Causal roles of cathepsins family members in breast cancer subtypes: insights from Mendelian randomization and bioinformatics analysis [0.03%]
乳腺癌亚型中丝氨酸蛋白酶家族成员的因果作用：来自孟德尔随机化和生物信息学分析的见解
Lin Tan,Junlian Xiang,Yi Lu et al.
Lin Tan et al.
Purpose: This study aims to explore the causal association between members of the cathepsin family and breast cancer subtypes, with a focus on their expression profiles, prognostic significance, and potential molecular me...
Peripheral SNCA+ cells as a poor prognostic factor for nivolumab therapy in advanced gastric cancer [0.03%]
外周SNCA阳性细胞作为晚期胃癌尼沃单抗治疗不良预后的因素
Chie Kudo-Saito,Hiroshi Imazeki,Kengo Nagashima et al.
Chie Kudo-Saito et al.
Background: We previously demonstrated that immune cells expressing α-synuclein (SNCA) are dramatically increased in peripheral blood of patients with gastric cancer (GC), but rarely in healthy donors, and that blocking ...
Current strategies and novel immunotherapeutic approaches for overcoming immune resistance in glioblastoma [0.03%]
胶质母细胞瘤克服免疫抵抗的当前策略和新型免疫治疗手段
Mehrdad Nourizadeh,Saeid Mohammadzadeh Mounesyar,Mahdi Salimi Movahhed et al.
Mehrdad Nourizadeh et al.
CER1 as a manganese ion metabolism gene drives gastric cancer progression and therapeutic potential via oxidative stress and tumor microenvironment regulation [0.03%]
CER1作为锰离子代谢基因通过氧化应激和肿瘤微环境调控驱动胃癌进展及治疗潜力研究
Juan Hu,Ruian Zhu,Qiushi Huang et al.
Juan Hu et al.
Background: Metal ions are vital for biological regulation and contribute to gastric cancer (GC) development, but the mechanisms are unclear. This study investigates the role of the manganese ion metabolism (MIM)-related ...
Prognostic significance of GPR132 in papillary thyroid carcinoma: insights from integrated machine learning and its role in regulating TPC-1 cell growth [0.03%]
GPR132在乳头状甲状腺癌中的预后意义：综合机器学习的洞察及其在调节TPC-1细胞生长中的作用
Jinghua Gao,Zihan Cai,Shoupeng Ding et al.
Jinghua Gao et al.
Object: This study utilizes machine learning and bioinformatics methods to analyze data identifying GPR132 as a reliable potential prognostic gene for papillary thyroid carcinoma (PTC).The experiments elucidated potential...
Comprehensive pan-cancer evaluation of NUP85 prognosis, immune infiltration response, and validation in prostate cancer [0.03%]
泛癌分析NUP85的预后、免疫浸润反应及其在前列腺癌中的验证
Zhijun Chen,Han Guan,Long Chen et al.
Zhijun Chen et al.
Background: Although NUP85 is a member of the nuclear pore complex (NPC) and is associated with chromosome variation and tumor regulation, its specific role in cancer development remains unclear and requires further resea...
Macrophage-mediated delivery of ganciclovir nanocomplexes inhibits the pathogenicity of Kaposi's sarcoma-associated herpesvirus [0.03%]
巨噬细胞介导的gan-ciclovir纳米复合物递送可抑制卡波西肉瘤相关疱疹病毒的致病性
Haopeng Tan,Lixia Yao,Runa Zhang et al.
Haopeng Tan et al.
Kaposi's sarcoma-associated herpesvirus (KSHV), a member of the γ-herpesvirus family, is associated with the development of various malignancies. Ganciclovir (GCV) is a competitive inhibitor of DNA and can inhibit the synthesis of KSHV vir...
Association of antipsychotic drug target genes and risk of lung cancer: a Mendelian randomization study [0.03%]
精神分裂症药物靶点基因与肺癌风险的孟德尔随机化研究
Jun Xiang,Guangming Xiang,Ming Zhan et al.
Jun Xiang et al.
Background: Antipsychotic drugs are associated with various tumors, but their causal relationship with lung cancer risk remains unclear. We aimed to investigate this association using Mendelian randomization (MR) analyses...
Third-generation versus first-generation EGFR tyrosine kinase inhibitors in Asian patients with advanced EGFR mutant non-small cell lung cancer: a meta-analysis of randomized controlled trials [0.03%]
第三代和第一代表皮生长因子受体酪氨酸激酶抑制剂治疗亚洲晚期表皮生长因子受体突变型非小细胞肺癌患者的疗效：随机对照试验的meta分析
Manzhen Xu,Wei Ding,Linlin Wan et al.
Manzhen Xu et al.
Background: Third-generation EGFR-TKIs (TGETs) have demonstrated improved clinical outcomes compared to first-generation EGFR-TKIs (FGETs) in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). Nonetheless, the ...
Left-sided clear cell renal cell carcinoma initially presenting with isolated abdominal wall metastasis: a case report [0.03%]
左侧肾透明细胞癌伴孤立性腹壁转移的病例报告
Ji Yu,ZhongRu Sun,Qingyu Chen et al.
Ji Yu et al.
Isolated abdominal wall metastasis of clear cell renal cell carcinoma is exceedingly rare. We report a case where isolated abdominal wall metastasis served as the initial manifestation while the primary renal carcinoma remained occult. The ...