Microenvironmental regulation and remodeling of breast cancer angiogenesis: from basic mechanisms to clinical therapeutic implications [0.03%]
乳腺癌血管生成的微环境调控与重塑：从基本机制到临床治疗意义
Ziling Zhou,Hanyi Zhong,Han Wang et al.
Ziling Zhou et al.
Angiogenesis, the formation of new blood vessels, is a pivotal process in breast cancer (BC) progression and metastasis, intricately regulated by complex interactions within the tumor microenvironment (TME). While the vascular endothelial g...
Deciphering the causal relationships between plasma metabolites, peripheral cells, inflammatory factors and DLBCL for discovering novel therapeutic targets [0.03%]
揭示血浆代谢物、外周细胞、炎性因子与DLBCL间的因果关系以发现新的治疗靶点
Ming Xu,Li Xu,Wenhua Zhu et al.
Ming Xu et al.
Background: Diffuse large B-cell lymphoma (DLBCL) is defined as a highly heterogeneous type of lymphoma which lacks specific biomarkers and drug targets. Past studies revealed changes in plasma metabolites, immune cells a...
Comprehensive analysis of mitochondria-associated genes in glioblastoma via single-cell and bulk RNA sequencing [0.03%]
通过单细胞和批量RNA测序全面分析胶质母细胞瘤中的线粒体相关基因
Fangyuan Wang,Ao Huo,Minghe Li et al.
Fangyuan Wang et al.
Glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options and poor survival. Mitochondrial dysfunction and metabolic reprogramming, particularly the Warburg effect, are increasingly recognized as critical drivers ...
GNPNAT1 acts as a prognostic biomarker associated with immune infiltration in lung adenocarcinoma and promotes the proliferation and invasion of cancer cells [0.03%]
GNPNAT1在肺癌免疫浸润中的预后标志物作用及其促进癌细胞增殖侵袭的作用机制研究
Qingfeng Li,Qingyin Lan,Hongmiao Wang et al.
Qingfeng Li et al.
Background: Lung cancer persists as the foremost cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) representing the predominant histological subtype. Although GNPNAT1 has been implicated as a pr...
Clinical value of the novel inflammatory-nutritional marker PALR in predicting early postoperative recurrence of colorectal cancer [0.03%]
新型炎症-营养标志物PALR在预测结直肠癌术后早期复发中的临床价值
Shiwei Xu,Durong Liao,Chunzai Feng et al.
Shiwei Xu et al.
Background: The purpose of this study is to evaluate the clinical application value of (platelet × albumin)/lymphocyte ratio (PALR) as a novel prognostic indicator in predicting early postoperative recurrence in colorect...
Integrated WGCNA retrieval of T-cell exhaustion genes related to radiosensitivity in locally advanced cervical cancer and prediction of immunotherapy efficacy [0.03%]
整合WGCNA检索局部晚期宫颈癌与放射敏感性相关的T细胞耗竭基因及预测免疫治疗疗效
Meilian Dong,Chunyan Zhang,Xiangxian Zhang et al.
Meilian Dong et al.
For more than two decades, concurrent chemoradiotherapy (CCRT) has been considered the standard treatment for locally advanced cervical cancer (LACC) and has achieved remarkable clinical results. Nevertheless, 30-40% of treated patients wou...
The potential of luteolin-conjugated mesoporous silica nanoparticles functionalized with folic acid in targeted cancer therapy in an in vitro model [0.03%]
叶绿醇-共轭介孔二氧化硅纳米颗粒的潜在作用功能化叶酸靶向癌症疗法在内的体外模型中
Maryam Hosseini,Masoud Homayouni Tabrizi,Bita Behboodian et al.
Maryam Hosseini et al.
This study reports a novel targeted cancer therapy platform based on luteolin-loaded mesoporous silica nanoparticles functionalized with folic acid (Lu-MSN-FA NPs). MSNs were synthesized via a CTAB-templated sol-gel process employing tetrae...
RAD51-AS1 inhibits the migration and invasion of prostate cancer cells by up-regulating RARA to activate ZYX transcription [0.03%]
RAD51-AS1通过上调RARA激活ZYX转录来抑制前列腺癌细胞的迁移和侵袭
Zhijun Chen,Xinwei Wang,Likai Mao et al.
Zhijun Chen et al.
Background: Prostate cancer (PCa) is one of the most prevailing cancers threatening men health around the world. Mounting studies have revealed that dysregulated long non-coding RNAs (lncRNAs) might contribute to cancer d...
Prognostic and immunological characterization of elderly acute myeloid leukemia evaluated by butyrate metabolism-related genes [0.03%]
丁酸盐代谢相关基因评估的老年急性髓系白血病的预后和免疫学特征分析
Yiwei Li,Liming Shan
Yiwei Li
Background: The diagnostic and therapeutic value of butyrate metabolism-related genes (BMRGs) in cancer has been widely applied, however, their prognosis and potential therapeutic value in elderly acute myeloid leukemia (...
Mendelian randomization and single-cell analysis reveal novel genetic risk factors and cellular heterogeneity in glioblastoma [0.03%]
孟德尔随机化和单细胞分析揭示了胶质母细胞瘤中的新型遗传风险因素及细胞异质性
Jun Li,Jing Xu,Lianshu Ding et al.
Jun Li et al.
Background: Glioblastoma is the most aggressive primary brain tumor with limited therapeutic options and poor prognosis. Understanding the genetic determinants and cellular complexity of glioblastoma is crucial for develo...