Integrative analysis of single-cell and transcriptome RNA sequencing to establish a NAT10-related signature for prognostic prediction of uveal melanoma [0.03%]
整合单细胞和转录组RNA测序进行综合分析，建立用于预测脉络膜黑色素瘤预后的NAT10相关标志物
Wancheng Liu,Ying Xu
Wancheng Liu
Uveal melanoma (UVM), an intraocular malignant tumor originating from uveal melanocytes, not only induces blindness but also exhibits a high fatality risk. Despite the emergence of numerous local treatment modalities for UM in recent years,...
Mediation Mendelian randomization study of plasma proteomics reveals the causal relationship and potential mechanisms between iron and colorectal adenocarcinoma [0.03%]
基于蛋白质组学的中介孟德尔随机化研究揭示了铁与结肠腺癌的因果关系及潜在机制
Xin Chen,Shaojie Fu,Fan Li et al.
Xin Chen et al.
Colorectal adenocarcinoma (CRA) is the third most frequently detected cancer worldwide. The relationship between iron and CRA is ambiguous and interactive, especially when considering the heterogenesis of colon and rectal adenocarcinoma. Th...
LRP11 as a potential predictor of poor prognosis and immune suppression in lung adenocarcinoma [0.03%]
LRP11作为肺腺癌不良预后和免疫抑制的潜在预测因子
Runlin Feng,Yanping Tao,Huimin Liu et al.
Runlin Feng et al.
Background: Lung adenocarcinoma (LUAD), the predominant histologic subtype of non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related mortality worldwide. However, stable biomarkers that simultaneous...
A rare case of primary transverse colon adenocarcinoma penetrating the abdominal wall [0.03%]
罕见的原发性横结肠腺癌穿透腹壁病例报告
Boren Tan,Lei Liu,Huiming Wu et al.
Boren Tan et al.
Colorectal cancer (CRC) is the third most prevalent malignancy globally and the second leading cause of cancer mortality as of 2020. Its clinical presentation varies by stage, progressing from asymptomatic early disease to advanced symptoms...
CCL20 mediates the effect of cathepsin S on hepatocellular carcinoma development insights from Mendelian randomization and bioinformatics analysis [0.03%]
猫弹性蛋白酶S通过CCL20介导肝癌发生的研究：基于孟德尔随机化和生物信息学分析的见解
Chunling Yuan,Qian Li,Min Luo et al.
Chunling Yuan et al.
Background: Dysregulation of cathepsins is associated with cancer development and progression. However, their specific role in hepatocellular carcinoma (HCC) remains unclear. ...
Neoadjuvant immunochemotherapy versus chemotherapy alone for locally advanced esophageal squamous cell carcinoma: a real-world retrospective study [0.03%]
新辅助免疫化疗与单纯化疗治疗局部晚期食管鳞癌的疗效比较：一项真实世界回顾性研究
Lin Zhou,Yaochen Huang,Yan Qian et al.
Lin Zhou et al.
Background: Esophageal squamous cell carcinoma (ESCC) remains a significant global health burden. Neoadjuvant therapy followed by surgery is the standard treatment for locally advanced ESCC, yet optimal strategies to enha...
Factors associated with taxane-associated acute pain syndrome in pancreatic cancer patients receiving gemcitabine and nab-paclitaxel [0.03%]
与接受吉西他滨和白蛋白结合型紫杉醇治疗的胰腺癌患者相关急性疼痛综合征的因素
Yoshitaka Saito,Yoh Takekuma,Yoshito Komatsu et al.
Yoshitaka Saito et al.
Purpose: Taxane-associated acute pain syndrome (T-APS) is a common adverse event in patients treated with gemcitabine (GEM) + nanoparticle albumin-bound paclitaxel (nab-PTX) for pancreatic cancer. As several T-APS risk fa...
The correlation of DPM1 overexpression with immune infiltration and poor prognosis in hepatocellular carcinoma [0.03%]
DPM1过表达与肝细胞癌免疫浸润及不良预后的相关性研究
Laiwei You,Yang Zhou,Yong Cheng et al.
Laiwei You et al.
Background: The DPM1 gene, crucial for glycosylation processes, has shown abnormal expression in various cancers, raising interest in its potential oncogenic role and as a biomarker in hepatocellular carcinoma (HCC). ...
Advances in polycythemia vera treatment with targeted therapies and clinical trials [0.03%]
靶向疗法和临床试验在多毛细胞白血病治疗中的进展
Doaa Hassanien,Rashid A AlYafei,Omar H Metwally et al.
Doaa Hassanien et al.
Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by excessive red blood cell production, leading to a heightened risk of thrombosis, hemorrhage, and progression to myelofibrosis. While traditional therapies such...
Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma [0.03%]
整合转录组和免疫信息学分析确定tpx2、bub1b和ube2c作为子宫内膜癌的诊断生物标志物和治疗靶点
Shuyang Zhou,Jirui Sun,Jinmei Li et al.
Shuyang Zhou et al.
Objective: This study aimed to identify novel diagnostic and prognostic biomarkers in endometrial carcinoma (EC) using integrative bioinformatics and immunohistochemical validation, with a focus on potential therapeutic t...