasma metabolites for breast cancer risk: a two-sample Mendelian randomization study with colocalization evidence [0.03%]
乳腺癌风险的因果血浆代谢物：带有共定位证据的两样本孟德尔随机化研究
Hanghang Chen,Yueyuan Xu,Zepeng Wang et al.
Hanghang Chen et al.
Background: Breast cancer pathogenesis involves complex metabolic dysregulation, yet causal biomarkers remain elusive. This study aimed to assess causal effects of 1,400 human plasma metabolites on breast cancer (BC) risk...
COVID-19, inflammatory cytokines, and digestive system cancers: a bidirectional Mendelian study and mediation analysis [0.03%]
关于新冠肺炎、炎症细胞因子和消化系统癌症的双向孟德尔随机化研究及中介分析
Yi Liang,Wei Xiao,Bo Deng et al.
Yi Liang et al.
Background: Gastrointestinal cancers pose a significant global health burden, contributing to 8% of cancer cases and a substantial number of deaths each year. Meanwhile, the Corona Virus Disease 2019(COVID-19) pandemic ha...
Molecular mechanisms of RACK1-driven metastasis in pancreatic ductal adenocarcinoma revealed by single-cell RNA sequencing [0.03%]
单细胞RNA测序揭示胰腺导管腺癌中RACK1驱动转移的分子机制
Hangyu Liu,Tingxin Wang,Yuying Cui et al.
Hangyu Liu et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with significant cellular heterogeneity, which poses a significant challenge for treatment. We integrated three single-cell RNA sequencing (scRNA-seq) datasets to con...
Mendelian randomization reveals contrasting effects of immune signaling molecules on bone and articular cartilage malignancies [0.03%]
孟德尔随机化揭示免疫信号分子对骨和关节软骨恶性肿瘤的影响相反
Haiying Huang,Yanshan Lin,Ming Xiang et al.
Haiying Huang et al.
Background: The complex relationship between immune signaling molecules and cancer development remains incompletely understood. This study aimed to investigate potential causal relationships between specific immune factor...
Identification of anoikis-related tumor microenvironment characteristics and prognostic signature in ovarian cancer at bulk and single-cell levels [0.03%]
基于卵巢癌大规模和单细胞水平的肿瘤微环境特征识别及其预后标志物研究
Zhenye Tang,Chenfei Zhou,Yinyin Xu et al.
Zhenye Tang et al.
Background: Ovarian cancer (OC) remains among the deadliest cancers in women worldwide. Anoikis, a critical process that prevents the establishment of detached cells in non-native sites, is closely associated with cancer ...
The expression of miR-381-3p in acute myeloid leukemia and its effect on corresponding cell proliferation and apoptosis [0.03%]
急性髓系白血病中miR-381-3p的表达及其对相应细胞增殖和凋亡的影响
Jiali Hu,Peixin Zhang,Hongxia Zhang
Jiali Hu
Background: To investigate the expression, clinical significance, progression, and prognosis of miR-381-3p in acute myeloid leukemia (AML), as well as its impact on AML cell proliferation and apoptosis, in order to provid...
Immune cell dynamics and prognostic role of M2 macrophages and LDOC1 in colon adenocarcinoma [0.03%]
结肠腺癌免疫细胞动态及M2型巨噬细胞和LDOC1预后标志物的作用研究
Laibin Luo,Zhimin Xu,Hongwu Lin et al.
Laibin Luo et al.
Background: Colon adenocarcinoma (COAD) is influenced by the tumor microenvironment, including immune cell dynamics, particularly M2 macrophages. Understanding these dynamics can offer insights into tumor progression and ...
Integrated single-cell and Mendelian randomization analyses: dissecting underlying causes of varied efficacy in immune neoadjuvant therapy for esophageal carcinoma [0.03%]
整合单细胞和孟德尔随机化分析：解剖免疫新辅助治疗食管癌疗效差异的潜在原因
Jiaxin Li,Sibo Meng,Ying Zhou et al.
Jiaxin Li et al.
Background: Esophageal cancer has a low 5-year survival rate despite treatments. scRNA-seq and MR offer insights into neoadjuvant treatment efficacy for precision medicine. ...
Correction: Smoking and alcohol specific alterations in miRNA expression in head and neck squamous cell carcinoma [0.03%]
纠正：吸烟和酒精引起的头颈部鳞状细胞癌中miRNA表达的特异性改变
Mohd Younis Bhat,Vishalakshi Nanjappa,Mariana Brait et al.
Mohd Younis Bhat et al.
Published Erratum
Discover oncology. 2025 Oct 16;16(1):1903. DOI:10.1007/s12672-025-03828-x 2025
Integrated bioinformatics analysis of common molecular mechanisms and biomarkers in oral squamous cell carcinoma and periodontal disease [0.03%]
口腔鳞状细胞癌和牙周病的共通分子机制与生物标志物的整合生物信息学分析
Lin Wu,Peng She,Chenguang Qiu et al.
Lin Wu et al.
Background: Oral Squamous Cell Carcinoma (OSCC) and Periodontal Disease (PD) are two distinct yet interconnected conditions with complex molecular mechanisms. This study aimed to analyze transcriptomic data from both dise...