Causal links and immune mediators between blood cells and breast cancer risk: a mendelian randomization study [0.03%]
基于血液细胞和乳腺癌风险间的因果关系和免疫介导研究的孟德尔随机化研究
Meizi Song,Yu Liu,Jiaxu Dong et al.
Meizi Song et al.
Background: Previous studies have indicated a potential association between blood cells and breast cancer risk, but the causal relationships involving specific blood cell metrics and the role of immune cell mediators rema...
Changing patterns of colorectal cancer in China between 2000 and 2016 based on tertiary hospital data [0.03%]
基于三级医院数据的中国2000至2016年结直肠癌发病趋势变化
Junling Wu,Hanwen Zhang,Zhe Luan et al.
Junling Wu et al.
Background: Colorectal cancer ranks fourth globally in cancer-related deaths, causing about nine million annual fatalities. Developed countries show higher mortality rates due to factors like aging, diet, obesity, inactiv...
Systems biology-driven identification of biomarkers and significant pathways in radiation-induced hormone-sensitive cancers [0.03%]
系统生物学驱动的辐射诱导的激素敏感性癌症生物标志物和重要途径识别
Suvitha Anbarasu,Sathyanarayan Balaji,Sudha Ramaiah et al.
Suvitha Anbarasu et al.
Radiation-induced damage to nucleic acid and other important cellular constituents could likely cause cancer. The present study has analyzed mutated genes with dysregulated expression signatures due to radiation. We have predicted biomarker...
Cuproptosis scoring system identifies novel molecular subtypes and modulates biological behavior in breast cancer [0.03%]
杯状体细胞坏死评分系统识别乳腺癌新分子亚型并调节其生物学行为
Rongyang Zou,Qiong Wu,Wanjun Zhao
Rongyang Zou
Background: Cuproptosis, a regulated mechanism of cell death mediated by copper, significantly influences tumor progression, prognosis, and antitumor immunity. Although cuproptosis-related genes (CRGs) exhibit therapeutic...
Integrated summary data-based Mendelian randomization and colocalization analysis reveals TNNT3 as a target of Deer-Antler-Ginseng-formula for triple-negative breast cancer [0.03%]
整合型总结数据的孟德尔随机化和共定位分析发现TNNT3是花鹿茸参配方治疗三阴性乳腺癌的作用靶点
Jianling Jia,Yuan Ma,Di Wu et al.
Jianling Jia et al.
Background: As an aggressive tumor type with poor prognosis, high recurrence and metastasis tendency, and lack of effective therapeutic targets, triple-negative breast cancer (TNBC) not only poses a remarkable treatment c...
FAM3B overexpression correlates with poor prognosis and immune dysregulation in colorectal cancer: insights from bioinformatics and Mendelian randomization analyses [0.03%]
FAM3B过表达与结直肠癌的不良预后和免疫失调相关：来源于生物信息学和孟德尔随机化分析的新见解
Peng Huang,Pei Li,Chengshuo Zhang et al.
Peng Huang et al.
Background: Colorectal cancer (CRC) ranks third in global cancer diagnoses and is the second leading cause of cancer-related deaths. Identifying novel therapeutic targets and effective prognostic markers is crucial to imp...
Bladder metastasis arising from right: sided invasive lobular carcinoma in bilateral synchronous discordant primary breast cancers-a rare case [0.03%]
右侧浸润性小叶癌继发双侧同步异时 primaries乳腺原发肿瘤膀胱转移一例罕见病例报告
Ting Wen,Shiying Liu,Xiaomei Li et al.
Ting Wen et al.
Bladder metastasis of breast cancer is clinically rare, and there is no report on simultaneous bilateral breast cancer with different pathological types complicated by bladder metastasis. This study reports a case of bladder metastasis in a...
Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning [0.03%]
通过多组学和深度学习阐明SIRT2在肝细胞癌中的作用
Changan Chen,Tingmei Yang,Caiyuan Yu et al.
Changan Chen et al.
Background: Hepatocellular carcinoma (HCC) is a prevalent global malignancy characterized by a high incidence and poor prognosis. Current diagnostic and therapeutic modalities are insufficient to meet the demands for effe...
Non-coding RNAs-mediated regulation of the MAPK pathway in gastric cancer: translational perspectives [0.03%]
胃癌中非编码RNA介导的MAPK通路调节：转化前景
Darmadi Darmadi,Komeil Aghazadeh-Habashi,Sona Ayvazyan et al.
Darmadi Darmadi et al.
In recent years, non-coding RNAs (ncRNAs) have been acknowledged as master regulators of various cellular behaviors, and their dysregulation contributes to the development, progression, and therapeutic resistance of various cancers, includi...
Development and validation of a nomogram for predicting postoperative survival in patients with multifocal hepatocellular carcinoma [0.03%]
多发病灶肝细胞癌患者术后生存预测 nomogram的制订和验证
Bojun Liu,Gongming Zhang,Guangming Li
Bojun Liu
Background: Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor and the third leading cause of cancer-related death worldwide. Despite the significance of multifocality in HCC (M-HCC), most studies hav...