COL22A1 expression identifies aggressive glioma and independently predicts survival through integrated multiomics and clinical validation [0.03%]
COL22A1表达识别胶质瘤的侵袭性并通过整合多组学和临床验证独立预测预后
Wei-Wen Hsu,Wen-Shin Song,Pei-Chi Chang et al.
Wei-Wen Hsu et al.
Background: Gliomas, especially IDH‑wildtype astrocytomas, remain lethal despite multimodal therapy. Collagen type XXII alpha-1 (COL22A1) exhibits oncogenic activity in other cancers but remains underexplored in brain tu...
TAM family kinases are potential candidate targets for therapeutic intervention in chronic myeloid leukemia [0.03%]
泰米家族激酶是慢性髓性白血病治疗的潜在靶点候选者
Maryam Yousaf,Khadija Arif,Dilawar Khan
Maryam Yousaf
Background: Chronic Myeloid Leukemia (CML) is a hematologic disorder depicted by BCR::ABL1 translocation; a constitutively active tyrosine kinase (TK) and a hallmark of CML. Kinase domain mutations and the activation of a...
Potential causal association and mechanistic insights of chronic HBV infection in extrahepatic cancer progression [0.03%]
慢性HBV感染与额外肝脏癌症发展的潜在因果关系及机制见解
Zhihui Wei,Weiqiang Wu
Zhihui Wei
Background: Chronic hepatitis B virus (HBV) infection is a major global health concern, contributing to both hepatic and extrahepatic complications, including cancer. While its association with liver cancer is well establ...
Unveiling the global research status and intellectual map of cancer and immunosuppressants [0.03%]
揭示癌症与免疫抑制剂的全球研究现状及智力图谱
Tianyi Yuan,Yamin Zhao,Yunna Ma et al.
Tianyi Yuan et al.
Background: The use of immune checkpoint inhibitors (ICIs) has significantly advanced cancer therapy, improving survival rates and prognosis for many patients. This study employs bibliometric methods to explore the curren...
From cold to hot tumors: feasibility of applying therapeutic insights to TNBC [0.03%]
从冷肿瘤到热肿瘤：TNBC治疗思路的可行性研究
Shaozhang Yan,Xinyue Sun,Kuanyu Wang
Shaozhang Yan
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is characterized by the absence of estrogen receptors (ERs), progesterone receptors (PRs), and human epidermal growth factor receptor 2 (HER2). Due to its i...
Identification and validation of prognostic genes for lung adenocarcinoma prognosis based on PANoptosis-related genes [0.03%]
基于PANoptosis相关基因的肺腺癌预后基因的识别与验证
Guo-Qiang Song,Yu-Ying Wu,Tian-Li He et al.
Guo-Qiang Song et al.
Background: PANoptosis, a newly identified form of cell death, has been linked to both the destruction of cancer cells and the regulation of antitumor immunity. This study aimed to establish a PANoptosis-related signature...
Xiaoyue Deng,Zhiqiong Yu,Weihua Hu
Xiaoyue Deng
The FAT atypical cadherin (FAT) gene family comprises FAT atypical cadherin 1 (FAT1), 2 (FAT2), 3 (FAT3), and 4 (FAT4). These transmembrane adhesion proteins are essential for regulating cell polarity, adhesion, and migration, and are invol...
High VCP/p97 expression associates with low PD-L1 TPS in oropharyngeal squamous cell carcinoma [0.03%]
高VCP/p97表达与口咽鳞癌低PD-L1肿瘤比例相关性分析
Inga Marte Charlott Seuthe,Markus Ruwe,Franz Mitze et al.
Inga Marte Charlott Seuthe et al.
Comprehensive analysis of KLHL35 expression and its prognostic value in cancer: implications for colorectal cancer diagnosis and therapy [0.03%]
KLHL35在癌症中的表达及预后价值的全面分析：结直肠癌诊断和治疗的启示
Rong Qin,Yiyao Duan,Shasha Bao et al.
Rong Qin et al.
Thymoquinone-conjugated liposomes improve cytotoxic and proapoptotic effects against hepatocellular cancer by altering the EGFR/ERK/MEK signaling axis [0.03%]
姜黄素衍生物小豆蔻明共轭脂质体通过改变EGFR/ERK/MEK信号轴提高对肝细胞癌的细胞毒性和促凋亡效应
Shaymaa A Abdulmalek,Fatma A Mahmoud,Doaa Awad et al.
Shaymaa A Abdulmalek et al.
Modulating the signaling axis between tumors and their environment is one of the key strategies to slow down the progression of hepatocellular carcinoma (HCC). In this study, we aimed to design a polyethylene glycolated liposome loaded with...