Antimicrobial peptides for anticancer and antiviral therapy: last promising update [0.03%]
用于抗癌和抗病毒治疗的抗菌肽：最新展望
Aisa Bahar,Mahyar Porbaran,Meisam Khazaei et al.
Aisa Bahar et al.
Antimicrobial peptides (AMPs) are short sequences of amino acids, typically 6-50 residues long, that serve as a natural defense mechanism against viruses, cancer, and other pathogens. They function primarily by disrupting microbial membrane...
Prognostic model for pediatric brain tumors based on tumor microenvironment-specific gene signatures [0.03%]
基于肿瘤微环境特异性基因特征的儿童脑肿瘤预后模型
Yuxin Liu,Longgang Sang,Alexandr N Chernov et al.
Yuxin Liu et al.
Background: Pediatric brain tumors (PBT) represent a major public health challenge, accounting for approximately 15-20% of all childhood malignancies. The tumor microenvironment (TME) plays a crucial role in tumor progres...
CENP-F promotes HCC cell proliferation mediated by super enhancer reader BRD4 [0.03%]
CENP-F通过超级增强子阅读蛋白BRD4促进肝癌细胞增殖
Yunhui Liu,Wenjiao Chen,Yuxin Niu et al.
Yunhui Liu et al.
Centromere protein F (CENP-F) is highly expressed in hepatocellular carcinoma (HCC), but the specific mechanism by which it regulates the occurrence and development of HCC is currently unclear. The activities of the super enhancer (SE) read...
Comprehensive analysis of a machine learning prognostic model for the interaction between mitochondrial function and lactylation in lung adenocarcinoma [0.03%]
全面分析肺腺癌线粒体功能与乳酰化相互作用的机器学习预测模型
Yaozong Xia,Zhongxun Li,Xiu Cao et al.
Yaozong Xia et al.
Background: Mitochondrial function and lactylation play important roles in the development of lung adenocarcinoma (LUAD). However, the impact of their interaction on the prognosis of LUAD still needs further investigation...
A rare case of cellular angiofibroma with sarcomatous transformation occurred in the popliteal fossa [0.03%]
腘窝发生血管纤维瘤细胞型罕见伴肉瘤样变病例报告
Lina Zhao,Zhenyu Liu,Feng Guan et al.
Lina Zhao et al.
Background: Cellular angiofibroma (CAF) represents a rare, benign mesenchymal neoplasm. Histologically, it is characterized by a spindle-cell component closely resembling spindle-cell lipoma and an abundance of thick-wall...
Characterization of PANoptosis-based markers for ischemic stroke and their appealing implications in improving prognosis and in glioma patients [0.03%]
基于PANoptosis的缺血性脑卒中标志物的特征分析及其在改善预后和胶质瘤患者中的潜在意义
Jianli Zhang,Caiwen Liu,Weimin Zhong et al.
Jianli Zhang et al.
Objective: Pyroptosis, apoptosis and necroptosis separately participate in the pathogenesis of ischemic stroke, but the implication of PANoptosis in this disease is still unexplored. This study conducted a comprehensive i...
The immune infiltration and prognostic significance of complement and coagulation cascade-related genes in lung adenocarcinoma [0.03%]
补体和凝血级联反应相关基因在肺腺癌中的免疫浸润及预后意义分析
Chunhui Li,Zongqian Yuan,Chengrui Fu et al.
Chunhui Li et al.
Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer. Previous studies have highlighted the critical roles of complement and coagulation cascades in tumor development, maintenance, and therapeutic response. However, the o...
ADAM9 drives PD-L1 shedding via IL-6 suppression and exploring therapeutic role of Bufalin treatment in hepatocellular carcinoma [0.03%]
ADAM9通过抑制IL-6驱动PD-L1脱落及Bufalin在肝癌治疗中的作用研究
Mandana AmeliMojarad,Melika AmeliMojarad,Alireza Pourmahdian
Mandana AmeliMojarad
The treatment landscape for advanced hepatocellular carcinoma (HCC) has changed significantly with the recent introduction of immunotherapy, particularly immune checkpoint inhibitors (ICIs), such as those for programmed cell death ligand 1 ...
Integrative multi-omics and preclinical analyses identify miR-4776-5p as a prognostic radiosensitizer for patients undergoing radiotherapy for head-and-neck cancer [0.03%]
整合多组学和临床前分析识别出miR-4776-5p作为头颈部癌症放疗患者的预后放射增敏剂
Yo-Liang Lai,Chun-Chieh Wang,Kai-Wen Hsu et al.
Yo-Liang Lai et al.
Radiotherapy remains a cornerstone treatment for head-and-neck cancer (HNC), yet resistance to radiation therapy significantly limits clinical outcomes. MicroRNAs (miRNAs) have emerged as promising regulators of radiosensitivity; however, t...
Unveiling the role of protein palmitoylation in gastric cancer diagnosis via machine learning [0.03%]
基于机器学习的蛋白质棕榈酰化在胃癌诊断中的作用研究
Zhong Hua Shen,Jingyu Wu
Zhong Hua Shen
Gastric cancer (GC) is a highly morbid and mortal gastrointestinal malignancy, urgently requiring sensitive and specific biomarkers for detection. Protein palmitoylation, a reversible lipid modification process, has been connected to tumor ...