Study on the in vitro and in vivo killing effects of PD-1 antibody-secreting c-Met-targeted CAR-T cells on esophageal cancer cell line ECA109 [0.03%]
携带PD-1抗体的c-Met靶向CAR-T细胞体内外杀伤食管癌ECA109细胞系的效应研究
Shang Peng,Yanqiu Li,Yanjun Zhang et al.
Shang Peng et al.
Background: This study was designed to investigate the in vitro and in vivo killing effects of PD-1 antibody-secreting c-Met-targeted CAR-T cells on esophageal cancer cell line ECA109. ...
EGFR gene amplification in IDH-wildtype glioblastomas: an integrative bioinformatic and histopathological analysis using immunohistochemistry and fluorescence in situ hybridization [0.03%]
整合基因组和组织病理学分析IDH野生型胶质母细胞瘤中EGFR扩增的状况：免疫组织化学与荧光原位杂交的联合应用
Anass Oukhdouch,Basma Zinbi,Souad Sellami et al.
Anass Oukhdouch et al.
Background: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, characterized by marked histopathological features such as high proliferative activity, mitoses, necrosis, and microvascular ...
D-mannose suppresses HIF-1α mediated metabolic reprogramming in clear cell renal cell carcinoma [0.03%]
D-mannose抑制透明细胞肾细胞癌中的HIF-1α介导的代谢重编程
Ziyin Tian,Ruonan Zhang,Yan Ma et al.
Ziyin Tian et al.
The inactivation mutation of VHL drives the progression of clear cell renal cell carcinoma (ccRCC), while the deletion of VHL leads to the failure of HIF-1/2α to degrade normally through the ubiquitin proteasome pathway. Notably, the abnor...
Expressions, immune associations, and prognostic values of mitochondrial ribosomal protein MRPL3 in the pan cancer landscape [0.03%]
泛癌分析中线粒体核糖体蛋白MRPL3的表达、免疫关联及预后价值
Jing Lin,Wenzhe Chen,Yaodong Zhao et al.
Jing Lin et al.
Background: MRPL3, a member of the mitochondrial ribosomal family, is involved in the translation of mitochondria-related proteins. However, its role in tumors remains unclear. ...
Pan-cancer analysis of role of LOXL4 and experiment validation in osteosarcoma [0.03%]
LOXL4的泛癌分析及其在骨肉瘤中作用的实验验证
Wenjie Chen,Fujie Xie,Jie Lv et al.
Wenjie Chen et al.
Background: Osteosarcoma is an aggressive bone malignancy with high metastatic potential and poor prognosis, primarily affecting children and adolescents. Although lysyl oxidase-like 4 (LOXL4) has been implicated in tumor...
Identification of promising lung cancer targets from human plasma proteins via Mendelian randomization [0.03%]
基于孟德尔随机化的血浆蛋白质组数据用于肺癌药物靶点的识别
Xiao-Dong Shao,Zhou-Lin Miao,Wei-Jie Yu
Xiao-Dong Shao
Background: Lung cancer (LC) is the most prevalent form of malignant neoplasm globally, as well as the major cause of cancer-related death. Identifying effective pharmaceutical targets is paramount in advancing the develo...
Emerging photothermal agents combined with immunotherapy for cancer treatment [0.03%]
新兴的光热剂与免疫疗法结合用于癌症治疗
Tian Xu,Xueping Yang,Xinyu Chen et al.
Tian Xu et al.
Background: Immunophotothermal therapy (IPTT), combining immune checkpoint inhibitors and photothermal therapy, represents a promising synergistic anticancer strategy that enhances tumour-specific immunity alongside local...
Ferroptosis in AML: nanoparticles, biomarkers, and immune rewiring for therapeutic breakthroughs [0.03%]
AML中铁死亡的研究：纳米颗粒、生物标志物和免疫重编程在治疗中的突破性应用
Farzaneh Tavakoli,Mohammad Ali Araskhan,Fatemeh Karimpour et al.
Farzaneh Tavakoli et al.
Acute myeloid leukemia (AML) remains a formidable clinical challenge due to high relapse rates and therapeutic resistance. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, glutathione depletion, and ...
Identification and characterization of lLF2 as a prognostic biomarker in HER2-positive breast cancer using Mendelian randomization and machine learning [0.03%]
利用孟德尔随机化和机器学习鉴定并表征lLF2作为HER2阳性乳腺癌预后生物标志物的能力
Xiyun Quan,Yi Deng,Meiyuan Huang et al.
Xiyun Quan et al.
Background: HER2-positive breast cancer is an aggressive molecular subtype characterized by high recurrence rates and poor prognosis. Identifying robust biomarkers for prognosis and therapeutic response is essential to im...
The oncogenic role of miR-155 on oral cancer progression and treatment strategies [0.03%]
miR-155在口腔癌发生发展中的致癌作用及其治疗策略研究
Alexandra Iulia Aghiorghiesei,Nikolay Mehterov,Andreea Nutu et al.
Alexandra Iulia Aghiorghiesei et al.
Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive malignancy within head and neck cancers, often associated with risk factors such as tobacco use, alcohol consumption, and HPV infection. MicroRNAs (miRNAs), small non-coding ...