Integrated analysis of single-cell and bulk RNA sequencing identifies GSTM4 as a tumor suppressor and prognostic biomarker in breast cancer [0.03%]
单细胞和批量RNA测序的综合分析确定GSTM4是乳腺癌中的抑癌基因和预后生物标志物
Zhen Yu,Weikang Yun,Qian Zhang et al.
Zhen Yu et al.
Background: Breast cancer (BC) continues to be a predominant cause of cancer-related deaths among women globally, highlighting the complexity of the disease, its propensity for metastasis, and resistance to conventional t...
Multidimensional analysis of hsa-miR-140-3p and CKS1B correlation via the MAPK/ERK pathway in lung adenocarcinoma progression [0.03%]
基于MAPK/ERK通路的hsa-miR-140-3p和CKS1B相关性在肺腺癌进展中的多维度分析
Kexin Luo,Meihan Liu,Yaoshu Song et al.
Kexin Luo et al.
Cyclin-Dependent Kinase Subunit 1B (CKS1B) is significantly upregulated in lung adenocarcinoma (LUAD) tissues and is associated with poor clinical outcomes, such as shorter overall survival (OS) and progression-free survival (PFS). High CKS...
Xin-Li Feng,Gang Su,Qi Jia et al.
Xin-Li Feng et al.
Glioma is one of the most malignant tumors in the brain, with high tumor heterogeneity. Traditional treatment methods, such as surgery, radiotherapy and chemotherapy, face numerous challenges and still pose serious threats to human health. ...
Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer [0.03%]
泛癌分析和实验验证胃癌中ADAM12的意义
KanKan Yang,Rui Chen,Bing Jiang
KanKan Yang
Background: ADAM12, a member of the disintegrin and metalloproteinase family, has been involved in multiple cancers, yet its precise role in pan-cancer progression still remains elusive. ...
The causal association between psychiatric disorders and gynecological cancer: a bidirectional Mendelian randomization study [0.03%]
精神病障碍和妇科癌之间的因果关系：双向孟德尔随机化研究
Yaru Wang,Lin Qi,Yitong Li et al.
Yaru Wang et al.
Background: Previous studies have suggested a positive causal relationship between schizophrenia and ovarian, breast, and lung cancers. Additionally, research has indicated a positive correlation between bipolar disorder ...
Harnessing the power of exosomes in leukemia: from molecular messengers to clinical applications [0.03%]
外泌体在白血病中的作用：从分子信使到临床应用
Mohammad Amin Ansarian,Mahsa Fatahichegeni,Yuqi Wang et al.
Mohammad Amin Ansarian et al.
Exosomes, nanosized extracellular vesicles (30-150 nm), have emerged as pivotal mediators in leukemia pathogenesis, fundamentally altering our understanding of the disease and therapeutic approaches. These membrane-bound carriers transport ...
Effect of fibrinogen like protein 1 on cisplatin-resistance in laryngeal carcinoma through targeting integrinβ1 in vivo and in vitro [0.03%]
靶向整合素β1蛋白的血纤维蛋白原同源物1在体内外通过影响顺铂耐药性抑制喉癌细胞活性的作用研究
Zhen Li,Jianlin Fang,Hongzhou Ge et al.
Zhen Li et al.
Objective: To explore the relationship between fibrinogen like protein 1 (FGL1) and cisplatin (CDDP) resistance in laryngeal carcinoma, as well as dissect the underlying molecular regulatory pathways. ...
PEITC restores chemosensitivity in cisplatin-resistant non-small cell lung cancer by targeting c-Myc/miR-424-5p [0.03%]
PEITC通过靶向c-Myc/miR-424-5p恢复顺铂耐药非小细胞肺癌的化学敏感性
Hao Ding,Yan Deng,Rong Zeng et al.
Hao Ding et al.
We aimed to investigate the potential of phenethyl isothiocyanate (PEITC) as an effective therapeutic agent in overcoming cisplatin resistance in non-small cell lung cancer (NSCLC). Cell viability was measured using the CCK-8 assay and flow...
TRIM21 as a potential prognostic biomarker and therapeutic target affects the growth of pancreatic cancer [0.03%]
TRIM21作为胰腺癌预后生物标志物和治疗靶点影响胰腺癌生长
Dingfa Sun,Shijun Zheng,Siyi Wang et al.
Dingfa Sun et al.
Background: Pancreatic cancer is called “the king of cancer” because of its high degree of malignancy, poor prognosis, and lack of effective treatment. It encompasses multiple subtypes, with pancreatic adenocarcinoma (P...
S-adenosylmethionine enhances anti-PD-1 efficacy in uveal melanoma by targeting EZH2 [0.03%]
腺苷蛋氨酸通过靶向EZH2增强抗PD-1在脉络膜黑色素瘤中的疗效
Guo-Jun Gao,Jin Yuan,Jin-Jin Huang et al.
Guo-Jun Gao et al.
Objective: To investigate the effect of S-adenosylmethionine (SAM) on enhancing anti-programmed death 1 (PD-1) therapy in uveal melanoma (UM) by targeting Enhancer of Zeste homolog 2 (EZH2). The synergistic effect of SAM ...